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Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)

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Staff photo of Manu Platt
Director, Biomedical Engineering Technology Acceleration (BETA Center)
Senior Investigator, MATRICES

The Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES) studies the transition of tissue from healthy to a diseased state and the underlying mechanisms driving disease progression. Of particular interest are enzymes known as proteases, which degrade extracellular matrices and other proteins. The MATRICES Lab seeks to reveal opportunities for new diagnostics and therapeutics for sickle cell disease, cancer metastasis, orthopedic diseases and other conditions. To accomplish these goals, we employ both experimental and computational approaches including label-free MRI, mechanical testing, computational modeling and analysis of gene and protein expression. Through ongoing collaborations, we aim to develop and deploy technologies in low resource settings, with a focus on diseases related to health disparities in the U.S. and around the globe.

A graphic depicting the silhouette of a person in front of genomics data, with three zoomed insets showing a cluster of cells, an artery and a single cell.

Read more about the research topics of interest to the Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES).

See a list of publications authored by the Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES).

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Staff photo of Manu Platt
Director, Biomedical Engineering Technology Acceleration (BETA Center)
Senior Investigator, MATRICES Labs/Section: Biomedical Engineering Technology Acceleration (BETA Center)
Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Audrey Noguchi
Laboratory Manager
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Tosin Adedipe
Post Baccalaureate IRTA Fellow
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Niara Botchwey
Post Baccalaureate IRTA Fellow
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of John Brandt
Biomedical Engineering Technician
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Photo of Jordyn Bryan
Post Baccalaureate IRTA Fellow
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Michael Burgess
Post Baccalaureate IRTA Fellow
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Headshot of Jacob Davis
Biomedical Engineer
Division: Labs at NIBIB Labs/Section: Biomedical Engineering Technology Acceleration (BETA Center)
Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Cydney Dennis
Postdoctoral Fellow (IRTA)
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Carey Dougan
Postdoctoral Fellow (IRTA)
Division: Labs at NIBIB Labs/Section: Biomedical Engineering Technology Acceleration (BETA Center)
Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Esohe Edomwandagbon
Post Baccalaureate (IRTA)
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Jeydi Guzman
Post Baccalaureate IRTA Fellow
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo Mohamed Ismail
Post Baccalaureate IRTA Fellow
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Hannah Song Lee.
Staff Scientist
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Andre Montes
Postdoctoral Fellow (IRTA)
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)
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Staff photo of Rahul Subramaniam
NIH Oxford-Cambridge Scholar
Division: Labs at NIBIB Labs/Section: Section on Mechanics and Tissue Remodeling Integrating Computational & Experimental Systems (MATRICES)