Creating Biomedical Technologies to Improve Health


Laboratory of Cellular Imaging and Macromolecular Biophysics (LCIMB)

This is an image of a rendered three dimensional model of a malaria infected erythrocyte obtained by scanning transmission electron tomography

The Laboratory of Cellular Imaging and Macromolecular Biophysics (LCIMB) specializes in the development and application of cutting-edge technologies based upon engineering, mathematics, and the physical sciences, for the solution of problems in biology and medicine. It collaborates with intramural scientists, as well as proposes and develops theoretical and experimental methods important to the long-term needs of the NIH. Its unique expertise spans technologies ranging in scale from near-atomic resolution to intact organisms.

The Cellular and Supramolecular Structure and Function (CSSF) Section develops new methods based on electron microscopy and related techniques with the aim of expanding knowledge about complex biological and disease processes, as well as characterizing morphologically the action of diagnostic markers and therapeutic agents.
The Dynamics of Macromolecular Assembly (DMA) Section develops methods for studying reversible interactions of biological macromolecules in solution and at surfaces with the goal of understanding the mechanisms, pathways, and functions of biological binding events.

The LCIMB’s Nanoinstrumentation and Force Spectroscopy (NFS) Section develops specialized instrumentations and their applications at macromolecular, cellular and tissue level in areas of biomedical research and medicine. NFS scientists collaborate closely with other intramural and extramural investigators to provide innovative approaches through biophysical modeling, mathematical analysis, and custom instrumentation primarily for nanoscale characterizations.