Biological Molecular Imaging Section

The Biological Molecular Imaging Section (BMIS) focuses on the identification of disease-specific biomarkers; development of new molecular imaging probes with cellular and molecular biology oriented techniques and methods; application of the developed probes into multimodality imaging; and collaborates with the other two LOMIN sections to characterize novel imaging or therapeutic agents, both in vitro and in vivo.

Target Identification and Probe Development
This is an image of a cardiac infarction in a rat as visualized by a combined PET and CT scan. The rat with the infarction has more accumulation of the PET probe than the control rat.

Molecular imaging allows detection of specific targets in vivo, including visualization of the presence of targets, as well as the quantification of their spatial and temporal distribution. A target may be a single key protein or a particular pathway related to certain pathological processes.  Our lab develops probes of small organic molecules, polypeptides, proteins, antibodies or aptamers by phage peptide display library screening, single chain antibody library screening, and systematic evolution of ligands by exponential enrichment (SELEX). The newly developed probes are then modified and optimized for in vivo molecular imaging application.

Protein Engineering and Site-specific Labeling

Fluorophores, isotopes, and other detectable labels are most commonly introduced into a protein through in vitro modifications with suitable amine or thiol reactive reagents. Non-specific labeling of protein probes will cause heterogeneity and inaccuracy of quantification in the imaging process. Our lab engineers protein probes to accomplish site-specific modification. For example, with a system utilizing an mRNA template with an amber codon (UAG), instead of a normal initiating codon (AUG) and a complementary misaminoacylated initiator suppressor tRNA capable of initiating protein synthesis from the UAG codon, an artificial amino acid can be introduced into the N-terminal of synthesized proteins. Enzymatic post-translational modification of proteins utilizing inteins-mediated protein splicing is an alternative approach for site-specific labeling.

Therapeutic Response Monitoring
This picture contains multiple sequential images of rat PET scans showing changes in a tumor following treatment.

Therapeutic efficacy is a key question that needs to be answered for ever drug or drug candidate. Molecular imaging is able to provide information to evaluate pharmacological effects. For instance, solid tumors are often characterized by having high glucose utilization, tumor cell proliferation, hypoxia with sustained angiogenesis and evasion of apoptosis. The influence of compounds targeting these characteristics of cancer biology can be selectively visualized by molecular imaging techniques. Examples include FDG PET to image glucose transport and metabolism, and FLT PET to evaluate the proliferating status. Additionally, some imaging strategies can focus on one particular pathway such as apoptosis and hypoxia or a single molecular target to access specific drugs.

Reporter Gene Based Imaging
This is 8 sequential images of a mouse using bioluminescence imaging to reveal caspase activation following treatment with one dose of doxorubicin

As a unique branch of molecular imaging, various reporter genes have been developed, and expression of reporter genes can be evaluated by multiple imaging modalities, including optical imaging, SPECT/PET or MRI. With split reporter gene or bioluminescence resonance energy transfer (BRET) system, protein-protein interactions can be visualized in living organisms.  Our lab develops and applies reporter gene imaging to corroborate probe-based non-invasive imaging.

Olympus Fluoview FV10i Confocol Microscope

 

Siemens Inveon Docked PET/CT

The Biological Molecular Imaging Section is physically located in building 9 and building 10, room B3B25.

The laboratory is equipped with instruments to perform cell biology and molecular biology experiments, such as cell culture, western blot, PCR, and gene and protein engineering. A Zeiss Axio Imager A2 LED upright bright field microscope is equipped for tissue staining and histological observation. An Olympus X-81 epifluorescent microscope and an Olympus Fluoview F10i-LIV fully automated confocal laser-scanning microscope allow us to investigate fluorophores label probes in tissue section or live cells. The surgery and imaging room 10/B3B25 is equipped with a cryomicrotome, a storage phosphor system, gamma counters, and liquid scintillation counters for ex vivo investigation.

Meastro II In Vivo Optical Imaging System

 

IVIS Lumina II In Vivo Optical Imaging System

The lab is also equipped with a stereotaxic mounted cortical impactor, a surgical microscope, a rodent ventilator and a body temperature controller for animal model establishment including traumatic brain injury (TBI), myocardial infarction (MI), hindlimb ischemia and various orthotopic tumor inoculation.

For live animal imaging, we are equipped with a Siemens Inveon PET/CT docking system to explore radiolabeled tracers, a CRI Maestro II for fluorescence imaging, and an IVIS Lumina II for both bioluminescence imaging and fluorescence imaging. We also get access to the NIH/MIF (Mouse Imaging Facility) to perform MRI imaging. Recently, we have installed a Vevo 2100 high frequency ultrasound system with integrated Vevo LAZR for ultrasound and photoacoustic (PA) imaging.


