NEWS & EVENTS
NIBIB-funded scientists joined with nearly 300 international researchers to identify gene variants that determine genetic processes and may underlie neuropsychiatric diseases. The study combined the analysis of genetic data from over 190 institutes with MRI scans from more than 30,000 individuals. Read more at MedicalXpress news.
NIBIB-funded researchers have partnered with a collaborative group to develop a new generation of anti-viral treatments. The group reports the development of a compound that drives HIV to lethal mutagenesis. The strategy takes advantage of HIV's already high mutation rate by forcing it above an intolerable threshold where the virus acquires so many mutations that it breaks down and can no longer replicate. Read more at UChicago News.
Because the spine's repeating elements look alike, despite careful planning, surgeons can mistakenly operate on the wrong vertebra. Now, NIBIB-funded scientists have developed a software program that clearly labels each vertebra in an X-ray image taken just before a patient's spinal surgery. Results from the first clinical testing of the program showed that the LevelCheck software achieved 100 percent accuracy. Read more in Science Daily.
NIBIB-funded researchers have designed a nanoparticle-based gene delivery system and used it to treat brain tumors in rats. The nanoparticles are filled with genes for an enzyme that turns a compound into a potent killer of the cancer cells. Delivery of the nanoparticles to brain tumors effectively killed the deadly brain gliomas and significantly extended the lives of the treated animals. Read more at Johns Hopkins Medicine News.
NIBIB-funded researchers have developed a highly effective sensor system to improve the quality of clinical breast examinations by physicians. The training system addresses a critical need for physicians to develop the technique and skill necessary to consistently detect the presence of breast lesions during a clinical breast exam (CBE). To improve training, the device incorporates a sensor that indicates when a physician is palpating (pressing) with adequate force necessary to detect a lump in the breast.
NIBIB-funded researchers and their collaborators have used magnetic resonance imaging to show age-dependent breakdown of the human blood brain barrier (BBB). The study suggests that BBB breakdown is an early event in the aging human brain that begins in the hippocampus, a region critical for learning and memory that is affected early in Alzheimer's Disease. Watch the video of the research team describing their work.
NIBIB-funded bioengineers have teamed with their colleagues at the Wyss Institute for Biologically Inspired Engineering at Harvard University to develop a novel approach for disease diagnosis. The collaboration produced a diagnostic device composed of a small slip of paper with an array of RNA-activated sensors capable of identifying pathogens such as antibiotic-resistant bacteria and strain-specific Ebola virus. Read more and watch videos about the project at the Wyss Institute website.
A new light-based imaging method developed by NIBIB grantee Lihong Wang, Ph.D. and his team at Washington University in St. Louis enables researchers to see blood flow, blood oxygenation, and oxygen metabolism inside a living mouse brain at faster rates than ever before. Read more at news.wustl.edu.