Explore more about: Engineered Cells

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What if bacteria—which love to grow deep inside tumors—could guide cancer therapies directly to their target? NIH-funded researchers have engineered a bacterial strain to “light up” tumors so that reprogrammed T cells, drawn like a moth to a flame, can find and destroy them. Their preclinical treatment could potentially be effective against any solid tumor type.
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Researchers at Ohio State University have developed nanocarriers derived from mice skin cells that reduced lung inflammation in mice. Further research could lead to a treatment for acute respiratory distress syndrome and other conditions.
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Bioengineers from Columbia University are developing a pipeline to systematically evaluate how bacterial treatments might synergize with existing anti-cancer therapies in preclinical models.
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In a new study published in Science Translational Medicine, researchers demonstrated that human kidney organoids are useful models to identify the point of permanent and reversible kidney cell damage and they also discovered a drug candidate that could potentially prevent chronic disease before reaching that point. Read more at STAT.
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NIBIB-funded researchers have found a way to model the human neuromuscular junction by growing these synapses in a lab, which could accelerate novel treatments for neuromuscular diseases.
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Medical science is a key step closer to the cryopreservation of brain slices used in neurological research, pancreatic cells for the treatment of diabetes and even whole organs thanks to a new computer model that predicts how tissue’s size will change during the preservation process.
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A University of Arkansas professor has received a four-year, $1.6 million grant from the National Institutes of Health to develop non-invasive, real-time “optical biopsies” of chronic skin wounds.
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The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy. Called Type 1 diabetes, this disorder can occur at any age and can be fatal if not carefully managed with insulin shots or an insulin pump to balance the body's sugar levels.
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A change of instructions in a computer program directs the computer to execute a different command. Similarly, synthetic biologists are learning the rules for how to direct the activities of human cells.
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Sickle cell disease leads to chronic pain, organ failure, and early death in patients worldwide. A team has demonstrated a gene editing approach that efficiently corrects the mutation underlying SCD in patient blood stem cells and in mice. This treatment rescued disease symptoms in animal models, enabling long-lasting production of healthy blood cells, and could inspire a therapeutic strategy for SCD.