Creating Biomedical Technologies to Improve Health

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NIBIB in the News • October 5, 2011
The tiniest structures in cells can be seen only using sophisticated instrumentation and informatics, but what biologists really need are improved fluorescent probes. Although advances in instrumentation and informatics should not be overlooked, many researchers believe that it is better-performing fluorescent labels that will allow super-resolution microscopy to continue to move forward. George Patterson, NIBIB Intramural Program, comments on fluorescent proteins. Read the full article from Nature.
NIBIB in the News • September 26, 2011
This article examines the role of nanoparticles in personalized medicine and how they are used for both therapeutics and diagnostics. In regard to the successful use of nanomaterials in personalized medicine, Dr. Xiaoyuan (Shawn) Chen, NIBIB, highlighted the importance of imaging methods to follow the release and efficacy of a drug. Read the full article from Chemical & Engineering News.
Science Highlights • July 29, 2011
One day in the near future, doctors may have an all-in-one device for quick and reliable identification of patients infected with dangerous microbe strains. This lab-on-a-chip will be able to detect even the smallest amounts of infectious particles in biological samples, food, and water.
Science Highlights • June 29, 2011
Magnetic resonance imaging (MRI) is a powerful tool for breast cancer detection. To extend MRI’s diagnostic capabilities, Stanford University researchers have developed a new coil array and image-processing technique that creates sharper MRI scans to reveal the fine structures of the breast and key features of breast lesions not currently visible.
Grantee News • June 28, 2011
Based on recent analysis of the personalized medicine market, Frost & Sullivan recognizes NIBIB grantee QuantaLife, Inc. with the 2011 North America Frost & Sullivan Award for New Product Innovation for its Droplet Digital Polymerase Chain Reaction (ddPCR) System. The QuantaLife ddPCR System introduces the next generation of PCR by providing absolute quantification of nucleic acid molecules. Read the full article from PR Newswire.
Grantee News • June 1, 2011
Computer scientists at Brown University have created software to examine neural circuitry in the human brain. The 2-D neural maps combine visual clarity with a Web-based digital map interface, and users can view 2-D maps together with 3-D images. The program aims to better understand myelinated axons, which have been linked to pathologies such as autism. Download the NIH Radio Audio Report or read the transcript
Science Highlights • May 31, 2011
Damaged cartilage heals slowly, if at all. University of Pennsylvania bioengineers are using stem cells from patients’ bone marrow encapsulated in hydrogels to make replacement cartilage tissue in the laboratory. The technology may help the millions of Americans who suffer from osteoarthritis and cartilage injury.
Press Releases • May 23, 2011
In this first-in-human study the investigators proposed to explore the possibility of humans regaining standing and stepping functions (as observed previously in animals) through a combination of epidural stimulation with motor training. In year 2 of the award, the first implanted human subject is now able to stand and move his previously paralyzed lower limbs.
Science Highlights • April 29, 2011
A new technology based on radiolytic labeling and mass spectrometry yielded the first high-resolution structural model of a potassium channel in open and closed positions. The model will improve scientists’ understanding of ion flow through potassium channels, a crucial component of heart and nerve function.
Science Highlights • March 30, 2011
Researchers at Brigham and Women’s Hospital/Harvard Medical School and MIT engineered a targeted nanoparticle platform that may improve chemotherapy effectiveness. The platform delivers higher amounts of drugs precisely where they are needed with fewer side effects.

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