Tang LYu FTang BYang ZFan WZhang MWang ZJacobson OZhou ZLi LLiu YKiesewetter DOTang WHe LMa YNiu GZhang XChen X
ACS Appl Mater Interfaces
2019 Aug 07


Zhang JTian YLi DNiu GLang LLi FLiu YZhu ZChen X
Eur. J. Nucl. Med. Mol. Imaging
2019 Sep

Liu YGong CSLin LZhou ZLiu YYang ZShen ZYu GWang ZWang SMa YFan WHe LNiu GDai YChen X
Theranostics
2019

Lin LSHuang TSong JOu XYWang ZDeng HTian RLiu YWang JFLiu YYu GZhou ZWang SNiu GYang HHChen X
J. Am. Chem. Soc.
2019 Jun 26

Zhang MJacobson OKiesewetter DOMa YWang ZLang LTang LKang FDeng HYang WNiu GWang JChen X
Bioconjug. Chem.
2019 Jun 19

Hu RLi HLei ZHan QYu XZhou NZhang XMao YWang XIrwin DMNiu GTan H
Biotechnol. Bioeng.
2019 Jun 10



Zhou ZBai RWang ZBryant HLang LMerkle HMunasinghe JTang LTang WTian RYu GMa YNiu GGao JChen X
Bioconjug. Chem.
2019 Jun 19

Caisova VLi LGupta GJochmanova IJha AUher OHuynh TTMiettinen MPang YAbunimer LNiu GChen XGhayee HKTaïeb DZhuang ZZenka JPacak K
Cancers (Basel)
2019 May 11

Tian RZhu SZeng QLang LMa YKiesewetter DOLiu YFu XLau JZhu GJacobson OWang ZDai YYu GBrooks BRLiu GNiu GChen X
Bioconjug. Chem.
2019 Jun 19

Tang WFan WWang ZZhang WZhou SLiu YYang ZShao EZhang GJacobson OShan LTian RCheng SLin LDai YShen ZNiu GXie JChen X
ACS Nano
2019 May 28

Wang JZang JWang HLiu QLi FLin YHuo LJacobson ONiu GFan XZhu ZChen X
Clin Nucl Med
2019 Jun

Li LYang ZZhu SHe LFan WTang WZou JShen ZZhang MTang LDai YNiu GHu SChen X
Adv. Mater. Weinheim
2019 May


Tang LYang ZZhou ZMa YKiesewetter DOWang ZFan WZhu SZhang MTian RLang LNiu GZhang XChen X
Theranostics
2019

Yang WZhu GWang SYu GYang ZLin LZhou ZLiu YDai YZhang FShen ZLiu YHe ZLau JNiu GKiesewetter DOHu SChen X
ACS Nano
2019 Mar 26

Yang ZSong JTang WFan WDai YShen ZLin LCheng SLiu YNiu GRong PWang WChen X
Theranostics
2019

Tian RMa HYang QWan HZhu SChandra SSun HKiesewetter DONiu GLiang YChen X
Chem Sci
2019 Jan 07

Han QHu RLi HLei ZZhang XYu XZhang QMao YWang XIrwin DMNiu GTan H
Biotechnol. Bioeng.
2019 Jun

Lau JJacobson ONiu GLin KSBénard FChen X
Bioconjug. Chem.
2019 Mar 20

Xie FPLiu HHChen JMNiu GLin LSWu Y
Shanghai Kou Qiang Yi Xue
2018 Aug

Tang WFan WWang ZZhang WZhou SLiu YYang ZShao EZhang GJacobson OShan LTian RCheng SLin LDai YShen ZNiu GXie JChen X
ACS Nano
2018 Dec 26

Shen ZLiu TLi YLau JYang ZFan WZhou ZShi CKe CBregadze VIMandal SKLiu YLi ZXue TZhu GMunasinghe JNiu GWu AChen X
ACS Nano
2018 Nov 27

Hou YLi XLi QXu JYang HXue MNiu GZhuo SMu KWu GLi XWang HZhu JZhuang T
J. Cell. Mol. Med.
2018 Dec

Niu GWang GLau JLang LJacobson OMa YKiesewetter DOZhang SChen X
Adv Healthc Mater
2019 Jun


Cheng SJacobson OZhu GChen ZLiang SHTian RYang ZNiu GZhu XChen X
Eur. J. Nucl. Med. Mol. Imaging
2018 Nov

Zhu SYung BCChandra SNiu GAntaris ALChen X
Theranostics
2018


Zhang XLi HYu XLi SLei ZLi CZhang QHan QLi YZhang KWang YLiu CMao YWang XIrwin DMGuo HNiu GTan H
Cell. Physiol. Biochem.
2018

Zang JFan XWang HLiu QWang JLi HLi FJacobson ONiu GZhu ZChen X
Eur. J. Nucl. Med. Mol. Imaging
2019 Jan

Cheng SJacobson OZhu GChen ZLiang SHTian RYang ZNiu GZhu XChen X
Eur. J. Nucl. Med. Mol. Imaging
2019 Apr

Liang OWang PXia MAugello CYang FNiu GLiu HXie YH
Biosens Bioelectron
2018 Oct 30

Li DZhang JJi NZhao XZheng KQiao ZLi FLang LIagaru ANiu GZhu ZChen X
Clin Nucl Med
2018 Sep

Liu YYang ZHuang XYu GWang SZhou ZShen ZFan WLiu YDavisson MKalish HNiu GNie ZChen X
ACS Nano
2018 Aug 28

Zhu SHu ZTian RYung BCYang QZhao SKiesewetter DONiu GSun HAntaris ALChen X
Adv. Mater. Weinheim
2018 Jul 09

Liu ZZhang JXu JYang HLi XHou YZhao YXue MWang BYu NYu SNiu GWu GLi XWang HZhu JZhuang T
J. Cell. Mol. Med.
2018 Sep

