Explore more about: Biomaterial Interfaces

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NIBIB-funded researchers have created nanoparticles for successful gene therapy of a mouse model of macular degeneration. The nanoparticle carriers have the potential to significantly expand the effectiveness of gene therapies for human eye diseases, including blindness.
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Using DNA origami as a virus-like scaffold, researchers designed an HIV-like particle that provokes a strong response from human immune cells grown in the lab. They are now testing this approach as a potential vaccine candidate in live animals, and adapting it to SARS-CoV-2, as well as other pathogens.
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With the help of photolithography and programmable DNA, researchers have created a new technique that can rapidly 'print' two-dimensional arrays of cells and proteins that mimic a wide variety of cellular environments in the body. This technique could help scientists develop a better understanding of the complex cell-to-cell messaging that dictates a cell's final fate.
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Biological engineers have created a multitissue model that lets them study the relationships between different organs and the immune system on a microfluidic chip seeded with human cells. With this 'organs-on-a-chip' model, they could explore the role of immune cells in ulcerative colitis and other inflammatory diseases.
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A new synthetic biology toolkit developed at Northwestern Engineering will help researchers design mammalian cells with new functionalities. The toolkit, called the Composable Mammalian Elements of Transcription (COMET), could result in new therapies for difficult-to-treat diseases, like cancer.
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After a patient swallows anordinary-looking capsule, the star’s six arms unfold inside the stomach and steadily release ingredients for a week; then the arms break off and leave the body like undigested food. The pill can deliver a variety of prescription medicines.
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Promising intracellular protein-based therapeutics have been of limited use due to the difficulty of delivery into diseased cells. Now bioengineers have developed nanoparticles that can deliver these therapeutics to their targets—avoiding degradation and toxic interactions with healthy tissues.
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Millions of people are treated with antibiotics each year for infections or as a preventative measure. Two teams of NIBIB-funded scientists have been working to find alternative solutions for treating bacterial infections, especially antibiotic-resistant bacteria.
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Low-frequency electric stimulation shows promise as a possible alternative to medications for restoring hair growth in people whose hair has begun to thin.
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The novel approach better mimics the tumor environment in patients. Made with extracellular matrix (ECM) from pig brains and seeded with tumors from patients, the system is revealing tumor/ECM interactions that aid tumor growth, providing potential targets for new therapies.