Discovery Engineering and Applied Science

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This Biological Engineering program supports cross-cutting science and engineering projects that advance the development of broadly applicable biomedical technologies based on biomaterials and engineered biology that directly interface with, monitor, and regulate biological processes and functions of human physiology to enable new paradigms of human health

Emphasis

The development of biomedical technologies and models and methods (i.e., engineering tools and approaches to accelerate the development of biomaterials-based and biology-based technologies) are multi-disciplinary by nature. This program encompasses a variety of projects that involve many facets of discovery engineering and/or applied science.

Projects might focus on:

  • elucidating important engineering design rules or key foundational principles underlying future engineering
  • redesigning or prototyping platform technologies
  • characterizing (in vitro, ex vivo, or in vivo) broadly applicable technologies and prototypes

Major Programmatic Interests

Biointerfacial Technologies – technologies that operate at the interface of abiotic materials and biological systems

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Biomimetic Technologies – technologies that recapitulate life/living processes found in biological systems

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Biomolecular Technologies – technologies based on subcellular components

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Cellular Technologies – technologies based on single cell systems

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Cellular and Subcellular Technologies

Multicellular Technologies – technologies based on systems of interacting cells

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Nanotechnologies – technologies that operate at the nano-scale

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    Related News

    May 16, 2023
    NIH researchers found that a gel made from the seeds of a South American palm tree entraps SARS-CoV-2 and the protein the virus uses to enter cells, preventing the virus from infecting cells in laboratory cultures. Their study is in Scientific Reports. Source: Eunice Kennedy Shriver National Institute of Child Health and Human Development.
    May 11, 2023
    A schematic shows a skin microtissue model being struck by a laser beam to simulate a burn wound.
    Tissue engineering research has uncovered that a skin cell type could be a new therapeutic target to accelerate the healing of burns and possibly other wounds.
    May 8, 2023
    Automation uncovers combinations of amino acids that feed two bacterial species and could tell us much more about the 90% of bacteria that humans have hardly studied. An artificial intelligence system enables robots to conduct autonomous scientific experiments -- as many as 10,000 per day -- potentially driving a drastic leap forward in the pace of discovery in areas from medicine to agriculture to environmental science. Source: University of Michigan/Science Daily
    March 31, 2023
    Artistic representation of a lipid nanoparticle containing mRNA
    Researchers at Carnegie Mellon University are developing lipid nanoparticles that are designed to carry mRNA specifically to the pancreas. Their study in mice could pave the way for novel therapies for intractable pancreatic diseases, such as diabetes and cancer.
    March 15, 2023
    Researchers create a biomimetic model to study wound healing in burn and laceration wounds. The team designed an in vitro model system made of fibroblasts embedded in a collagen hydrogel. Wounds were created in this microtissue using a microdissection knife to mimic laceration or a high-energy laser to simulate a burn. They discovered that fibroblasts clear away damaged tissue before depositing new material. This part of the healing process is slower in burn wounds. Source: American Institute of Physics/Science Daily