Creating Biomedical Technologies to Improve Health


Science Highlight: May 24, 2016

New MRI coils aim to improve patient comfort and decrease scan time

NIH-funded researchers find low-cost way to speed up MRI scans and improve resolution

New, screen-printed, flexible MRI coils may be able to reduce the amount of time it takes to get an MRI scan. Researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the National Institutes of Health (NIH), have developed light and flexible MRI coils that produce high quality MRI images and in the future could lead to shorter MRI scan time periods.

MRI scans can reveal life-saving information about patients that other types of scans such as CT or PET cannot. However, the opening of the machine is small and can be uncomfortable even for patients who don’t suffer from claustrophobia. In addition, the machine makes loud noises for long periods of time during the scan as the images are being generated. But the chief difficulty is that MRI machines can take a long time, sometimes more than an hour, to produce the images needed by the doctor, and patients must stay perfectly still in the machine the entire time. These issues can make it difficult  for many patients, but it is especially challenging with pediatric patients. To help immobilize infants, doctors will often use anesthesia, which is an added risk for this fragile patient population.

The most common MRI strengths are 1.5T and 3T.  The “T” stands for Tesla--the unit of measurement for the strength of the magnetic field.  The higher the number, the stronger the magnet. Some research labs have 7T MRI machines, but they are not yet commonly available to patients.

MRI scans take so long because they have a very low sensitivity. In some challenging pediatric cases where the patient is moving, the images may be degraded with artifacts—leading to useless data that can get in the way of a clear picture. The problem is that the main magnetic field has a big job to do. It needs to manipulate protons found in the water of the human body and it is difficult to affect enough of them simultaneously so the resulting picture is clear. One way to get clearer pictures would be to use a stronger magnet—and some new MRI machines do exactly this; but MRI machines are expensive –costing anywhere from $300,000 to a million dollars—which can strain a hospital’s budget.

Another way to increase the sensitivity of MRIs is to use high-density MRI coils arrays . These can be used to increase the strength of the received MRI signal as well as accelerate the acquisition of the signal, in order to get clearer and higher quality images. But, current receiver coils are often anatomically unmatched for the human body; they are heavy, inflexible, restrictive, and are uncomfortable for many patients.

To solve all these problems, Michael Lustig, Ph.D., and Ana Arias, Ph.D., both Associate Professors in the Department of Electrical Engineering and Computer Sciences at the University of California, Berkeley, and their team have developed new flexible MRI radiofrequency coils. The coils can be individually crafted with a screen-printer to fit patients of various sizes, such as infants or toddlers, or custom made for individual patients if needed. Screen-printing is the technology used for printing designs on T-shirts.  Because these coils are light and flexible, they can be wrapped snugly around the patient’s body that increases the sensitivity of the exam and provides clearer pictures.

Two MRI images, one clearly better in quality, with drawings of coils and their placement.

The MRI image on the left shows what the MRI scan can reveal when coil is only slightly removed from the patient. The image on the right shows the drastically increased quality when the coil is placed against the patient.










The coils are designed to work with the MRI machines that most hospitals already have (1.5 Tesla and 3 Tesla), and can be reused rather than having to be printed specifically for each patient. Arias, Lustig and their team developed a prototype of a blanket with the coils inside that can be wrapped around an infant. With printing technologies becoming more commonplace, this new design could, in the near future, be made practical for mass manufacturing and provide a low-cost way to help doctors get the information they need with the least amount of patient discomfort.. To achieve this, the team has joined forces with pediatric radiologist Shreyas Vasanawala at Lucile Packard Children’s Hospital, and GE healthcare to translate this technology to clinical practice.

A photo of the flexible MRI coil, a photo of the coil wrapped around a doll, and a drawing showing the coils in a blanket and hat wrapped around a baby.

The 3D printed coils can be bent and are easily wrapped around an infant.







“This technology could greatly increase patient comfort at a relatively low cost,” said Guoying Liu, Director of the program for Magnetic Resonance Imaging and Spectroscopy at NIBIB.  “Not having to experience the trauma of long MRI exams is a significant benefit to pediatric patients and their parents during what is often a trying time. This new development is an excellent example of how new technologies can come together to create a better experience for the patient.”

Click here to read the paper

Corea, J. R. et al. Screen-printed flexible magnetic resonance imaging receive coils. Nat. Commun. 7:10839 doi: 10.1038/ncomms10839 (2016).

This work was supported by the National Institute of Biomedical Imaging and Bioengineering through grant #R21 EB015628 and R01 EB019241.

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