Shen ZSong JZhou ZYung BCAronova MALi YDai YFan WLiu YLi ZRuan HLeapman RDLin LNiu GChen XWu A
Adv. Mater. Weinheim
2018 Jul 04


Zhao JNiu GRen WWang LDong GZhang NLiu MYe ZG
ACS Appl Mater Interfaces
2018 Jul 18


Liu HZhou ZLi XLi CWang RZhang YNiu G
Br J Radiol
2018 Nov

Wang ZJacobson OTian RMease RCKiesewetter DONiu GPomper MGChen X
Bioconjug. Chem.
2018 Jul 18


Thompson SJPitcher MHStone LSTarum FNiu GChen XKiesewetter DOSchweinhardt PBushnell MC
Pain
2018 Sep

Li DZhang JChi CXiao XWang JLang LAli INiu GZhang LTian JJi NZhu ZChen X
Theranostics
2018

Wu JWang SZhang XTeng ZWang JYung BCNiu GZhu HLu GChen X
J. Nucl. Med.
2018 Dec

Zhang CYNiu GJin YYYu HCheng H
Shanghai Kou Qiang Yi Xue
2017 Dec


Zhang FNi QJacobson OCheng SLiao AWang ZHe ZYu GSong JMa YNiu GZhang LZhu GChen X
Angew. Chem. Int. Ed. Engl.
2018 Jun 11


Niu GChen X
Nat Nanotechnol
2018 May


Wang ZGao HZhang YLiu GNiu GChen X
Front Chem Sci Eng
2017 Dec

Lin LSSong JSong LKe KLiu YZhou ZShen ZLi JYang ZTang WNiu GYang HHChen X
Angew. Chem. Int. Ed. Engl.
2018 Apr 23

Zhang JMao FNiu GPeng LLang LLi FYing HWu HPan BZhu ZChen X
Theranostics
2018

Zhu CWang MNiu GYang JWang Z
Taiwan J Obstet Gynecol
2018 Feb

Tang WYang ZWang SWang ZSong JYu GFan WDai YWang JShan LNiu GFan QChen X
ACS Nano
2018 Mar 27

Yang HYu NXu JDing XDeng WWu GLi XHou YLiu ZZhao YXue MYu SWang BLi XNiu GWang HZhu JZhuang T
J. Exp. Clin. Cancer Res.
2018 Feb 12



Lu NFan WYi XWang SWang ZTian RJacobson OLiu YYung BCZhang GTeng ZYang KZhang MNiu GLu GChen X
ACS Nano
2018 Feb 27

Tian RJacobson ONiu GKiesewetter DOWang ZZhu GMa YLiu GChen X
Theranostics
2018

Ni QZhang FZhang YZhu GWang ZTeng ZWang CYung BCNiu GLu GZhang LChen X
Adv. Mater. Weinheim
2018 Mar


Dai YYang ZCheng SWang ZZhang RZhu GWang ZYung BCTian RJacobson OXu CNi QSong JSun XNiu GChen X
Adv. Mater. Weinheim
2018 Feb

Yang XLiu ZZhang HLi ZMunasinghe JPNiu GTeng GChen X
Eur. J. Nucl. Med. Mol. Imaging
2018 Apr

Wang ZDai YWang ZJacobson OZhang FYung BCZhang PGao HNiu GLiu GChen X
Nanoscale
2018 Jan 18



Zhu GLynn GMJacobson OChen KLiu YZhang HMa YZhang FTian RNi QCheng SWang ZLu NYung BCWang ZLang LFu XJin AWeiss IDVishwasrao HNiu GShroff HKlinman DMSeder RAChen X
Nat Commun
2017 Dec 05

Chen WTian RXu CYung BCWang GLiu YNi QZhang FZhou ZWang JNiu GMa YFu LChen X
Nat Commun
2017 Nov 24


Zhang YZhou NYu XZhang XLi SLei ZHu RLi HMao YWang XZhang JLi YGuo HIrwin DMNiu GTan H
Oncotarget
2017 Oct 10

Zhu GMei LVishwasrao HDJacobson OWang ZLiu YYung BCFu XJin ANiu GWang QZhang FShroff HChen X
Nat Commun
2017 Nov 14

Zhang JNiu GFan XLang LHou GChen LWu HZhu ZLi FChen X
J. Nucl. Med.
2018 Jun

Zhuang TYu SZhang LYang HLi XHou YLiu ZShi YWang WYu NLi ALi XLi XNiu GXu JHasni MSMu KWang HZhu J
Oncotarget
2017 Sep 29

Wu YXie FPLiu HHGang NChen JMLin LS
Shanghai Kou Qiang Yi Xue
2017 Jun



Liu YWang ZLiu YZhu GJacobson OFu XBai RLin XLu NYang XFan WSong JWang ZYu GZhang FKalish HNiu GNie ZChen X
ACS Nano
2017 Oct 24

Zhang FZhu GJacobson OLiu YChen KYu GNi QFan JYang ZXu FFu XWang ZMa YNiu GZhao XChen X
ACS Nano
2017 Sep 26

Zhao JRen WNiu GZhang NDong GWang LLiu MShi PYe ZG
ACS Appl Mater Interfaces
2017 Aug 30

