Creating Biomedical Technologies to Improve Health

2017 BESIP Project

Nanoinstrumentation and Force Spectroscopy Section, Laboratory of Cellular Imaging and Macromolecular Biophysics
NIBIB
Mentor Name: 
Albert Jin, Ph.D.
Mentor Email: 
Mentor Telephone: 
(301) 435-4612
Laboratory of Malaria Immunology and Vaccinology
NIAID
Mentor Name: 
David Narum, Ph.D.
Mentor Email: 
Mentor Telephone: 
(301) 435-2185

Laboratory and Project Description

This project is an ongoing collaboration among Dr. David Narum in NIAID, Dr. Albert Jin in NIBIB, and coworkers in the area of malaria vaccine development. The BESIP student shall join the ongoing investigation of the macromolecular structure and nanomechanical properties of several malaria vaccine candidates and nano-particle carriers via biological atomic force microscopy (Bio-AFM) and related bioanalysis. These protein antigens and nano-carriers are being produced via recombinant-protein biotechnology, purified, and characterized in a manner suitable for human trials and scale-up productions. We here focus on using Bio-AFM to understand the structural properties of these developing vaccines toward enhanced immunological response and eventual eradication of malaria. This project also aims to extend the AFM methodology for imaging and force spectroscopy of all macromolecules and nanostructures. Specific details of the student's work are to be determined through discussions with the mentors.