Peter W Schuck

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Peter Schuck portrait
Peter
Schuck
Ph.D.
Senior Investigator
Biography

Dr. Schuck obtained his Ph.D. from the Goethe-University Frankfurt am Main, Germany, where he worked on interactions of integral proteins of the erythrocyte membrane using analytical ultracentrifugation. He received his post-doctoral research training in physical biochemistry with Dr. Allen Minton at NIDDK, and joined the Bioengineering and Physical Science Program of NCRR as a Research Fellow in 1997, developing biophysical methods for the study of protein interactions. In 2014 he was appointed an Earl Stadtman Investigator in NIBIB and Chief, Laboratory of Dynamics of Macromolecular Assembly. In 2021, he was granted tenure at NIH.

Research Interests

The Laoratory of Dynamics of Macromolecular Assembly develops biophysical methods to study protein interactions and the assembly of multi-protein complexes. Hallmarks of multi-protein complexes are multi-valent interactions and cooperativity. In the molecular machinery of cellular processes these constitute ubiquitous mechanisms for the integration and transfer of information.  Therefore, our focus is on the development of approaches for multi-component systems where several different macromolecular components interact to allow association and dissociation of different co-existing complexes in different states.  We are interested in the characterization of the number of assembly states, and their size, shape, and the interaction energetics. Complementary to crystallographic techniques, such solution interaction studies can provide information on the assembly principles of structurally polymorph multi-protein complexes. 

Our group has been particularly active in the development of quantitative hydrodynamic methods using sedimentation velocity analytical ultracentrifugation in conjunction with mathematical modeling of reaction/diffusion/sedimentation processes. We have recently embarked on the development of novel fluorescence detection approaches, which allow unprecedented sensitivity and resolution. We are also pursuing other techniques, including optical biosensing, isothermal titration calorimetry and global multi-method modeling approaches. We are dedicated to the dissemination of methodology, and have implemented our computational analysis methods in widely used software.  

We are involved in several collaborative applications in various fields including immunological protein complexes, viral proteins, membrane receptor complexes, and eye lens crystallins.

 

Publications

Juul-Madsen KParbo PIsmail ROvesen PLSchmidt VMadsen LSThyrsted JGierl SBreum MLarsen AAndersen MNRomero-Ramos MHolm CKAndersen GRZhao HSchuck PNygaard JVSutherland DSEskildsen SFWillnow TEBrooks DJVorup-Jensen T
Nat Commun
2024 Feb 09

Nguyen AZhao HMyagmarsuren DSrinivasan SWu DChen JPiszczek GSchuck P
bioRxiv
2024 Mar 22

Zhou BFunaki YHoriuchi HMa YGRöpke GSchuck PTohsaki AYamada T
Nat Commun
2023 Dec 11

Zhao HSyed AMKhalid MMNguyen ACiling AWu DYau WMSrinivasan SEsposito DDoudna JAPiszczek GOtt MSchuck P
bioRxiv
2023 Nov 23






Zhao HWu DHassan SANguyen AChen JPiszczek GSchuck P
Sci Adv
2023 Apr 05

Rodríguez-Blázquez ACarabias AMorán-Vaquero Ade Cima SLuque-Ortega JRAlfonso CSchuck PManso JAMacedo-Ribeiro SGuerrero Cde Pereda JM
Cell Commun Signal
2023 Feb 03

Zhao HNguyen AWu DLi YHassan SAChen JShroff HPiszczek GSchuck P
PNAS Nexus
2022 May

Zhao HNguyen AWu DLi YHassan SAChen JShroff HPiszczek GSchuck P
bioRxiv
2022 Feb 09

Bou-Assaf GMBudyak ILBrenowitz MDay ESHayes DHill JMajumdar RRinghieri PSchuck PLin JC
J Pharm Sci
2022 Jul

Weissman JDSingh AKDevaiah BNSchuck PLaRue RCSinger DS
J Biol Chem
2021 Nov

Harkness RWToyama YRipstein ZAZhao HSever AIMLuan QBrady JPClark PLSchuck PKay LE
Proc Natl Acad Sci U S A
2021 Aug 10

Martin EWHarmon TSHopkins JBChakravarthy SIncicco JJSchuck PSoranno AMittag T
Nat Commun
2021 Jul 23

Juul-Madsen KTroldborg AWittenborn TRAxelsen MGZhao HKlausen LHLuecke SPaludan SRStengaard-Pedersen KDong MMøller HJThiel SJensen HSchuck PSutherland DSDegn SEVorup-Jensen T
Proc Natl Acad Sci U S A
2021 Jul 27