Chen HTong XLang LJacobson OYung BCYang XBai RKiesewetter DOMa YWu HNiu GChen X
Theranostics
2017


Jacobson OLi QChen HNiu GKiesewetter DOXu LCook KYang GDall'Acqua WTsui PPeng LChen X
J. Nucl. Med.
2017 Nov



Ni YCao BMa TNiu GHuo YHuang JChen DLiu YYu BZhang MQNiu H
Elife
2017 May 09

Zhou ZSong JTian RYang ZYu GLin LZhang GFan WZhang FNiu GNie LChen X
Angew. Chem. Int. Ed. Engl.
2017 Jun 01

Long XZhang JZhang DGao CChi CYang EXue HLang LNiu GZhu ZLi FChen X
Eur. J. Nucl. Med. Mol. Imaging
2017 Aug

Kim YHMin KHWang ZKim JJacobson OHuang PZhu GLiu YYung BNiu GChen X
Theranostics
2017

Yang ZTian RWu JFan QYung BCNiu GJacobson OWang ZLiu GYu GHuang WSong JChen X
ACS Nano
2017 Apr 25

Lin LSYang XZhou ZYang ZJacobson OLiu YYang ANiu GSong JYang HHChen X
Adv. Mater. Weinheim
2017 Jun

Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X
Mol. Pharm.
2017 Apr 03

Zhu GZhang FNi QNiu GChen X
ACS Nano
2017 Mar 28

Lu NHuang PFan WWang ZLiu YWang SZhang GHu JLiu WNiu GLeapman RDLu GChen X
Biomaterials
2017 May

Zhu GZhang HJacobson OWang ZChen HYang XNiu GChen X
Bioconjug. Chem.
2017 Apr 19


Yang HYu SWang WLi XHou YLiu ZShi YMu KNiu GXu JWang HZhu JZhuang T
Neoplasia
2017 Feb

Yang XWang ZZhang FZhu GSong JTeng GJNiu GChen X
Theranostics
2017

Zhang SHan YZhu XShang SHuang GZhang LNiu GWang SHe XWan M
Ultrasound Med Biol
2017 Feb

Xu CYang XFu XTian RJacobson OWang ZLu NLiu YFan WZhang FNiu GHu SAli IUChen X
Adv. Mater. Weinheim
2017 Feb

Chen HJacobson ONiu GWeiss IDKiesewetter DOLiu YMa YWu HChen X
J. Nucl. Med.
2017 Apr


Di Bartolomeo APassacantando MNiu GSchlykow VLupina GGiubileo FSchroeder T
Nanotechnology
2016 Dec 02


Tong XWang ZSun XSong JJacobson ONiu GKiesewetter DOChen X
Theranostics
2016

Niu GCapellini GHatami FDi Bartolomeo ANiermann THussein EHSchubert MAKrause HMZaumseil PSkibitzki OLupina GMasselink WTLehmann MXie YHSchroeder T
ACS Appl Mater Interfaces
2016 Oct 12

Gao QWang ZCDuan MLin YHZhou XYWorthley DLWang XYNiu GXia YDeng MLiu LZShi JYYang LXZhang SDing ZBZhou JLiang CMCao YXiong LXi RShi YYFan J
Gastroenterology
2017 Jan

Li HMao YZhang QHan QMan ZZhang JWang XHu RZhang XIrwin DMNiu GTan H
J Ethnopharmacol
2016 Nov 04

Tong XSrivatsan AJacobson OWang YWang ZYang XNiu GKiesewetter DOZheng HChen X
Sci Rep
2016 Aug 22


Watson DCBayik DSrivatsan ABergamaschi CValentin ANiu GBear JMonninger MSun MMorales-Kastresana AJones JCFelber BKChen XGursel IPavlakis GN
Biomaterials
2016 Oct

Venugopalan ALee MJNiu GMedina-Echeverz JTomita YLizak MJCultraro CMSimpson RMChen XTrepel JBGuha U
Oncotarget
2016 Aug 23

Zhang JNiu GLang LLi FFan XYan XYao SYan WHuo LChen LLi ZZhu ZChen X
J. Nucl. Med.
2017 Feb


Fan JHe QLiu YZhang FYang XWang ZLu NFan WLin LNiu GHe NSong JChen X
ACS Appl Mater Interfaces
2016 Jun 08

Niu GCalka PAuf der Maur MSantoni FGuha SFraschke MHamoumou PGautier BPerez EWalczyk CWenger CDi Carlo AAlff LSchroeder T
Sci Rep
2016 May 16

Sasaki HNoh YKNiu GSugiyama M
Neural Comput
2016 Jun

Qin FLu XFeng YTang PNiu GLi FZhang J
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
2016 Apr

Zhu GLiu YYang XKim YHZhang HJia RLiao HSJin ALin JAronova MLeapman RNie ZNiu GChen X
Nanoscale
2016 Mar 28

Niu GCapellini GSchubert MANiermann TZaumseil PKatzer JKrause HMSkibitzki OLehmann MXie YHvon Känel HSchroeder T
Sci Rep
2016 Mar 04

Lin JWang MHu HYang XWen BWang ZJacobson OSong JZhang GNiu GHuang PChen X
Adv. Mater. Weinheim
2016 May

