Creating Biomedical Technologies to Improve Health



Grantee News • March 19, 2018

An engineering team has developed a process that combines biomaterials-based cell patterning and stem cell technology to make a 3-D tissue model that could mimic early stage human heart development. Embryotoxicity is just one potential use of the modeling platform. Read more at Science Newsline Medicine.

Grantee News • March 16, 2018

In a study conducted in rural India, researchers have found that mobile phone reminders linked with incentives such as free talk time minutes work better than phone alerts alone to improve childhood immunization rates in poor communities. Read more at Science Newsline Medicine.

Grantee News • March 16, 2018

In a step toward accelerating the production of new gene therapies, scientists report that they have developed remote-controlled, needle-like nanospears capable of piercing membrane walls and delivering DNA into selected cells. They say the new technique, which can ferry biological materials to cells with pinpoint accuracy, overcomes many of the existing barriers to effective gene modification. Read more at ACS Nano News.

Grantee News • March 8, 2018

A team led by engineers has opened a window into the cell by developing an optical tool that can read metabolism at subcellular resolution, without having to perturb cells with contrast agents, or destroy them to conduct assays. The researchers were able to use the method to identify specific metabolic signatures that could arise in diabetes, cancer, cardiovascular and neurodegenerative diseases. Read more at Science Daily.

Grantee News • March 6, 2018
When it comes to concocting the complex mix of molecules that makes up fibers of natural silk, nature beats human engineering hands down. Despite efforts to synthesize the material, artificial varieties still cannot match the natural fiber’s strength.
Grantee News • March 5, 2018

Scientists peer inside mammalian cells, producing intricately detailed, 3-D images of the tiny structures within and tracking molecules' subtle movements. Read more at Stanford News.

Grantee News • March 5, 2018
MIT team of scientists have created a hair-thin implant that can drip medications deep into the brain by remote control and with pinpoint precision.

Read more at The Seattle Times.

Science Highlights • February 26, 2018
Pharmaceuticals can target specific molecules involved in disease processes, but get distributed throughout the body where they can cause unwanted side effects. An approach known as electroceuticals aims to avoid systemic exposure by using small wires to electrically monitor individual nerves that control organ function and carry information about disease. The promise of electroceuticals has been challenging due to the lack of biocompatible wires. Now, NIBIB-funded researches have spun carbon nanotubes into flexible, nerve-sized yarns capable of long-term connections in live animals. The development of these biocompatible yarns opens the possibility of new bioelectric diagnostics and therapies through regulation of organ function at the single nerve level.
Science Highlights • February 22, 2018
When cardiovascular disease causes blocked blood vessels, tissues die because the oxygen carried by blood cells cannot reach the tissue. Surgery can remove blockages in large vessels in the heart or legs but is not possible in small vessels. To address this problem, researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) designed 3D-printed patches seeded with vessel-inducing endothelial cells in various geometric patterns. Using a mouse model of hindlimb ischemia, the researchers identified specific patch patterns that induced growth of organized, tissue-saving blood vessels, demonstrating the potential for the novel technology to address this significant public health problem.
Grantee News • February 15, 2018

Biomedical engineers are growing tracheas by coaxing cells to form three distinct tissue types after assembling them into a tube structure-without relying on scaffolding strategies currently being investigated by other groups. Read more from Case Western Reserve University Daily.