Zhao HWu DNguyen ALi YAdão RCValkov EPatterson GHPiszczek GSchuck P
iScience
2021 Jun 25

Velazquez-Campoy AClaro BAbian OHöring JBourlon LClaveria-Gimeno REnnifar EEngland PChaires JBWu DPiszczek GBrautigam CTso SCZhao HSchuck PKeller SBastos M
Eur Biophys J
2021 May


Parupudi AChaturvedi SKAdão RHarkness RWDragulin-Otto SKay LEEsfandiary RZhao HSchuck P
Sci Rep
2021 Mar 11

Zhao HWu DNguyen ALi YAdão RCValkov EPatterson GHPiszczek GSchuck P
bioRxiv
2021 Feb 09

Zhao HNguyen ATo SCSchuck P
Eur Biophys J
2021 May

Conicella AEHuang RRipstein ZANguyen AWang ELöhr TSchuck PVendruscolo MRubinstein JLKay LE
Proc Natl Acad Sci U S A
2020 Oct 20

Chaturvedi SKParupudi AJuul-Madsen KNguyen AVorup-Jensen TDragulin-Otto SZhao HEsfandiary RSchuck P
MAbs
2020

Zhao HLi WChu WBollard MAdão RSchuck P
Curr Protoc Protein Sci
2020 Sep


Yarawsky AEJohns SLSchuck PHerr AB
J Biol Chem
2020 Apr 03

Zhao HDatta SAKKim SHTo SCChaturvedi SKRein ASchuck P
J Biol Chem
2019 Nov 08

Juul-Madsen KZhao HVorup-Jensen TSchuck P
Anal Biochem
2019 Dec 01

Montecinos-Franjola FChaturvedi SKSchuck PSackett DL
J Biol Chem
2019 Jun 28

To SCBrautigam CAChaturvedi SKBollard MTKrynitsky JKakareka JWPohida TJZhao HSchuck P
Anal Chem
2019 May 07

Lira ALFerreira RSTorquato RJSOliva MLVSchuck PSousa AA
Nanoscale Adv
2019 Jan 01



Chaturvedi SKSagar VZhao HWistow GSchuck P
J Am Chem Soc
2019 Feb 20

Manna AZhao HWada JBalagopalan LTagad HDAppella ESchuck PSamelson LE
Proc Natl Acad Sci U S A
2018 Dec 18

Chen ZDiaz GPollicino TZhao HEngle RESchuck PShen CHZamboni FLong ZKabat JDe Battista DBock KWMoore INWollenberg KSoto CGovindarajan SKwong PDKleiner DEPurcell RHFarci P
Proc Natl Acad Sci U S A
2018 Nov 27

Ge JElferich JGoehring AZhao HSchuck PGouaux E
Elife
2018 Aug 02

LeBrun TSchuck PWei RYoon JSDong XMorgan NYFagan JZhao H
PLoS One
2018


Lira ALFerreira RSTorquato RJSZhao HOliva MLVHassan SASchuck PSousa AA
Nanoscale
2018 Feb 15

Zhao HLomash SChittori SGlasser CMayer MLSchuck P
Elife
2017 Oct 23



Natarajan KMcShan ACJiang JKumirov VKWang RZhao HSchuck PTilahun MEBoyd LFYing JBax AMargulies DHSgourakis NG
Nat Commun
2017 May 16


Zhao HBoyd LFSchuck P
Curr Protoc Protein Sci
2017 Apr 03

Desai AKrynitsky JPohida TJZhao HSchuck P
PLoS One
2016


Marzahn MRMarada SLee JNourse AKenrick SZhao HBen-Nissan GKolaitis RMPeters JLPounds SErrington WJPrivé GGTaylor JPSharon MSchuck POgden SKMittag T
EMBO J
2016 Jun 15



Sousa AAHassan SAKnittel LLBalbo AAronova MABrown PHSchuck PLeapman RD
Nanoscale
2016 Mar 28


Morozov GIZhao HMage MGBoyd LFJiang JDolan MAVenna RNorcross MAMcMurtrey CPHildebrand WSchuck PNatarajan KMargulies DH
Proc Natl Acad Sci U S A
2016 Feb 23

