Creating Biomedical Technologies to Improve Health

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Science Highlights • February 13, 2017
Researchers funded by the National Institute of Biomedical Imaging and Bioengineering have developed a non-invasive imaging technique that accurately detects skin cancer without surgical biopsy. Multiphoton microscopy of mitochondria—small organelles that produce energy in cells—accurately identified melanomas and basal cell carcinomas by detecting abnormal clusters of mitochondria in both types of skin cancer.
Grantee News • February 13, 2017

Novel technology has been used to monitor vulnerabilities for cardiovascular events, aid in diagnosis and treatment. Read more at UW Today.

Grantee News • February 9, 2017

A desktop diagnosis tool has been developed that detects the presence of harmful bacteria in a blood sample in a matter of hours instead of days. The breakthrough was made possible by a combination of proprietary chemistry, innovative electrical engineering and high-end imaging and analysis techniques powered by machine learning. Read more at Phys.org.news

Science Highlights • February 9, 2017
Brain surgery for removing cancerous tissue is a delicate and high-stakes task. Now researchers funded by NIBIB have created a way to improve tumor removal surgery by distinguishing cancerous tissue from healthy tissue faster. The method developed by researchers at the University of Michigan Medical School makes brain tumor surgery more precise, improving safety.
February 7, 2017

Researchers have designed a small voltaic cell that is sustained by the acidic fluids in the stomach and generates enough power to run sensors or drug delivery devices that can reside in the gastrointestinal tract for extended periods. This type of power could offer a safer and longer-lasting alternative to the traditional batteries now used to power such devices. Read more at MIT News.

Science Highlights • February 1, 2017
Researchers at NIBIB have developed a new radiotracer to diagnose prostate cancer and conducted a successful Phase I clinical trial. Prostate cancer is the fifth leading cause of death worldwide and is especially difficult to diagnose. While prostate cancer is relatively easy to treat in its early stages, it is prone to metastasis and can quickly become deadly. In order to plan how aggressively they should treat the cancer, it is important for doctors to know how far the cancer has progressed. NIBIB researchers have attempted to solve this problem by developing a radiotracer that could identify prostate cancer at all stages.
Science Highlights • January 30, 2017
A team of scientists funded by the National Institutes of Health has developed a new tool to monitor under a microscope how cells attach to one another. Studying adhesion events can help researchers understand how tissues grow, how diseases spread, and how stem cells differentiate into more specific cell types.
Grantee News • January 25, 2017
In the three years between Brett Johnson’s brain cancer surgeries, Brigham and Women's Hospital opened the Advanced Multimodality Image Guided Operating (AMIGO) suite, designed to guide complex treatments and procedures with navigation tools and imaging technologies including MRI, CT (computed tomography), PET (positron emission tomography), fluoroscopy, angiography, and ultrasound.

Read more at Brigham Health magazine.

Science Highlights • January 25, 2017
An important step in planning tumor surgery includes assessing the tumor stiffness to aid in surgical planning. For decades, tumors near the surface of the body have been evaluated for stiffness by simple palpation—the physician pressing on the tissue. Because tumors within the skull cannot be palpated, researchers used Magnetic Resonance Elastography (MRE) to assess pituitary tumor stiffness. MRE reliably identified tumors that were soft enough for removal with a minimally-invasive suction technique versus harder tumors requiring more invasive surgery.
Grantee News • January 24, 2017

Biomedical engineers report they have worked out a noninvasive way to release and deliver concentrated amounts of a drug to the brain of rats in a temporary, localized manner using ultrasound. Read more at DotMed.com

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