Creating Biomedical Technologies to Improve Health

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Science Highlights • February 8, 2018
Creating an artificial implantable kidney would be an epic advance in medicine and could address a chronic shortage of donor kidneys needed for transplant. Researchers have been at this quest for the past 15 years and keep coming upon one extremely knotty problem: how to keep the blood flowing smoothly through the artificial device without clotting. To surmount this problem, recipients of NIBIB Quantum Awards combined rare expertise in artificial kidney development and in computer simulation of blood flow, in a study in the Journal of Biomechanics.
Grantee News • February 7, 2018
Making the leap from research project to commercialized product is a daunting challenge. Several years ago, NIBIB-funded researchers at the University of Illinois at Urbana-Champaign launched a start-up company to help facilitate this process. Their efforts were recently recognized at the SPIE Startup Challenge during the Photonics West event held in San Francisco, CA. The device they developed—a hand-held, low-cost imaging platform for diagnosing middle ear infections—was named winner of the Challenge. Read more at optics.org
Science Highlights • February 5, 2018
Cancer fighting nanovaccines have shown significant promise, but clinical application has been hampered by complications in large-scale manufacturing, quality control, and safety. Biomedical engineers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) developed a new technology that enables nanovaccines to bind to the albumin protein naturally present in the body. The albumin protein then delivers these nanocomplexes to the lymph nodes, resulting in potent immune activation against multiple tumor types in mouse cancer models. The use of natural albumin as a universal vaccine shuttle is a significant step towards the application of cancer nanovaccine immunotherapy in humans.
Science Highlights • January 29, 2018
Researchers funded by the National Institute Biomedical Imaging and Bioengineering (NIBIB), a part of the National Institutes of Health (NIH), have developed florescent nanoparticles that light up to track the progress of breast cancer metastasis. They are currently testing the particles in mice with the hope of someday being able to use them in humans.
Science Highlights • January 19, 2018
Using an approach that combines ultrasound imaging and genetic engineering of bacterial microbes, a team from California Institute of Technology (Caltech), with funding from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), has created a powerful new system to track bacteria dispatched to deliver therapies deep inside the body.
Grantee News • January 19, 2018

Researchers have developed a material-based T-cell-expansion method using APC-mimetic biomaterial scaffolds, which helps achieve greater expansion of primary mouse and human T cells than existing methods. Read more at medGadget.

Grantee News • January 19, 2018

Engineers have created a biodegradable pressure sensor that could help doctors monitor chronic lung disease, swelling of the brain, and other medical conditions before dissolving harmlessly in a patient's body. Read more at UConn Today.

Science Highlights • January 16, 2018
Sutures and staples are the traditional methods for closing surgical incisions and wounds in emergency situations. However, these methods can be inadequate in complex surgeries and cannot make an air-tight or liquid-tight seal on a lung or artery wound or incision. Now researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have created a surgical glue that is squirted onto wounds and then sets to form an elastic air-tight or liquid-tight seal in just one minute. Successfully tested in animals, the sealant has enormous promise for life-saving use in humans.
Grantee News • January 9, 2018

Bioengineers have developed programmable adeno-associated viruses that may be used to deliver peptide drugs. Read more at ScienceNewsline.

Grantee News • January 9, 2018

A new blood stabilization method significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor cells, living cancer cells carried in the bloodstream. Read more at ScienceNewsline.

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