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Grantee News • June 16, 2017

Many studies have shown that stiffness of the extracellular matrix, the fibrous network of collagen that surrounds cells, promotes cellular mobility; cells can get a better grip on stiffer surfaces and thus invade neighboring tissue. New research by scientists in the University of Pennsylvania School of Engineering and Applied Science is diving deeper into this relationship, showing that stiffness is not the only factor researchers should consider when studying this process. Read more at Penn News.

Grantee News • June 15, 2017

Researchers have developed a new surgical tool that uses low-frequency intravascular ultrasound to break down blood clots that cause deep vein thrombosis. The tool is the first ultrasound 'drill' that can be aimed straight ahead, allowing doctors to better target clots -- which holds promise for significantly reducing treatment time. To date, the technology has been tested only in synthetic blood vessels. Read more at NC State News.

Grantee News • June 15, 2017

A research team is pioneering an infused 3-D-printed patch that guides the growth of new blood vessels, avoiding some of the problems with other approaches to treating ischemia. Read more at BU College of Engineering.

Science Highlights • June 5, 2017
Fluorescent quantum dots are valuable tools used to tag and image biological processes in live animals. However, precise fluorescent imaging at the cellular and molecular levels has not been possible because of non-specific fluorescence and light scattering by surrounding tissues. Now researchers have resolved many of these problems by using SWIR quantum dots in live mice to image working organs, take metabolic measurements, and track microvascular blood flow in normal brain and brain tumors.
Grantee News • May 31, 2017

A mechanism that controls the formation and function of plate-like nanocrystals that play a critical role in bone composition has now been discovered by researchers. Read more at University of Arkansas News.

Science Highlights • May 15, 2017
Researchers funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a new tool for detecting early pancreatic cancer. The tool uses light-scattering spectroscopy (LSS), bouncing light off targeted tissue to detect structural changes in tissue. The researchers performed a series of pilot studies using LSS and accurately distinguished benign cysts, cancerous cysts, and those with malignancy potential 95 percent of the time. The Harvard University team reported their results in the March 13, 2017, issue of Nature Biomedical Engineering.
Grantee News • May 11, 2017

Engineering researchers have developed a revolutionary process for 3D printing stretchable electronic sensory devices that could give robots the ability to feel their environment. The discovery is also a major step forward in printing electronics on real human skin. Read more at University of Minnesota News.

Grantee News • May 11, 2017

Biomedical engineers are now able to take a live, holistic look at the inner workings of a small animal with enough resolution to see active organs, flowing blood, circulating melanoma cells and firing neural networks. The technique uses the best of both light and ultrasound, breaking long-standing resolution and speed barriers in small-animal whole-body imaging, providing full cross-sectional view of a small animal's internal functions in real-time. Read more at Duke Pratt School of Engineering News.

Science Highlights • May 10, 2017
A research team funded by the National Institute of Biomedical Imaging and Bioengineering has engineered a small peptide that binds to a protein found in high-risk prostate cancers. By linking the peptide to a clinically used MRI contrast agent, the group used MRI to identify aggressive, metastatic tumors in mouse models of prostate cancer. The system is a promising step for reliable early detection and treatment of high-risk, life-threatening prostate cancer.
Grantee News • May 2, 2017

Studies have suggested a link between fitness and memory, but researchers have struggled to find the mechanism that links them. A new study found that the key may lie in the microstructure of the hippocampus, a region in the middle of the brain involved in memory processes. Read more at Illinois Research News.

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