Ma JZhao HSandmaier JAlexander Liddle JSchuck P
Biophys J
2016 Jan 05

Le Roy AWang KSchaack BSchuck PBreyton CEbel C
Methods Enzymol
2015


Zhao HGhirlando RAlfonso CArisaka FAttali IBain DLBakhtina MMBecker DFBedwell GJBekdemir ABesong TMBirck CBrautigam CABrennerman WByron OBzowska AChaires JBChaton CTCölfen HConnaghan KDCrowley KACurth UDaviter TDean WLDíez AIEbel CEckert DMEisele LEEisenstein EEngland PEscalante CFagan JAFairman RFinn RMFischle Wde la Torre JGGor JGustafsson HHall DHarding SECifre JGHerr ABHowell EEIsaac RSJao SCJose DKim SJKokona BKornblatt JAKosek DKrayukhina EKrzizike DKusznir EAKwon HLarson ALaue TMLe Roy ALeech APLilie HLuger KLuque-Ortega JRMa JMay CAMaynard ELModrak-Wojcik AMok YFMücke NNagel-Steger LNarlikar GJNoda MNourse AObsil TPark CKPark JKPawelek PDPerdue EEPerkins SJPerugini MAPeterson CLPeverelli MGPiszczek GPrag GPrevelige PERaynal BDRezabkova LRichter KRingel AERosenberg RRowe AJRufer ACScott DJSeravalli JGSolovyova ASSong RStaunton DStoddard CStott KStrauss HMStreicher WWSumida JPSwygert SGSzczepanowski RHTessmer IToth RTTripathy AUchiyama SUebel SFUnzai SGruber AVvon Hippel PHWandrey CWang SHWeitzel SEWielgus-Kutrowska BWolberger CWolff MWright EWu YSWubben JMSchuck P
PLoS One
2015


Chaires JBHansen LDKeller SBrautigam CAZhao HSchuck P
Methods
2015 Apr



Zhao HMa JIngaramo MAndrade EMacDonald JRamsay GPiszczek GPatterson GHSchuck P
Anal Chem
2014 Sep 16

Ghirlando RZhao HBalbo APiszczek GCurth UBrautigam CASchuck P
Anal Biochem
2014 Aug 01



Zhao HBalbo AMetger HClary RGhirlando RSchuck P
Anal Biochem
2014 Apr 15

May NAWang QBalbo AKonrad SLBuchli RHildebrand WHSchuck PHudson AW
J Virol
2014 Mar

Zhao HChen YRezabkova LWu ZWistow GSchuck P
Protein Sci
2014 Jan




Gustchina ELi MGhirlando RSchuck PLouis JMPierson JRao PSubramaniam SGustchina AClore GMWlodawer A
PLoS One
2013


Coussens NPHayashi RBrown PHBalagopalan LBalbo AAkpan IHoutman JCBarr VASchuck PAppella ESamelson LE
Mol Cell Biol
2013 Nov

Zhao HBerger AJBrown PHKumar JBalbo AMay CACasillas ELaue TMPatterson GHMayer MLSchuck P
J Gen Physiol
2013 Jun

Ghirlando RBalbo APiszczek GBrown PHLewis MSBrautigam CASchuck PZhao H
Anal Biochem
2013 Sep 01




Canzio DLiao MNaber NPate ELarson AWu SMarina DBGarcia JFMadhani HDCooke RSchuck PCheng YNarlikar GJ
Nature
2013 Apr 18

Zhao HGhirlando RPiszczek GCurth UBrautigam CASchuck P
Anal Biochem
2013 Jun 01





Olugbile SVillard VBertholet SJafarshad AKulangara CRoussilhon CFrank GAgak GWFelger INebie IKonate KKajava AVSchuck PDruilhe PSpertini FCorradin G
Vaccine
2011 Sep 16


Zhao HBrown PHMagone MTSchuck P
J Mol Biol
2011 Aug 19


Zhao HBrown PHSchuck P
Biophys J
2011 May 04





Potty ASKourentzi KFang HSchuck PWillson RC
Int J Biol Macromol
2011 Apr 01



Chaudhry CPlested AJSchuck PMayer ML
Proc Natl Acad Sci U S A
2009 Jul 28


Kumar JSchuck PJin RMayer ML
Nat Struct Mol Biol
2009 Jun

Gondeau CCorradin GHeitz FLe Peuch CBalbo ASchuck PKajava AV
Mol Biochem Parasitol
2009 Jun

Chaudhry CWeston MCSchuck PRosenmund CMayer ML
EMBO J
2009 May 20

Jian XBrown PSchuck PGruschus JMBalbo AHinshaw JERandazzo PA
J Biol Chem
2009 Jan 16




Goncalvez APChien CHTubthong KGorshkova IRoll CDonau OSchuck PYoksan SWang SDPurcell RHLai CJ
J Virol
2008 Jul