Chen HWang GLang LJacobson OKiesewetter DOLiu YMa YZhang XWu HZhu LNiu GChen X
Theranostics
2016

Wang ZHuang PJacobson OWang ZLiu YLin LLin JLu NZhang HTian RNiu GLiu GChen X
ACS Nano
2016 Mar 22

Li JBKong LZYang JBNiu GFan LHuang JZChen SQ
Medicine (Baltimore)
2016 Feb





Niu GCapellini GLupina GNiermann TSalvalaglio MMarzegalli ASchubert MAZaumseil PKrause HMSkibitzki OLehmann MMontalenti FXie YHSchroeder T
ACS Appl Mater Interfaces
2016 Jan 27

You TOu XNiu GBärwolf FLi GDu NBürger DSkorupa IJia QYu WWang XSchmidt OGSchmidt H
Sci Rep
2015 Dec 22



Liu ZChen HChen KShao YKiesewetter DONiu GChen X
Sci Adv
2015 Sep

Xia MLi BYin KCapellini GNiu GGong YZhou WAjayan PMXie YH
ACS Nano
2015 Dec 22

Zhang JLi DLang LZhu ZWang LWu PNiu GLi FChen X
J. Nucl. Med.
2016 Jan

Zheng KLiang NZhang JLang LZhang WLi SZhao JNiu GLi FZhu ZChen X
J. Nucl. Med.
2015 Dec

Rong PHuang PLiu ZLin JJin AMa YNiu GYu LZeng WWang WChen X
Nanoscale
2015 Oct 21

Kuschel ODieck FWilkens HGevers SRodewald JOtte CZoellner MHNiu GSchroeder TWollschläger J
Materials (Basel)
2015 Sep 18


Niu GZoellner MHSchroeder TSchaefer AJhang JHZielasek VBäumer MWilkens HWollschläger JOlbrich RLammers CReichling M
Phys Chem Chem Phys
2015 Oct 14

Jacobson OWeiss IDWang LWang ZYang XDewhurst AMa YZhu GNiu GKiesewetter DOVasdev NLiang SHChen X
J. Nucl. Med.
2015 Nov


Huang PGao YLin JHu HLiao HSYan XTang YJin ASong JNiu GZhang GHorkay FChen X
ACS Nano
2015 Oct 27

Zhang JLang LZhu ZLi FNiu GChen X
J. Nucl. Med.
2015 Oct


Song JYang XJacobson OHuang PSun XLin LYan XNiu GMa QChen X
Adv. Mater. Weinheim
2015 Sep 02


Yan XNiu GWang ZYang XKiesewetter DOJacobson OShen BChen X
Mol Imaging Biol
2016 Feb

Yu CPan DMi BXu YLang LNiu GYang MWan WChen X
Eur. J. Nucl. Med. Mol. Imaging
2015 Dec

Jacobson OYan XMa YNiu GKiesewetter DOChen X
Bioconjug. Chem.
2015 Oct 21

Zhu GNiu GChen X
Bioconjug. Chem.
2015 Nov 18


Zhou NZhang YZhang XLei ZHu RLi HMao YWang XIrwin DMNiu GTan H
Int J Mol Sci
2015 May 26

Wang ZZhang MWang LWang SKang FLi GJacobson ONiu GYang WWang JChen X
Theranostics
2015

Wang ZWang FHida NKiesewetter DOTian JNiu GChen X
Nat Protoc
2015 May


Guo NZhang FZhang XGuo JLang LKiesewetter DONiu GLi QChen X
Mol Imaging Biol
2015 Dec

Jin LGuo TLi ZLei ZLi HMao YWang XZhou NZhang YHu RZhang XNiu GIrwin DMTan H
Int J Mol Sci
2015 Apr 02



Huanxiao ZShuqin CHongye JHongzhe XGang NChengkang XXiaoming GShuzhong Y
Gynecol Surg
2015

Jacobson OYan XNiu GWeiss IDMa YSzajek LPShen BKiesewetter DOChen X
J. Nucl. Med.
2015 Apr


Yan XHu HLin JJin AJNiu GZhang SHuang PShen BChen X
Nanoscale
2015 Feb 14



Yan XNiu GLin JJin AJHu HTang YZhang YWu ALu JZhang SHuang PShen BChen X
Biomaterials
2015 Feb

Wang YLang LHuang PWang ZJacobson OKiesewetter DOAli IUTeng GNiu GChen X
Proc. Natl. Acad. Sci. U.S.A.
2015 Jan 06

Wang ZZhang RWang ZWang HFWang YZhao JWang FLi WNiu GKiesewetter DOChen X
ACS Nano
2014 Dec 23





Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X
Mol. Pharm.
2014 Nov 03

Niu GHildebrandt ESchubert MABoscherini FZoellner MHAlff LWalczyk DZaumseil PCostina IWilkens HSchroeder T
ACS Appl Mater Interfaces
2014 Oct 22

Hu HHuang PWeiss OJYan XYue XZhang MGTang YNie LMa YNiu GWu KChen X
Biomaterials
2014 Dec

Wang YYue XKiesewetter DOWang ZLu JNiu GTeng GChen X
Mol. Pharm.
2014 Oct 06

Li WSun XWang YNiu GChen XQian ZNie L
Biomed Opt Express
2014 Aug 01

Huang PRong PJin AYan XZhang MGLin JHu HWang ZYue XLi WNiu GZeng WWang WZhou KChen X
Adv. Mater. Weinheim
2014 Oct 08

