Delivery Systems and Devices for Drugs and Biologics

The area of delivery systems and devices for drugs and biologics includes the delivery of nucleic acids, peptides, proteins, vaccines, genes, small molecules, and theranostics. Emphasis is on the engineering of new delivery vehicles that may include (but are not limited to) novel biomaterials, liposomes, micelles, nanoparticles, and dendrimers; or various delivery modalities that may include, for example, ultrasound, electroporation, implantable pumps, or stimulators. The scope of work may include, for example, development of the delivery vehicle or device itself, and proof of concept testing through preliminary in vitro and in vivo studies.

Grant Number Project Title Principal Investigator Institution
5-R21-EB025490-02 Harnessing the gap junction network for direct intracellular delivery of siRNA and chemotherapeutics Jeanne Stachowiak University of Texas, Austin
5-R01-EB020676-04 Trehalose Glycopolymers to Enhance both Pharmacokinetics and Stability of Therapeutic Proteins Heather Maynard University of California Los Angeles
5-R03-EB026189-02 Interfacially-stabilized polymeric nanosystems for drug delivery Marc Ilies Temple Univ of The Commonwealth
5-R01-EB022040-04 The alternative complement pathway and hemocompatibility of nanosurfaces Dimitri Simberg University of Colorado Denver
5-R01-EB022641-03 Supramolecular Bioorthogonal Nanozymes for Targeted Activation of Therapeutics Vincent Rotello University of Massachusetts Amherst
5-R01-EB025651-02 Targeting through Selective Cell Labeling Jianjun Cheng University of Illinois at Urbana-Champaign
5-R21-EB026590-02 In situ Enzymatic Synthesis of Aptamer Targeted Polynucleotide Drug Nanoparticles for Cancer Therapy Stefan Zauscher Duke University
1-R21-EB028108-01 Suppressing Radiotherapy-Induced Metastasis in Aggressive Breast Cancers via 'On-Demand' siRNA Delivery from Responsive Polymer Nanoparticles Millicent Sullivan University of Delaware
1-R21-EB026723-01A1 A novel drug loading method to protect neural cells from oxidative stress induced by a hypoxic/ischemic inflammatory environment Kyle Lampe University of Virginia
1-R21-EB027843-01 Zwitterionic Polypeptide-protein Conjugation for the Safe and Efficient Delivery of Therapeutic Enzymes Shaoyi Jiang University of Washington