NIBIB organized a workshop at the National Institutes of Health (NIH), to explore concerns about the safety of gadolinium-based contrast agents (GBCAs) and gadolinium retention. The workshop was co-sponsored by NIH, the Radiological Society of North America (RSNA) and the American College of Radiology (ACR).
The research roadmap resulting from this workshop identifies knowledge gaps about gadolinium retention and prioritizes directions for needed research.
Read the report here.
Citation: Gadolinium Retention: A Research Roadmap from the 2018 NIH/ACR/RSNA Workshop on Gadolinium Chelates. McDonald RJ, Levine D, Weinreb J, Kanal E, Davenport MS, Ellis JH, Jacobs PM, Lenkinski RE, Maravilla KR, Prince MR, Rowley HA, Tweedle MF, Kressel HY. Radiology, Sept. 11, 2018.
Read companion viewpoint in the Sept. 12, 2018, Journal of the American Medical Associtation here.
Presenter Slides
Session 2 - Gadolinium Speciation
- Peter Caravan: Molecular Form(s) in Which Residual Gadolinium Might Exist and How It Might Differ Among Different GBCA; How to Measure Them In Vivo vs Ex Vivo
- Silvio Aime: Magnetic Methods
- Simon George: XAFS
- Hubertus Pietsch: HPLC and MALDI Imaging
- Michael Tweedle: Fluorescence and Radiotracer Methods
Session 3 - Lanthanide and Gadolinium Toxicity
- Adebayo Laniyonu: Overview of Lanthanide and Gadolinium Toxicology
- Robert Lenkinski: Chemical Properties of GBCA’s and the Use of Animal Models to Inform Us about Gadolinium Retention/Deposition in the Human Brain
- Jerry Abraham: Different Metals and Their Toxicity in Tissue
- Shawn Cowper: What We Can Learn from NSF about Broader Potential Toxicity
- Edward Neuwelt: Blood-Brain Barrier (BBB) and Seizures in Dogs
Session 4 - Gadolinium/GBCA Deposition and Retention in the Brain
- Manny Kanal: How Gadolinium Gets into the Brain
- Robert McDonald: Animal and Human Studies as well as Population Studies at Mayo
- Alexander Radbruch: Gadolinium Deposition in the Brain: Parallels between Patient, Animal, and In Vitro Studies
- Donna Roberts: Gadolinium in Postmortem Brain Tissue in Children Using ICP-MS and LA-ICP-MS
- Atle Bjornerud: Enhancement Effects in the Dentate Nucleus in Humans Following Very High Cumulative Doses of Dadobutrol
- Richard Davis: Postmortem Brain Specimens from the Pathology Perspective
- John Prybylski: Spatial (microscopic and gross) Distribution of Gd in Human and Animal Brains and How That Compares to Other Metals (both foreign and physiological)
Session 5 - Gadolinium/GBCA Deposition and Retention in Other Organs
- Karen Bleich: Fate of Various GBCAs and Gadolinium in the Liver, Bone, and Skin: Overview of Animal and Human Data
- Fiona McNeill: Devices to Measure Gd in Different Organs
- Davide Zanon: Possible Link between Iron Overload and Gadolinium Liver Concentration in Sickle Cell Patients with Normal Renal and Hepatic Function and Experience with Deferoxamine Chelation Therapy in Reducing Liver Gd
- Jean-Sebastien Raynaud: What Does Gadolinium Retention (in other organs) Mean? Beyond the Quantification, Focus on the Kinetics, Forms, and Localization of the Gadolinium
Session 6 - Clinical Manifestations of Gadolinium Retention
- Paul Evans: Summary of Animal Data
- Alberto Spinazzi: Summary of Human Data
- Joel Ray: Clinical Manifestations of Fetal Exposure to GBCAs
- Richard Semelka: Clinical Outcomes of Chelation Therapy
- Anthony Fotenos: FDA Perspective
- Ali Abu-Alfa: Approach to Prove/Disprove Association of Gd Retention with Clinical Manifestations
Session 7 - Big Data/Epidemiology
- Sebastian Schneeweiss: Healthcare Data Science to Quantify Adverse Health Effects of MRI Exposure
- Mythreyi Chatfield: Is There a Role for Registry Data in This Type of Research?
- Carlo Quatrocchi: Big Data Perspective: International and European Gadolinium Retention Evaluation Consortia
- Rickey Carter: Role of Big Data Versus Other Well-designed Structured Research
- Sue-Jane Wang: The FDA and the Role of Prospective Strategies for Possible Identification of Gadolinium Retention Issues
- Tim Leiner: Application of Machine Learning to Improve Understanding of Gd-Deposition