Careers

Field: Immunology, Epigenetics, Regenerative Medicine, Trauma Medicine

Research Project Title: Genetic Understanding and Manipulation of Immune Responses to Biomaterials

Position Description: The National Institute of Biomedical Imaging and Bioengineering (NIBIB) is seeking candidates for a Post-Doctoral Fellow position in the Intramural Research Program, in the Section on Immuno-Engineering.

This position will work at the intersection of immunology and engineering to analyze biological responses to medical device implantation and develop new technologies to promote device integration and tissue regeneration. Work will focus on characterizing immune responses to materials with the opportunity to work with next-generation high-color flow cytometers and the vast microscopy knowledge available at NIBIB.  Will also work closely with collaborating immunologists in other NIH institutes and with muscle trauma researchers at Walter Reed National Military Medical Center, who will help with functional regeneration testing. The Section on Immuno-Engineering focuses on immune reactions to medical devices and regenerative therapeutics to determine biologic mechanisms of immune responses to biomaterials in order to   then leverage/modulate those to promote device integration and tissue regeneration. Candidates would be responsible for conducting studies to understand the basic molecular mechanisms of the local and systemic immune response to biomaterials and medical devices, focusing on innate immune activation and differentiation.

Qualifications: The applicant must have a Ph.D. in Molecular Biology, Immunology, or related discipline. The applicant must display strong technical experience with bisulfite sequencing and/or ChIP-sequencing, along with exposure standard techniques such as qRT-PCR and flow cytometry. Experience with animal modeling is preferred. Due to the interdisciplinary nature of the research, any interested applicants should be open to learning new techniques, especially in the field of trauma medicine and biomaterial therapeutics.

To Apply: Interested applicants should send their CV along with a one-page research statement (past/current/future) and the names and email addresses of 3 references to Dr. Kaitlyn Sadtler at kaitlyn.sadtler@nih.gov.

Position includes salary and benefits in line with NIH standard levels for postdoctoral fellows.

The NIH is dedicated to building a diverse community in its training and employment programs. The United States Government does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy and gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service, or other non-merit factor.

CONTACT: Dr. Kaitlyn Sadtler, PhD

Job Opportunities for experienced data and computer scientists are now available

The NIH Office of Data Science Strategy at the NIH has several new opportunities for experienced data and computer scientists and engineers to tackle challenging biomedical data problems with the potential for substantial public health impact. Three of these positions are of particular interest to the NIBIB community:

• Accelerating Clinical Adoption of Machine Intelligence (MI) Applications in Medical Imaging
• Expanding Theories of Brain Circuits Using Knowledge Integration
• Harnessing Data Science for Health Discovery and Innovation in Africa

Deadline: Applications are due April 30, 2020. To learn more, visit the program website.

How to apply: Submit CV and cover letter including vision statement and projects of interest. 

Eligibility: Doctoral degree (required) and industry experience (strongly preferred). Women and individuals from underrepresented groups are encouraged to apply. 

Field: Fluorescence microscopy

Position description: The Section on Biophotonics within the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH) is seeking a post-doctoral fellow with experience in fluorescence microscopy. The lab develops probes and techniques for use in diffraction-limited and super-resolution fluorescence imaging of cells and tissues. The team improves upon and exploits existing developments in fluorescent proteins, instrumentation/methodology, and image analysis to better serve the cell and developmental biology communities. Current approaches take advantage of the photophysical behavior of fluorescent probes to improve the information content of the data being collected. For example, recent and ongoing studies take advantage of the behaviors of photoswitchable fluorescent proteins as they transition between their “off” and “on” states to monitor Förster resonance energy transfer (FRET) in living cells1,2. Ongoing multiplexing developments of these approaches are designed to better facilitate multiple FRET readouts within the same cell. The team has exciting collaborative efforts underway to image protein-protein interactions at key points in the secretory pathway in addition to efforts to improve upon and utilize fluorescent protein-based biosensors using these photoswitching approaches. A successful candidate will possess the creativity, motivation, and experience to help drive these developments.

1. Ojha, N., Rainey, K.R., and Patterson G.H.  Imaging of fluorescence anisotropy during photoswitching provides a simple readout for protein self-association. Nat Commun. 2020 Jan 7;11(1):21. PMID: 31911590

2. Rainey, K.R. and Patterson G.H.  Photoswitching FRET to monitor protein-protein interactions. Proc Natl Acad Sci U S A.  2019. 116(3):864-873. PMID: 30598438

Qualifications: The applicant should have a Ph.D. in cell biology, biophysics, biochemistry, bioengineering, or related discipline. A successful candidate will have experience with one or more modes of fluorescence imaging, fluorescence image analyses, standard molecular biology techniques, and common cell culture techniques. Experience with programming is not required but is considered beneficial.

