Laboratory of Cellular Imaging and Macromolecular Biophysics (LCIMB)

The Laboratory of Cellular Imaging and Macromolecular Biophysics (LCIMB) specializes in the development and application of cutting-edge technologies based upon engineering, mathematics, and the physical sciences, for the solution of problems in biology and medicine. It collaborates with intramural scientists, as well as proposes and develops theoretical and experimental methods important to the long-term needs of the NIH. Its unique expertise spans technologies ranging in scale from near-atomic resolution to intact organisms.

LCIMB Sections

Nanoinstrumentation and Force Spectroscopy


The LCIMB’s Nanoinstrumentation and Force Spectroscopy (NFS) Section develops specialized instrumentations and their applications at macromolecular, cellular and tissue level in areas of biomedical research and medicine. NFS scientists collaborate closely with other intramural and extramural investigators to provide innovative approaches through biophysical modeling, mathematical analysis, and custom instrumentation primarily for nanoscale characterizations.