Sun XHuang XYan XWang YGuo JJacobson OLiu DSzajek LPZhu WNiu GKiesewetter DOSun SChen X
ACS Nano
2014 Aug 26

Calandriello DNiu GSugiyama M
Neural Netw
2014 Sep

Luo LChen SQJiang HYNiu GWang QYao SZ
Eur. J. Obstet. Gynecol. Reprod. Biol.
2014 Aug

Liu DYang JWang HFWang ZHuang XWang ZNiu GHight Walker ARChen X
Anal. Chem.
2014 Jun 17


Niu GLang LKiesewetter DOMa YSun ZGuo NGuo JWu CChen X
J. Nucl. Med.
2014 Jul

Huang PRong PLin JLi WYan XZhang MGNie LNiu GLu JWang WChen X
J. Am. Chem. Soc.
2014 Jun 11

Zhen ZTang WChuang YJTodd TZhang WLin XNiu GLiu GWang LPan ZChen XXie J
ACS Nano
2014 Jun 24


Wang ZYue XWang YQian CHuang PLizak MNiu GWang FRong PKiesewetter DOMa YChen X
Adv Healthc Mater
2014 Aug

Huang XZhang FWang YSun XChoi KYLiu DChoi JSShin THCheon JNiu GChen X
ACS Nano
2014 May 27

Bhirde AAChikkaveeraiah BVSrivatsan ANiu GJin AJKapoor AWang ZPatel SPatel VGorbach AMLeapman RDGutkind JSHight Walker ARChen X
ACS Nano
2014 May 27

Wang FWang ZHida NKiesewetter DOMa YYang KRong PLiang JTian JNiu GChen X
Proc. Natl. Acad. Sci. U.S.A.
2014 Apr 08


Wang YYue XKiesewetter DONiu GTeng GChen X
Eur. J. Nucl. Med. Mol. Imaging
2014 Jul


Rong PYang KSrivastan AKiesewetter DOYue XWang FNie LBhirde AWang ZLiu ZNiu GWang WChen X
Theranostics
2014



Wang ZWang ZLiu DYan XWang FNiu GYang MChen X
Angew. Chem. Int. Ed. Engl.
2014 Feb 10

Sun XHuang XGuo JZhu WDing YNiu GWang AKiesewetter DOWang ZLSun SChen X
J. Am. Chem. Soc.
2014 Feb 05

Huang XZhang FSun XChoi KYNiu GZhang GGuo JLee SChen X
Biomaterials
2014 Jan

Huang PLin JLi WRong PWang ZWang SWang XSun XAronova MNiu GLeapman RDNie ZChen X
Angew. Chem. Int. Ed. Engl.
2013 Dec 23

Zhu LMa YKiesewetter DOWang YLang LLee SNiu GChen X
ACS Chem. Biol.
2014 Feb 21

Chen JTang DWang SLi QGZhang JRLi PLu QNiu GGao JYe NYWang DR
Tumour Biol.
2014 Mar


Zhang XLi HMao YLi ZWang RGuo TJin LSong RXu WZhou NZhang YHu RWang XHuang HLei ZNiu GIrwin DMTan H
PLoS ONE
2013

Liu DWang ZJin AHuang XSun XWang FYan QGe SXia NNiu GLiu GHight Walker ARChen X
Angew. Chem. Int. Ed. Engl.
2013 Dec 23

Sugiyama MNiu GYamada MKimura MHachiya H
Neural Comput
2014 Jan


Guo JLang LHu SGuo NZhu LSun ZMa YKiesewetter DONiu GXie QChen X
Mol Imaging Biol
2014 Apr

Song RWang XMao YLi HLi ZXu WWang RGuo TJin LZhang XZhang YZhou NHu RJia JLei ZIrwin DMNiu GTan H
Gene
2013 Oct 15

Wu CLi FNiu GChen X
Theranostics
2013


Guirguis EHockman SChung YWAhmad FGavrilova ORaghavachari NYang YNiu GChen XYu ZXLiu SDegerman EManganiello V
Endocrinology
2013 Sep

Wang ZNiu GChen X
Pharm. Res.
2014 Jun

Lu JFrerich JMTurtzo LCLi SChiang JYang CWang XZhang CWu CSun ZNiu GZhuang ZBrady ROChen X
Proc. Natl. Acad. Sci. U.S.A.
2013 Jun 25


Huang XZhang FZhu LChoi KYGuo NGuo JTackett KAnilkumar PLiu GQuan QChoi HSNiu GSun YPLee SChen X
ACS Nano
2013 Jul 23

Wang ZZhang XHuang PZhao WLiu DNie LYue XWang SMa YKiesewetter DNiu GChen X
Biomaterials
2013 Aug



Liu DHuang XWang ZJin ASun XZhu LWang FMa YNiu GHight Walker ARChen X
ACS Nano
2013 Jun 25

Zhang CLi CZhu MZhang QXie ZNiu GSong XJin LLi GZheng H
PLoS ONE
2013

Zhang XXSun ZGuo JWang ZWu CNiu GMa YKiesewetter DOChen X
Mol Imaging Biol
2013 Dec

