Delivery Systems and Devices for Drugs and Biologics

The area of delivery systems and devices for drugs and biologics includes the delivery of nucleic acids, peptides, proteins, vaccines, genes, small molecules, and theranostics. Emphasis is on the engineering of new delivery vehicles that may include (but are not limited to) novel biomaterials, liposomes, micelles, nanoparticles, and dendrimers; or various delivery modalities that may include, for example, ultrasound, electroporation, implantable pumps, or stimulators. The scope of work may include, for example, development of the delivery vehicle or device itself, and proof of concept testing through preliminary in vitro and in vivo studies.

Grant Number Project Title Principal Investigator Institution
5-R21-EB025490-02 Harnessing the gap junction network for direct intracellular delivery of siRNA and chemotherapeutics Jeanne Stachowiak University of Texas, Austin
5-R01-EB000487-25 Cellular and molecular transport in mucus W. Saltzman Yale University
5-R21-EB026008-02 Structured DNA Nanoparticles Therapeutic mRNA and CRISPR/Cas9 Delivery Mark Bathe Massachusetts Institute of Technology
7-R01-EB017722-05 Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma Yolonda Colson Massachusetts General Hospital
1-R21-EB026560-01A1 Aptamer-Modified POSH Inhibitor Micelles as a Novel Leukemia Treatment Modality Bret Ulery University of Missouri-Columbia
5-R01-EB020676-04 Trehalose Glycopolymers to Enhance both Pharmacokinetics and Stability of Therapeutic Proteins Heather Maynard University of California Los Angeles
5-R01-EB022040-04 The alternative complement pathway and hemocompatibility of nanosurfaces Dimitri Simberg University of Colorado Denver
5-R21-EB026723-02 A novel drug loading method to protect neural cells from oxidative stress induced by a hypoxic/ischemic inflammatory environment Kyle Lampe University of Virginia
5-R21-EB028108-02 Suppressing Radiotherapy-Induced Metastasis in Aggressive Breast Cancers via 'On-Demand' siRNA Delivery from Responsive Polymer Nanoparticles Millicent Sullivan University of Delaware
7-R01-EB019893-04 Cancer Stem Cell-Targeted, Silicate Prodrug Nanoparticles to Combat Recurrence Jayanth Panyam Temple Univ of The Commonwealth