Creating Biomedical Technologies to Improve Health

LABS AT NIBIB

Theranostic Nanomedicine Section

This is a collage of multi-functional nanomedicine platform. The Multi-functional nanoparticle can load siRNA and hydrophobic anticancer drugs simultaneously and can deliver the multiple cargos into cancer cells
Multi-functional nanomedicine platform (Angewandte Chemie International Edition cover art): Multi-functional nanoparticle (Zn-DPA-labeled HA-NP, HADPA-Zn-NP) can load siRNA and hydrophobic anticancer drugs simultaneously and can deliver the multiple cargos into cancer cells (Angew Chem Int Ed Engl. 2012 Jan 9;51(2):445-9).

Theranostic Nanomedicine is the medical application of nanobiotechnology and refers to highly specific medical intervention at the nanoscale for diagnosing, curing or preventing diseases. Theranostic Nanomedicine involves the creation and application of nanobiomaterials and devices at the molecular level for personalized diagnosis, imaging and therapy.

Using a multidisciplinary approach, our lab builds new systems for various nanobiomedical applications ranging from the medical use of nanoplatform-based diagnostic agents, to therapeutic agents, and even possible future applications of theranostics (diagnosis + therapy). By integrating state-of-the-art molecular imaging and nanomedicine with peptide/protein chemistry, polymer/inorganic chemistry, nanobioconjugation chemistry, cell/molecular biology as well as clinical medicine, we are developing future nanoplatforms which enable i) early detection of diseases, ii) monitoring therapeutic response, and iii) targeted delivery of therapeutic agents. Its improved practical potency highlights its potential as new personalized strategies to help improve patient management and outcomes in the near future.