Creating Biomedical Technologies to Improve Health



Grantee News • December 9, 2016

Researchers have invented a novel live-cell imaging method that could someday help biologists better understand how stem cells transform into specialized cells and how diseases like cancer spread. The Photonic Crystal Enhanced Microscope (PCEM) is capable of monitoring and quantitatively measuring cell adhesion, a critical process involved cell migration, cell differentiation, cell division, and cell death. Read more at Engineering at Illinois News.

Science Highlights • December 1, 2016
Researchers have created a microfluidic device that can produces millions of droplets containing liver microtissues and could lead to better methods for screening drugs for liver toxicity.
Science Highlights • December 1, 2016
A dime-sized patch of tiny, dissolvable microneedles could be the biomedical advance that expands the reach of vaccines to remote parts of the world, and overcomes fear that prevents many from getting a flu shot each year. Mark Prausnitz, Ph.D., Georgia Institute of Technology, presented the microneedle technology and results from his research leading up to a phase 1 clinical trial during a September 2016 seminar.
Science Highlights • December 1, 2016
Gene therapies could revolutionize medicine, including many forms of cancer treatment. For their potential to be realized, however, biomedical researchers must develop ways to prevent unintended immune responses and cell mutations. To achieve the benefits of gene therapy without negative side effects, NIBIB grantee Jordan J. Green, Ph.D., develops biodegradable nanoparticles that can be biochemically engineered to carry therapies that can seek out and kill cancer tumors.
Science Highlights • November 29, 2016
By significantly increasing the speed of functional MRI (fMRI), NIBIB-funded researchers have been able to image rapidly fluctuating brain activity during human thought. fMRI measures changes in blood oxygenation, which were previously thought to be too slow to detect the subtle neuronal activity associated with higher order brain functions. The new discovery is a significant step towards realizing a central goal of neuroscience research: mapping the brain networks responsible for human cognitive functions such as perception, attention, and awareness.
Grantee News • November 29, 2016

In the near future, hemophiliacs could be able to treat their disease by simply swallowing a capsule. Thanks to a new breakthrough, treatment for hemophilia can now be administered via a biodegradable system, a capsule, giving people affected by the hereditary bleeding disorder hope for a less expensive, less painful treatment option than conventional injections or infusions. Read more at UT News.

Grantee News • November 25, 2016

A research team has developed a first-of-its-kind soft, flexible microfluidic device that easily adheres to the skin and measures the wearer's sweat to show how his or her body is responding to exercise. Read more at Northwestern Research News.

Grantee News • November 22, 2016

Scientists report using human pluripotent stem cells to grow human intestinal tissues that have functioning nerves in a laboratory, and then using these to recreate and study a severe intestinal nerve disorder called Hirschsprung’s disease. Read more at Engadget.

Grantee News • November 17, 2016

A new biomaterial is under development that has potential to protect patients at high risk for bleeding in surgery, report researchers. Read more at BioPortfolio.

Grantee News • November 17, 2016

Imagine swallowing a pill today that continues releasing the daily dose of a medicine you need for the next week, month or even longer. Investigators have developed a long-acting drug delivery capsule that may help to do just that in the future. To test the capsule's real-world applications, the team used both mathematical modeling and animal models to investigate the effects of delivering a sustained therapeutic dose of a drug called ivermectin, which is used to treat parasitic infections. Read more at MIT News.