Biomechanical Engineering

This program supports the design, development, and demonstration of biomechanical technologies for biomedical intervention.


This program focuses on engineering new biomechanical materials, sensors, actuators, and other parts and modules to interface and communicate with human biology and engineered systems for biomedical intervention. These parts and modules act as biotransducers to convert mechanical energy to biological action. Projects should be directed toward overcoming a technological challenge that limits biomedical adoption. This program encourages projects that use a design-build-test approach.

Examples of biomechanical parts and modules include but are not limited to:

  • mechano-sensitive scaffolds for modulating tissue
  • microgrippers and drills for surgical robots
  • 3D printed tactile sensors for prosthetics
  • soft elastomeric actuators for assistive devices

Additional Emphasis

Furthermore, this program focuses on the development of mathematical and computational methods, the development of screening and processing tools, and the discovery of design principles as key components in the design, build, and test methodology to engineer relevant biomechanical modules.


The development of integrated systems is supported by the Bionic Systems, Robotic Systems, Synthetic Biological Systems, and Adaptive Biomaterial Systems programs.

Grant Number Project Title Principal Investigator Institution
1-DP2-EB024246-01 Origins of human blood lineages in regenerative medicine Sean Bendall Stanford University
1-R15-EB026196-01 Characterization of Ventricular Catheter Performance for Improved Treatment of Pediatric Hydrocephalus Stephanie Termaath University of Tennessee Knoxville
5-R01-EB023880-03 Multicomponent solutions for the preservation of cell therapy products Allison Hubel University of Minnesota
5-R03-EB026526-02 Hybrid decellularized extracellular matrix hydrogel for harnessing mesenchymal stem cell pro-angiogenic potential Gargi Ghosh University of Michigan at Ann Arbor
5-R21-EB026175-02 Developing Hybrids of Cardiac Tissue and Biodegradable Electronics Towards Heart Implants with On-line Monitoring and Stimulating Functions Cunjiang Yu University of Houston
5-R03-EB024134-02 Controlling matrix metalloproteinase activity for engineered tendon formation Nathan Schiele University of Idaho
5-R01-EB022033-04 Engineering an immuno-isolating hydrogel for restoring ovarian endocrine function Ariella Shikanov University of Michigan at Ann Arbor
5-R01-EB024531-03 Computational Design, Fabrication, and Evaluation of Optimized Patient-Specific Transtibial Prosthetic Sockets Hugh Herr Massachusetts Institute of Technology
5-R01-EB021926-04 Polymerized Hemoglobins for Facilitated Oxygen Transport in Hepatic Bioreactors Andre Palmer Ohio State University
5-R03-EB025873-02 Hybrid 3D bioprinting of bone using microRNA-based bioink Brad Amendt University of Iowa