Creating Biomedical Technologies to Improve Health

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Grantee News • January 19, 2018

Researchers have developed a material-based T-cell-expansion method using APC-mimetic biomaterial scaffolds, which helps achieve greater expansion of primary mouse and human T cells than existing methods. Read more at medGadget.

Grantee News • January 19, 2018

Engineers have created a biodegradable pressure sensor that could help doctors monitor chronic lung disease, swelling of the brain, and other medical conditions before dissolving harmlessly in a patient's body. Read more at UConn Today.

Science Highlights • January 19, 2018
Using an approach that combines ultrasound imaging and genetic engineering of bacterial microbes, a team from California Institute of Technology (Caltech), with funding from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), has created a powerful new system to track bacteria dispatched to deliver therapies deep inside the body.
Science Highlights • January 16, 2018
Sutures and staples are the traditional methods for closing surgical incisions and wounds in emergency situations. However, these methods can be inadequate in complex surgeries and cannot make an air-tight or liquid-tight seal on a lung or artery wound or incision. Now researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have created a surgical glue that is squirted onto wounds and then sets to form an elastic air-tight or liquid-tight seal in just one minute. Successfully tested in animals, the sealant has enormous promise for life-saving use in humans.
Grantee News • January 9, 2018

Bioengineers have developed programmable adeno-associated viruses that may be used to deliver peptide drugs. Read more at ScienceNewsline.

Grantee News • January 9, 2018

A new blood stabilization method significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor cells, living cancer cells carried in the bloodstream. Read more at ScienceNewsline.

Grantee News • January 8, 2018

A new system designed to study how cavitation bubbles created by ultrasound therapy affect nearby cells shows that attaching microbeads to the cellular membrane could make techniques like sonogenetics or ultrasonic modulation safer and more effective. Read more from Duke University Pratt School of Engineering. 

Grantee News • January 8, 2018

Scientists have designed bacteria to reflect sound waves like submarines. The technology could eventually allow doctors to image therapeutic bacteria in the body using ultrasound. Read more at Caltech News.

Science Highlights • December 22, 2017
NIH researchers have devised a biochemically formulated patch of dissolvable microneedles for the treatment of type 2 diabetes. The biochemical formula of mineralized compounds in the patch responds to blood chemistry to manage glucose automatically. In a proof-of-concept study performed with mice, the researchers showed that the chemicals interact in the bloodstream to regulate blood sugar for days at a time.
Grantee News • December 20, 2017

A study activated genes in human stem cells that initiate biomineralization, a key step in bone formation, according to a science team. Scientists engineered spider web silk combined with silica to activate cell membrane protein receptor integrin. The research will help scientists model intracellular pathways that govern bone formation and efforts to cure diseases such as osteoporosis and calcific aortic valve disease. Read more from the Texas Advanced Computing Center.

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