Creating Biomedical Technologies to Improve Health

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Science Highlights • December 6, 2017
Surgical planning is critical for obtaining the best outcomes, avoiding medical errors, and limiting damage to surrounding nerves and healthy tissues. Now NIBIB-funded scientists have developed a new technique for 3D-printing patient-specific organ models – here the prostate gland -- using polymers that accurately model the prostate’s dimensions and physical properties, while also providing quantitative tactile feedback, or response to pressure, incisions, and suturing.
Science Highlights • December 4, 2017
Eleven years ago, Andrew Meas sustained a spinal cord injury as the result of a collision with an oncoming vehicle while riding his motorcycle. The injury left him paralyzed from the chest down. He enrolled in a study at the University of Louisville in which researchers would investigate whether spinal stimulation, in conjunction with daily training on a treadmill, could restore some ability to move. Meas was able to voluntarily move his legs, reach a standing position with minimal assistance, and stand without assistance during 10-second intervals on each leg and both legs at once.
Grantee News • November 30, 2017

A stem cell-derived in vitro model displays key small intestine characteristics including innate immune responses, according to a new study. Read more at Science Newsline.

Grantee News • November 30, 2017

A newly developed microscope is providing scientists with a greatly enhanced tool to study how neurological disorders such as epilepsy and Alzheimer's disease affect neuron communication. Read more from the Optical Society.

Grantee News • November 30, 2017

A novel technology enables the modeling of human liver transplantation in an experimental setting. Read more at Phys.Org.

Grantee News • November 30, 2017

A new method for delivering chemotherapy nanodrugs has been created that increases the drugs' bioavailability and reduces side-effects. Their study shows that administering an FDA-approved nutrition source prior to chemotherapy can reduce the amount of the toxic drugs that settle in the spleen, liver and kidneys. Read more from Carnegie Melon University.

NIBIB in the News • November 29, 2017

The small but growing do-it-yourself (DIY) microscopy community has flourished as researchers strive to overcome the limitations of current microscopic technology. Numerous researchers, including US National Heart, Lung, and Blood Institute cell biologist Clare Waterman, who is known for using new camera technology to develop a technique called fluorescent speckle microscopy4. Biophysicist Hari Shroff of the US National Institute of Biomedical Imaging and Bioengineering Section on High Resolution Optical Imaging has contributed to free microscope configuration resources for use by fellow scientists. Read more in Nature.

Science Highlights • November 29, 2017
Scientists are using their increasing knowledge of the complex interaction between cancer and the immune system to engineer increasingly potent anti-cancer vaccines. Now researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a synergistic nanovaccine packing DNA and RNA sequences that modulate the immune response, along with anti-tumor antigens, into one small nanoparticle. The nanovaccine produced an immune response that specifically killed tumor tissue, while simultaneously inhibiting tumor-induced immune suppression. Together this blocked lung tumor growth in a mouse model of metastatic colon cancer.
Press Releases • November 13, 2017
Hari Shroff, Ph.D., chief of the National Institute of Biomedical Imaging and Bioengineering’s lab section on High Resolution Optical Imaging (HROI), and his team have spent the last few years developing optical microscopes that produce high resolution images at very high speed. After his lab develops these new microscopes, they release the plans and software for free, so any researcher can replicate the advances made at NIH. This latest microscope builds on previous improvements that Shroff’s lab had made with selective plane illumination microscopy (SPIM).
Science Highlights • October 25, 2017
More than 50 million Americans have food allergies and often just trace amounts of allergens can trigger life-threatening reactions. Now, NIBIB-funded researchers at Harvard Medical School have developed a $40 device that fits on a key chain and can accurately test for allergens, like gluten or nuts, in a restaurant meal in less than 10 minutes.

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