Ye ZCao QNiu GLiang YLiu YJiang LYu XHan A
J. Clin. Pathol.
2013 Aug

Cai YZhu LZhang FNiu GLee SKimura SChen X
Mol. Pharm.
2013 Jun 03

Chen SHuang PWang ZWang ZSwierczewska MNiu GCui DChen X
Nanoscale Res Lett
2013 Apr 12

Huang PLin JWang SZhou ZLi ZWang ZZhang CYue XNiu GYang MCui DChen X
Biomaterials
2013 Jun

Xu WLi HWang RLei ZMao YWang XZhang YGuo TSong RZhang XJin LLi ZIrwin DMNiu GTan H
Int J Mol Sci
2013 Mar 21

Niu GZhu LHo DNZhang FGao HQuan QHida NOzawa TLiu GChen X
Theranostics
2013

Wang SHuang PNie LXing RLiu DWang ZLin JChen SNiu GLu GChen X
Adv. Mater. Weinheim
2013 Jun 11




Huang XZhang FWang HNiu GChoi KYSwierczewska MZhang GGao HWang ZZhu LChoi HSLee SChen X
Biomaterials
2013 Feb

Kiesewetter DOGuo NGuo JGao HZhu LMa YNiu GChen X
Theranostics
2012

Gao HKiesewetter DOZhang XHuang XGuo NLang LHida NWang HWang HCao FNiu GChen X
J. Nucl. Med.
2012 Dec


Guo TMao YLi HWang XXu WSong RJia JLei ZIrwin DMNiu GTan H
Biomed. Pharmacother.
2012 Dec

Wang YGuo TZhao SLi ZMao YLi HWang XWang RXu WSong RJin LLi XIrwin DMNiu GTan H
PLoS ONE
2012

Mohamedali KANiu GLuster TAThorpe PEGao HChen XRosenblum MG
Biochem. Pharmacol.
2012 Dec 01

He SYShen HWXu LZhao XHYuan LNiu GYou ZSYao SZ
Gynecol. Oncol.
2012 Dec

Wang ZHuang PBhirde AJin AMa YNiu GNeamati NChen X
Chem. Commun. (Camb.)
2012 Oct 09

Zhu LGuo NLi QMa YJacboson OLee SChoi HSMansfield JRNiu GChen X
Theranostics
2012


Zhang FHuang XQian CZhu LHida NNiu GChen X
Biochem. Biophys. Res. Commun.
2012 Sep 07

Hong HZhang YSeverin GWYang YEngle JWNiu GNickles RJChen XLeigh BRBarnhart TECai W
Mol. Pharm.
2012 Aug 06

Wang HGao HGuo NNiu GMa YKiesewetter DOChen X
Theranostics
2012

Luo LNiu GWang QXie HZYao SZ
J Minim Invasive Gynecol
2012



Niu GMurad YMGao HHu SGuo NJacobson ONguyen TDZhang JChen X
J Control Release
2012 Jul 10

Zhang FHuang XZhu LGuo NNiu GSwierczewska MLee SXu HWang AYMohamedali KARosenblum MGLu GChen X
Biomaterials
2012 Jul



Huang XZhang FLee SSwierczewska MKiesewetter DOLang LZhang GZhu LGao HChoi HSNiu GChen X
Biomaterials
2012 Jun

Hu SKiesewetter DOZhu LGuo NGao HLiu GHida NLang LNiu GChen X
Mol Imaging Biol
2012 Dec

Srivastava SKashiwaya YKing MTBaxa UTam JNiu GChen XClarke KVeech RL
FASEB J.
2012 Jun


Yu XWZhang ZYang JZhang YLWang RNiu GGuo YM
Zhonghua Yi Xue Za Zhi
2011 Nov 22

Gao HLang LGuo NCao FQuan QHu SKiesewetter DONiu GChen X
Eur. J. Nucl. Med. Mol. Imaging
2012 Apr

Huang XSwierczewska MChoi KYZhu LBhirde APark JKim KXie JNiu GLee KCLee SChen X
Angew. Chem. Int. Ed. Engl.
2012 Feb 13


Kiesewetter DOGao HMa YNiu GQuan QGuo NChen X
Eur. J. Nucl. Med. Mol. Imaging
2012 Mar

Liu GChoi KYBhirde ASwierczewska MYin JLee SWPark JHHong JIXie JNiu GKiesewetter DOLee SChen X
Angew. Chem. Int. Ed. Engl.
2012 Jan 09

Li WNiu GLang LGuo NMa YKiesewetter DOBacker JMShen BChen X
Eur. J. Nucl. Med. Mol. Imaging
2012 Feb

Lang LLi WGuo NMa YZhu LKiesewetter DOShen BNiu GChen X
Bioconjug. Chem.
2011 Dec 21

Zhao THachiya HNiu GSugiyama M
Neural Netw
2012 Feb

Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOPeled AEden HSFarber JMChen X
J Control Release
2012 Jan 30

Lang LLi WJia HMFang DCZhang SSun XZhu LMa YShen BKiesewetter DONiu GChen X
Theranostics
2011

Liu GXie JZhang FWang ZLuo KZhu LQuan QNiu GLee SAi HChen X
Small
2011 Oct 04

Bhattacharjee AKLang LJacobson OShinkre BMa YNiu GTrenkle WCJacobson KAChen XKiesewetter DO
Nucl. Med. Biol.
2011 Aug

