NEWS & EVENTS
Breakthrough research in human cartilage repair by NIBIB grantees Jennifer Elisseeff, Ph.D. at Johns Hopkins University and Garry E. Gold at Stanford University may improve the treatment of cartilage defects. A pilot clinical study demonstrated the efficacy of an adhesive hydrogel biomaterial to support cartilage formation. Magnetic resonance imaging confirmed repair tissue fill, growth, and integration with surrounding cartilage.
NIBIB-funded researcher Stan Opella, Ph.D, has developed a new technique for determining the structure of G-Protein coupled receptors (GPCRs,) one which does not require the massive physiological modifications demanded from the current technology, X-ray crystallography. Read a related article from the NIBIB: Understanding Critical Protein Structures May Speed Drug Development.
Researchers at Duke University have developed a new ultrasound imaging technique that non-invasively detects tumors and fibrosis in the liver, thus avoiding the pain and complications associated with biopsy. These researchers are also extending the technique to aid in diagnosing other diseases, as well.
The New York Times features NIBIB grantees Bob Langer and Ralph Weissleder as being “on the front lines of turning discoveries made in the lab into a range of drugs and drug deliver systems. Without this kind of technology transfer, the thinking goes, scientific discoveries might well sit on the shelf, stifling innovation.” Read the full article from The New York Times.
NIBIB-funded research has resulted in a new spectrum of voltage-sensitive dyes (VSDs) that improves optical imaging of brain and heart electrical activity. Fluorinated hemicyanine dyes provide spectral compatibility with newly available optical technologies, offering better photostability and improving the signal to noise ratio (S:N) of the optically recorded voltage activity in cells, tissues, and organs. Read the full article from Proceedings of the National Academy of Sciences.