Cellular Imaging and Macromolecular Biophysics (LCIMB)

The NIH intramural research program has shifted all non-mission-critical laboratory operations to a maintenance phase in order to promote physical distancing and diminished transmission risk of COVID-19. Effective Monday, March 23, 2020, only mission-critical functions within NIH research laboratories will be supported.

The Laboratory of Cellular Imaging and Macromolecular Biophysics (LCIMB) specializes in the development and application of cutting-edge technologies based upon engineering, mathematics, and the physical sciences, for the solution of problems in biology and medicine. It collaborates with intramural scientists, as well as proposes and develops theoretical and experimental methods important to the long-term needs of the NIH. Its unique expertise spans technologies ranging in scale from near-atomic resolution to intact organisms.

LCIMB Sections
The CSSF develops new methods based on electron microscopy and related techniques to expand knowledge about complex biological and disease processes.
The DMA develops methods for studying reversible interactions of biological macromolecules in solution and at surfaces to understand biological binding events.
The NFS shares a biological atomic force microscopy (BioAFM) facility and develops AFM platforms to higher speed and resolution and multimodal measurements.