Delivery Systems and Devices for Drugs and Biologics

The area of delivery systems and devices for drugs and biologics includes the delivery of nucleic acids, peptides, proteins, vaccines, genes, small molecules, and theranostics. Emphasis is on the engineering of new delivery vehicles that may include (but are not limited to) novel biomaterials, liposomes, micelles, nanoparticles, and dendrimers; or various delivery modalities that may include, for example, ultrasound, electroporation, implantable pumps, or stimulators. The scope of work may include, for example, development of the delivery vehicle or device itself, and proof of concept testing through preliminary in vitro and in vivo studies.

Grant Number Project Title Principal Investigator Institution
5-R21-EB025490-02 Harnessing the gap junction network for direct intracellular delivery of siRNA and chemotherapeutics Jeanne Stachowiak University of Texas, Austin
5-R01-EB000487-25 Cellular and molecular transport in mucus W. Saltzman Yale University
5-R21-EB026008-02 Structured DNA Nanoparticles Therapeutic mRNA and CRISPR/Cas9 Delivery Mark Bathe Massachusetts Institute of Technology
7-R01-EB019893-04 Cancer Stem Cell-Targeted, Silicate Prodrug Nanoparticles to Combat Recurrence Jayanth Panyam Temple Univ of The Commonwealth
5-R21-EB028108-02 Suppressing Radiotherapy-Induced Metastasis in Aggressive Breast Cancers via 'On-Demand' siRNA Delivery from Responsive Polymer Nanoparticles Millicent Sullivan University of Delaware
5-R03-EB027910-02 Evaluation of Co-Delivery and Therapeutic Efficacy of siRNA and miRNA to Prostate Cancer by Nucleic Acid Nanovehicles Emil Khisamutdinov Ball State University
5-R01-EB017270-07 Chemophototherapy with Porphyrin-phospholipid Liposomes Permeabilized by Red Light Jonathan Lovell State University of New York at Buffalo
5-R21-EB026564-02 Genetic engineering RGD-containing siRNA protein carrier Hong Yan Liu Dotquant, Llc
5-R21-EB026560-02 Aptamer-Modified POSH Inhibitor Micelles as a Novel Leukemia Treatment Modality Bret Ulery University of Missouri-Columbia
7-R01-EB017722-05 Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma Yolonda Colson Massachusetts General Hospital