Binger KJPham CLWilson LMBailey MFLawrence LJSchuck PHowlett GJ
J Mol Biol
2008 Feb 29


Gohon YDahmane TRuigrok RWSchuck PCharvolin DRappaport FTimmins PEngelman DMTribet CPopot JLEbel C
Biophys J
2008 May 01

Lengyel JSStott KMWu XBrooks BRBalbo ASchuck PPerham RNSubramaniam SMilne JL
Structure
2008 Jan

Balbo ABrown PHBraswell EHSchuck P
Curr Protoc Immunol
2007 Nov


Mans JNatarajan KBalbo ASchuck PEikel DHess SRobinson HSimic HJonjic STiemessen CTMargulies DH
J Biol Chem
2007 Nov 30

Chen ZEarl PAmerico JDamon ISmith SKYu FSebrell AEmerson SCohen GEisenberg RJGorshkova ISchuck PSatterfield WMoss BPurcell R
J Virol
2007 Sep


Boukari HSackett DLSchuck PNossal RJ
Biopolymers
2007

Fernández MMBhattacharya SDe Marzi MCBrown PHKerzic MSchuck PMariuzza RAMalchiodi EL
Proteins
2007 Jul 01



Schuck PBoyd LFAndersen PS
Curr Protoc Cell Biol
2004 May

Schuck Pvan den Ameele HJaanson PRyckmans VHawley C
CNS Drugs
2004

Gonzales NRPadlan EADe Pascalis RSchuck PSchlom JKashmiri SV
Mol Immunol
2004 Jul




Houtman JCHigashimoto YDimasi NCho SYamaguchi HBowden BRegan CMalchiodi ELMariuzza RSchuck PAppella ESamelson LE
Biochemistry
2004 Apr 13




Weston MCSchuck PGhosal ARosenmund CMayer ML
Nat Struct Mol Biol
2006 Dec

Houtman JCYamaguchi HBarda-Saad MBraiman ABowden BAppella ESchuck PSamelson LE
Nat Struct Mol Biol
2006 Sep



Garcia ADOtero JLebowitz JSchuck PMoss B
J Biol Chem
2006 Apr 28


Chen ZMoayeri MZhou YHLeppla SEmerson SSebrell AYu FSvitel JSchuck PSt Claire MPurcell R
J Infect Dis
2006 Mar 01

Chen ZEarl PAmerico JDamon ISmith SKZhou YHYu FSebrell AEmerson SCohen GEisenberg RJSvitel JSchuck PSatterfield WMoss BPurcell R
Proc Natl Acad Sci U S A
2006 Feb 07



Che MMBoja ESYoon HYGruschus JJaffe HStauffer SSchuck PFales HMRandazzo PA
Cell Signal
2005 Oct





Gaidamakov SAGorshkova IISchuck PSteinbach PJYamada HCrouch RJCerritelli SM
Nucleic Acids Res
2005


González JMVélez MJiménez MAlfonso CSchuck PMingorance JVicente MMinton APRivas G
Proc Natl Acad Sci U S A
2005 Feb 08

Gupta NArthos JKhazanie PSteenbeke TDCensoplano NMChung EACruz CCChaikin MADaucher MKottilil SMavilio DSchuck PSun PDRabin RLRadaev SVan Ryk DCicala CFauci AS
Virology
2005 Feb 20

Vorup-Jensen TCarman CVShimaoka MSchuck PSvitel JSpringer TA
Proc Natl Acad Sci U S A
2005 Feb 01

Balbo AMinor KHVelikovsky CAMariuzza RAPeterson CBSchuck P
Proc Natl Acad Sci U S A
2005 Jan 04


Dam JGuan RNatarajan KDimasi NChlewicki LKKranz DMSchuck PMargulies DHMariuzza RA
Nat Immunol
2003 Dec


Ali SAIwabuchi NMatsui THirota KKidokoro SArai MKuwajima KSchuck PArisaka F
Biophys J
2003 Oct





Andersen JFFrancischetti IMValenzuela JGSchuck PRibeiro JM
J Biol Chem
2003 Feb 14





Schuck P
Lancet
2002 Jul 20



Andersen PSSchuck PSundberg EJGeisler CKarjalainen KMariuzza RA
Biochemistry
2002 Apr 23


Arthos JCicala CSteenbeke TDChun TWDela Cruz CHanback DBKhazanie PNam DSchuck PSelig SMVan Ryk DChaikin MAFauci AS
J Biol Chem
2002 Mar 29