Quan QYang MGao HZhu LLin XGuo NZhang GEden HSNiu GChen X
Eur. J. Nucl. Med. Mol. Imaging
2011 Oct


Gao HNiu GYang MQuan QMa YMurage ENAhn JMKiesewetter DOChen X
Mol. Pharm.
2011 Oct 03

Zhang FZhu LLiu GHida NLu GEden HSNiu GChen X
Theranostics
2011

Zhang FNiu GLin XJacobson OMa YEden HSHe YLu GChen X
Amino Acids
2012 Jun

Zhu LXie JSwierczewska MZhang FLin XFang XNiu GLee SChen X
Bioconjug. Chem.
2011 Jun 15

Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOFarber JMChen X
Theranostics
2011


Yang MGao HZhou YMa YQuan QLang LChen KNiu GYan YChen X
Theranostics
2011


Wang FNiu GChen XCao F
Eur. J. Nucl. Med. Mol. Imaging
2011 Aug

Jacobson OWeiss IDNiu GBalboni GCongiu COnnis VKiesewetter DOLattanzi RSalvadori SChen X
J. Nucl. Med.
2011 Apr


Yang MGao HYan YSun XChen KQuan QLang LKiesewetter DNiu GChen X
Eur. J. Nucl. Med. Mol. Imaging
2011 Jul

Chen KSun XNiu GMa YYap LPHui XWu KFan DConti PSChen X
Mol Imaging Biol
2012 Feb

Jacobson OZhu LMa YWeiss IDSun XNiu GKiesewetter DOChen X
Bioconjug. Chem.
2011 Mar 16


Lin XXie JZhu LLee SNiu GMa YKim KChen X
Angew. Chem. Int. Ed. Engl.
2011 Feb 11

Liu GSwierczewska MNiu GZhang XChen X
Mol Biosyst
2011 Apr

Zhu LWang HWang LWang YJiang KLi CMa QGao SWang LLi WCai MWang HNiu GLee SYang WFang XChen X
J Control Release
2011 Mar 30

Yang MGao HSun XYan YQuan QZhang WMohamedali KARosenblum MGNiu GChen X
Mol. Pharm.
2011 Apr 04

Ye YZhu LMa YNiu GChen X
Bioorg. Med. Chem. Lett.
2011 Feb 15

Lin XXie JNiu GZhang FGao HYang MQuan QAronova MAZhang GLee SLeapman RChen X
Nano Lett.
2011 Feb 09

Jacobson OZhu LNiu GWeiss IDSzajek LPMa YSun XYan YKiesewetter DOLiu SChen X
Mol Imaging Biol
2011 Dec

Sun XYan YLiu SCao QYang MNeamati NShen BNiu GChen X
J. Nucl. Med.
2011 Jan

Niu GChen X
J. Nucl. Med.
2010 Nov

Zhang FNiu GLu GChen X
Mol Imaging Biol
2011 Aug

Sun XNiu GChan NShen BChen X
Mol Imaging Biol
2011 Jun

Karam JAHuang SFan JStanfield JSchultz RAPong RCSun XMason RPXie XJNiu GChen XFrenkel EPSagalowsky AIHsieh JT
Int. J. Cancer
2011 Jun 15

Gu DMa YNiu GYan YLang LAisa HAAisaand HAGao HKiesewetter DOChen X
Amino Acids
2011 Feb

Sun XNiu GYan YYang MChen KMa YChan NShen BChen X
Clin. Cancer Res.
2010 Aug 15



Cao QLiu SNiu GChen KYan YLiu ZChen X
Amino Acids
2011 Nov

Niu GSun XCao QCourter DKoong ALe QTGambhir SSChen X
Clin. Cancer Res.
2010 Apr 01


Xie JWang JNiu GHuang JChen KLi XChen X
Chem. Commun. (Camb.)
2010 Jan 21

Niu GChen X
PET Clin
2009 Jan 01







Liu ZNiu GWang FChen X
Eur. J. Nucl. Med. Mol. Imaging
2009 Sep




Niu GChen X
Drug Deliv (Lond)
2009




Veeravagu ALiu ZNiu GChen KJia BCai WJin CHsu ARConnolly AJTse VWang FChen X
Clin. Cancer Res.
2008 Nov 15





Yang YXiao MMao YLi HZhao SGu YWang RYu JZhang XIrwin DMNiu GTan H
Biomed. Pharmacother.
2009 Jun


Jiang LYao MShi JShen PNiu GFei J
J. Neurosci. Res.
2008 May 01


Cai WNiu GChen X
Eur. J. Nucl. Med. Mol. Imaging
2008 Jan





Yao SZChen SQXie HZNiu GChen YQLiu DQHuang JZ
Zhonghua Fu Chan Ke Za Zhi
2005 Sep


Cao QZNiu GTan HR
World J. Gastroenterol.
2005 Apr 21

Niu GKrager KJGraham MMHichwa RDDomann FE
Eur. J. Nucl. Med. Mol. Imaging
2005 May

Niu GGaut AWPonto LLHichwa RDMadsen MTGraham MMDomann FE
J. Nucl. Med.
2004 Mar