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Albert J. Jin, Ph.D. Staff Scientist Instrumentation Research and Development Laboratory of Bioengineering and Physical Science Bldg. 13, Rm. 3N 18D Tel: 301-435-4612 Fax: 301-496-6608 E-mail: jina@mail.nih.gov

Research Expertise and Interests

Dr. Albert Jin's current research focuses in the areas of macromolecular biophysics, biomedical imaging, nanobiotechnology, and nanomedicine. Most recently, his research activities included studies on biological and lipid membranes, malaria vaccine characterization, subcellular trafficking dynamics and mechanisms, muscle proteins and G-protein coupled receptors (GPCR), nanoparticles, polymers, and biomaterials. Dr. Jin's primary research tools are atomic force microscopy (AFM) and optical and fluorescent spectroscopic imaging, and in an effort to optimize data interpretation and outcomes, he consistently seeks to improve strategies for complex data analysis and biomedical modeling methods.

Dr. Jin has over 15 years of interdisciplinary biomedical research experience, and his work often involves collaborative research with fellow scientists and clinicians across the NIH campus. He received his Bachelor's degree in physics from Nanjing University in China in 1985, an M.Sc. degree in experimental physics from Penn State University in 1988, and a Ph.D. degree in theoretical physics from the University of Maryland at College Park in 1992. He is a member of the Biophysical Society, the American Society for Cell Biology, the American Physical Society, and the BIO IT Coalition.

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Selected Publications

Jin AJ, Prasad K, Smith PD, Lafer EM and Nossal RJ: Measuring the elasticity of clathrin coated vesicles via atomic force microscopy. Biophys J, 90 , 3333-44, 2006.

Forbes J, Jin AJ, Ma K, Gutierrez-Cruz G, Tsai W and Wang K: Titan PEVK segment: Charge-driven elasticity of the open and flexible polyampholyte. J Muscle Res Cell Motil, 27, 2006.

Choi EJ , Jin AJ, Niu S-L, Smith PD and Litman BJ: Visualizing individual rhodopsin (a G-protein coupled receptor) molecules in native disk and reconstructed membranes via atomic force microscopy. Tech. Proc. 2004 Nanotech. & Trade Show, 1, 63-66, 2004.

Tokumasu F, Jin AJ, Feigenson GW and Dvorak JA: Nanoscopic lipid domain dynamics revealed by atomic force microscopy. Biophys J, 84, 2609-2618, 2003.

Sinz A, Jin AJ and Zschornig O: Evaluation of the metal binding properties of a histidine-rich fusogenic peptide by electrospray ionization fourier transform ion cyclotron resonance mass spectroscopy. Journal of Mass Spectrometry, 38, 1150-1159, 2003.

Tokumasu F, Jin AJ and Dvorak JA: Lipid membrane phase behaviour elucidated in real time by controlled environment atomic force microscopy. J Electron Microsc, 51, 1-9, 2002.

Wang K, Forbes JG and Jin AJ: Single molecule measurements of titin elasticity. Prog Biophys Mol Biol, 77, 1-44, 2001.

Forbes JG, Jin AJ and Wang K: Atomic force microscope study of the effect of the immobilization substrate on the structure of force-extension curves of a multimeric protein. Langmuir, 17, 3067-3075, 2001.

Jin AJ and Nossal R: Rigidity of triskelion arms and clathrin nets. Biophys J, 78, 1183-1194, 2000.

Jin AJ, Huster D, Gawrisch K and Nossal R: Light scattering characterization of extruded lipid vesicles. Eur. Biophys. J. Biophys. Lett, 28, 187-199, 1999.

Jin AJ, Edidin M, Nossal R and Gershfeld NL: A singular state of membrane lipids at cell growth temperatures. Biochemistry, 38, 13275-13278, 1999.

Huster D, Jin AJ, Arnold K and Gawrisch K: Water permeability of polyunsaturated lipid membranes measured by 0-17 NMR. Biophys J, 73, 855-864, 1997.

Jin AJ and Nossal R: Topological mechanisms involved in the formation of clathrin-coated vesciles. Biophys J, 65, 1523-1537, 1993.

Fisher M E and Jin AJ: Is short-range "critical" wetting a first-order transition? Phys Rev Lett, 69, 792-795, 1992.

Jin AJ, Bjurstrom MR and Chan MH: Thermodynamic evidence of first-order melting of Xe on graphite. Phys Rev Lett, 62, 1372-1375, 1989.

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Patents