Vascular and interventional radiologists report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab. This discovery could solve a problem that has long plagued drug delivery to tumors.
Explore more about: Drug Delivery Systems
February 16, 2021
January 7, 2021
Researchers have successfully used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a rare genetic disease that causes extreme premature aging in children and can significantly shorten their life expectancy.
September 28, 2020
NIBIB-funded researchers have created nanoparticles for successful gene therapy of a mouse model of macular degeneration. The nanoparticle carriers have the potential to significantly expand the effectiveness of gene therapies for human eye diseases, including blindness.
June 30, 2020
Using DNA origami as a virus-like scaffold, researchers designed an HIV-like particle that provokes a strong response from human immune cells grown in the lab. They are now testing this approach as a potential vaccine candidate in live animals, and adapting it to SARS-CoV-2, as well as other pathogens.
February 11, 2020
A new synthetic biology toolkit developed at Northwestern Engineering will help researchers design mammalian cells with new functionalities. The toolkit, called the Composable Mammalian Elements of Transcription (COMET), could result in new therapies for difficult-to-treat diseases, like cancer.
January 27, 2020
After a patient swallows anordinary-looking capsule, the star’s six arms unfold inside the stomach and steadily release ingredients for a week; then the arms break off and leave the body like undigested food. The pill can deliver a variety of prescription medicines.
April 3, 2020
Promising intracellular protein-based therapeutics have been of limited use due to the difficulty of delivery into diseased cells. Now bioengineers have developed nanoparticles that can deliver these therapeutics to their targets—avoiding degradation and toxic interactions with healthy tissues.
December 9, 2019
Scientists report they have created a tiny, nanosize container that can slip inside cells and deliver protein-based medicines and gene therapies of any size -- even hefty ones attached to the gene-editing tool called CRISPR.
October 9, 2019
MIT engineers designed a drug capsule that can carry insulin or other protein drugs and protect them from the harsh environment of the gastrointestinal tract. When the capsule reaches the small intestine, it breaks down to reveal dissolvable microneedles that attach to the intestinal wall and release drug for uptake into the bloodstream.
November 25, 2019
NIBIB-funded biomedical engineers at the Ohio State University (OSU) have demonstrated a new method for delivering an anti-cancer drug in a study that tested the effect in animal models.