To Apply: Candidates should send inquiries to George H. Patterson (pattersg@mail.nih.gov). Please include an updated CV, the names and email addresses of three references, and the date of earliest availability. 

https://www.nibib.nih.gov/labs-at-nibib/section-biophotonics

Position includes salary and benefits commensurate with NIH guidelines for post-doctoral fellows.

Location: Building 13, NIH main campus, Bethesda, MD

The National Institutes of Health is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs.

Research Project Title: Understanding Cellular and Tissue Molecular Mechanical Regulation for Self-organization.

Position Description: The National Institute of Biomedical Imaging and Bioengineering (NIBIB) is seeking exceptional candidates for a Post-Doctoral Fellow position in the Intramural Research Program, in the newly established Section on Mechanobiology.

The focus of this position is on the development and use of advanced Atomic Force Microscopy (AFM) technologies for cellular and tissue mechanics work, with opportunities to work on high spatio-temporal resolution AFM and confocal fluorescent microscopies, image analysis, and mathematical modeling.

The Section on Mechanobiology seeks to elucidate the molecular-mechanical regulation of two important biological processes: (i) the molecular-mechanical regulation of the actomyosin cortex of melanoma cells and the solid tumor microenvironment for deciphering self-organization in cancer biology, and (ii) the anisotropic mechanical properties of developmental and mature inner ear sensory and non-sensory epithelial tissues using a novel noncontact AFM approach. The lab also develops new AFM methodologies to study fast multiparametric and multidimensional cellular and tissue processes, and advances the state-of the-art AFM imaging methods for high spatio-temporal and quantitative nanomechanical mapping.

Qualifications: The ideal candidate will have a Ph.D. degree in cellular biology, biophysics, biomedical or mechanical engineering, or related discipline, with some background in molecular cell biology and developmental biology, and a demonstrated ability to work in a multidisciplinary and diverse team. We are seeking a highly motivated individual who has a demonstrated record of productivity and success in scientific and engineering projects. The candidate must have experience on cellular and tissue mechanics, tissue culture, AFM imaging, optical imaging, and programming for data analysis (preferably MATLAB or R) and/or experimental devices control (preferably LabVIEW).

Position Location: Bethesda, Maryland (NIH main campus)

To Apply: Salary is determined by the NIH stipend level for Post-Doctoral Trainees and Fellows. Applicants are invited to submit a curriculum vitae including a list of publications, a maximum one-page summary of research interests, and names and contact details of three referees to Dr. Cartagena-Rivera by email at alexander.cartagena-rivera@nih.gov.

The National Institutes of Health is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs.

Research and Clinical Fellowships in the Imaging Sciences Training Program

The Imaging Sciences Training Program (ISTP), at the National Institutes of Health, jointly sponsored by Radiology and Imaging Sciences (RAD) in the Clinical Center and the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering (NIBIB), is accepting applications for one to two-year fellowship positions on a rolling admission basis. This program provides an excellent opportunity for individuals who plan a research career in imaging and biomedical sciences.

This ISTP provides opportunities in clinical, translational and basic imaging research available in Radiology and Imaging Sciences, Nuclear Medicine, Positron Emission Tomography, Interventional Radiology Laboratory and Molecular and Cellular Imaging. The program spans research in all aspects of clinical and basic imaging sciences. Applicants can choose to work in research areas including: neuroimaging, interventional, oncological, vascular, metabolic imaging and computer-aided diagnosis using various imaging techniques. There are bench-to-bedside research opportunities in MRI/MRS, MR microscopy, PET radiochemistry, contrast agent development, cellular and molecular imaging, high intensity focused ultrasound, and targeted drug delivery, and innovative image processing and visualization algorithms. Qualified applicants will also be able to have clinical exposure to a unique research patient population found at the NIH. Fellows in the ISTP will have access to state-of-the-art imaging and computer facilities dedicated to research found in the Clinical Center, In Vivo NMR Research Center, and various basic science laboratories. Collaboration with imaging scientists on the NIH campus will be encouraged.

Applicants should hold an MD, MD/PhD or PhD degree and should have completed training in radiology, nuclear medicine, biomedical engineering or a related area of the imaging sciences. Applications from individuals currently in U.S. residency programs may also be considered for research fellowship positions. Foreign graduates can also be considered for the Fogarty Visiting Fellows Program. U.S. citizenship or permanent residency is required for this full-time equivalent appointment. Salary will vary depending upon qualifications including number of years of post-residency or graduate training. NIH also provides a generous benefits package. NIH is dedicated to building a diverse community in its training and employment programs.

Candidates should submit a curriculum vitae, at least three letters of reference and a preliminary statement concerning their area of research interest to:

Dr. Joseph A. Frank
c/o Ms. Cassandra Smith
Radiology and Imaging Sciences
Building 10 Room B1N256
10 Center Drive MSC 1074
Bethesda, Maryland 20892-1074
E-mail: smithc4@cc.nih.gov

Additional information can be found at the Imaging Sciences Training Program website.

NIH is an equal opportunity employer.