Creating Biomedical Technologies to Improve Health



Press Releases • April 2, 2012
Researchers at the National Institutes of Health Clinical Center discovered a way to enhance delivery of transplant cells in rodents to a desired site by increasing presence of chemicals that attract the introduced cells. Non-destructive pulsed focused ultrasound interacts with tissue to elevate levels of naturally produced chemicals (such as cytokines, chemokines, and growth factors) on target tissues. Transplanted stem cells have receptors for these chemicals, so an increased presence attracts more of them to the desired site.
Grantee News • March 23, 2012
A four-year NIBIB-funded study of 146 patients with flu-like symptoms has validated a prototype rapid, low-cost, accurate, point-of-care device which could provide clinicians with an effective tool to quickly diagnose both seasonal and pandemic strains of influenza, and thus limit the spread of infection. Read the full article from Boston University.
Press Releases • March 6, 2012
Researchers have developed a method to label transplanted cells so they can be tracked by magnetic resonance imaging (MRI). In the future, as cell therapies become a more integral part of regenerative medicine and tumor treatment, there could be increased need to measure how many transplanted immune or stem cells reach their target.
Grantee News • March 1, 2012
With a grant from the NIBI, the team of Adam Maxwell, Charles Cain, Hitinder Gurm, and Zhen Xu at the University of Michigan are investigating the use of histotripsy (surgical technique using high intensity ultrasound for fractionation of tissues) to breakdown clots for the non-invasive treatment of deep vein thrombosis. Read the full article from Medical Design Briefs.
Science Highlights • February 29, 2012
Prostate cancer is the most common cancer and the second leading cause of cancer-related death in men. Successful treatment of prostate cancer relies in part on its early and accurate detection. Conventional prostate imaging approaches including ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) are not sensitive enough to detect very small tumors in the prostate or signs that the disease has metastasized (spread). A new class of agents known as viral nanoparticles offers the opportunity to improve detection of small lumps of cancer cells.
Grantee News • February 3, 2012
One of the fastest growing clinical applications of the powerful medical imaging modality MRI is the parallel imaging method, where multiple radio frequency (RF) receiver coils are used in simultaneous signal processing to speed up imaging.
Grantee News • January 26, 2012
NIBIB researcher Claude Lechene and colleagues report the first use of an approach called multi-isotope imaging spectrometry (MMIS) in living organisms. This technique has outstanding resolution: it provides data in the sub-micrometre range, allowing analysis of structures as small as cellular regions. Read the full article from Nature.
Science Highlights • January 15, 2012
New drugs are always tested in animals before they are tried in people. However, due to differences in the way that animals and people process drugs in the liver, animal models cannot predict dangerous drug side effects that are unique to humans. To tackle this problem, researchers at the Massachusetts Institute of Technology (MIT) engineered a new mouse model that harbors a tiny human liver. The mouse can be used to study drug safety and efficacy, drug-drug interactions, and human diseases such as hepatitis C.
Press Releases • January 11, 2012
Three new members have been appointed to the National Advisory Council for Biomedical Imaging and Bioengineering (NACBIB) of the National Institute of Biomedical Imaging and Bioengineering (NIBIB).
Science Highlights • December 30, 2011
As the world population ages, the number of people affected with Alzheimer’s disease is rising steadily. While there is yet no cure, certain drugs can slow Alzheimer’s progression, particularly if started early. University of Utah researchers are developing new brain imaging tools that may help doctors diagnose Alzheimer’s much earlier and more accurately than is possible with currently available tests.