Section on Immunoengineering

The Section on Immunoengineering develops immune-active biomaterials for regenerative medicine through a bottom-up approach using mechanism-based immunology methods. The immune system is a critical mediator of tissue homeostasis and disease. Upon implantation of a biomaterial scaffold, an immune system response is activated, potentially with pathologic side effects including fibrosis or damaging inflammation. Furthermore, tissue growth and wound healing are modulated by immune responses. Through an understanding of how our immune system interacts with materials in the context of traumatic injury, combined with advances in biopolymers and cellular engineering, we will attempt to program immune responses to promote scaffold integration and tissue growth. Such information is critical for the advancement of next-generation materials used in non-integrating devices (i.e. pacemakers, drug delivery devices, cosmetic implants) as well as integrating medical devices (scaffolds for tissue repair). 

TED talk delivered by Kaitlyn Sadtler
Photo credit: TED/Ryan Lash

 

Mechanisms of Foreign Body Response

Implantation of a medical device induces an immune response that is characterized by protein deposits on the surface of the material and the recruitment of neutrophils and macrophages that attempt to degrade the materials with nitric oxide radicals. Subsequently, macrophages and fibroblasts deposit a dense fibrotic capsule that ultimately walls off the material from the body. While the immune system is imperative for pathogenic foreign bodies, for medical devices it can result in complications dependent upon the function of the device. Increasing our understanding of these responses to various biomaterials can lead to the improved rational design of materials that prevent immune recognition or induce immune tolerance to that device.

Patterning Immune Responses to Tissue Engineered Constructs

In the wound healing and tissue growth processes, there are specific patterns of immune activation that alter stem cell development and differentiation. Here, we seek to understand the mechanisms of immune patterning in tissue regeneration, while developing materials to help guide proper activation and inactivation of immune responses.

Tissue Specificity in Regenerative Immunoengineering

As previously mentioned, there are specific patterns of immune activation that can lead to either tissue development or pathogenesis. These patterns and activation states change for different tissue types that yield their own unique immune systems through the presence of tissue-resident immune cells. Further understanding of the differences in immune responses within these tissues (in the context of biomaterials) will create tissue-specific materials that are better tuned to the specific immunologic needs of each tissue.

Miao LLi LHuang YDelcassian DChahal JHan JShi YSadtler KGao WLin JDoloff JCLanger RAnderson DG
Nat. Biotechnol.
2019 Sep 30


Wolf MTGanguly SWang TLAnderson CWSadtler KNarain RCherry CParrillo AJPark BVWang GPan FSukumar SPardoll DMElisseeff JH
Sci Transl Med
2019 Jan 30

Sadtler KWolf MTGanguly SMoad CAChung LMajumdar SHousseau FPardoll DMElisseeff JH
Biomaterials
2019 Feb

Kaczmarek JCKauffman KJFenton OSSadtler KPatel AKHeartlein MWDeRosa FAnderson DG
Nano Lett.
2018 Oct 10

Estrellas KMChung LCheu LASadtler KMajumdar SMula JWolf MTElisseeff JHWagner KR
J. Biol. Chem.
2018 Oct 05

Gonnord PAngermann BRSadtler KGombos EChappert PMeier-Schellersheim MVarma R
Sci Signal
2018 Apr 03

Sadtler KSommerfeld SDWolf MTWang XMajumdar SChung LKelkar DSPandey AElisseeff JH
Semin. Immunol.
2017 Feb

Sadtler KAllen BWEstrellas KHousseau FPardoll DMElisseeff JH
Tissue Eng Part A
2017 Oct

Sadtler KEstrellas KAllen BWWolf MTFan HTam AJPatel CHLuber BSWang HWagner KRPowell JDHousseau FPardoll DMElisseeff JH
Science
2016 Apr 15

Beachley VZWolf MTSadtler KManda SSJacobs HBlatchley MRBader JSPandey APardoll DElisseeff JH
Nat. Methods
2015 Dec

Hillel ATSamad IMa GDing DSadtler KPowell JDLane APHorton MR
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2015 Aug