Creating Biomedical Technologies to Improve Health

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Science Highlights • May 31, 2011
Damaged cartilage heals slowly, if at all. University of Pennsylvania bioengineers are using stem cells from patients’ bone marrow encapsulated in hydrogels to make replacement cartilage tissue in the laboratory. The technology may help the millions of Americans who suffer from osteoarthritis and cartilage injury.
Press Releases • May 23, 2011
In this first-in-human study the investigators proposed to explore the possibility of humans regaining standing and stepping functions (as observed previously in animals) through a combination of epidural stimulation with motor training. In year 2 of the award, the first implanted human subject is now able to stand and move his previously paralyzed lower limbs.
Science Highlights • April 29, 2011
A new technology based on radiolytic labeling and mass spectrometry yielded the first high-resolution structural model of a potassium channel in open and closed positions. The model will improve scientists’ understanding of ion flow through potassium channels, a crucial component of heart and nerve function.
Science Highlights • March 30, 2011
Researchers at Brigham and Women’s Hospital/Harvard Medical School and MIT engineered a targeted nanoparticle platform that may improve chemotherapy effectiveness. The platform delivers higher amounts of drugs precisely where they are needed with fewer side effects.
Science Highlights • February 28, 2011
Pregnant women in rural and underserved areas in the United States and overseas could benefit from access to low-cost ultrasound equipment. A new approach to making transducers developed by researchers at General Electric’s Global Research Center in Niskayuna, New York, has the potential to reduce ultrasound system costs and increase access to prenatal ultrasound.
Science Highlights • January 31, 2011
Early detection can be a matter of life and death for a cancer patient. To make cancer screening accessible to more patients, Rice University scientists and collaborators designed a low-cost portable microendoscope that enables detecting cancerous tissue at the point of care. The device may also be used to direct physicians where to take a diagnostic biopsy, aid in prognosis, and monitor treatment.
Science Highlights • December 22, 2010
Rapid, sensitive screening of biomolecules allows researchers to ask new questions about why diseases begin and how they progress. Investigators at the Massachusetts Institute of Technology have developed a fabrication technique and a screening system that match the accuracy of current molecular screening tests but are faster, less expensive, and easier to use.
Science Highlights • November 30, 2010
Blood passing through a hemodialysis machine has a tendency to clot. University of Pennsylvania researchers discovered that the clotting is connected to an immune reaction to biomaterials used in the machine’s tubing and filters. They devised two strategies to tame the immune reaction and thereby reduce blood clotting.
Science Highlights • October 29, 2010
An implantable biosensor (cell-based neurotransmitter fluorescent engineered reporter, CNiFER) allows real-time monitoring of biochemical activity in the brain.
Science Highlights • September 30, 2010
Millions of people living in low-resource settings go undiagnosed because they do not have access to diagnostics laboratories. Point-of-care diagnostic technologies are turning the table on this trend, bringing preventive screening, disease diagnostics, and disease monitoring tests to the field.

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