Trans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS)

The Biomedical Engineering and Physical Science (BEPS) shared resource supports NIH’s intramural basic and clinical scientists on applications of engineering, physics, imaging, measurement and analysis.  BEPS is centrally located on the main NIH campus, and provides expertise that spans technologies ranging in scale from near-atomic resolution to intact organisms. 

Biomedical engineering and physical science group photo

Please click on the links below to learn more about BEPS’s five Units:

BEPS Units

Microfabrication and Microfluidics

The Microfabrication and Microfluidics Unit specializes in: rapid design and fabrication of microfluidic devices from single or multilayer templates, microfabrication in silicon/glass, PDMS, thermoplastics, and agarose, structured surface modification, including micro contact printing, and plasma treatment of PDMS devices for irreversible bonding or for surface activation.

Quantitative Methods for Macromolecular Interactions

The Quantitative Methods for Macromolecular Interactions (QMMI) Unit specializes in the following: biophysical characterization of individual macromolecules and their interactions, measurement of solution-phase molecular weight, sedimentation coefficients, and translational diffusion coefficients, hydrodynamic radii, and overall asymmetry of macromolecules or their assemblies, establishment of the stoichiometry of complexes, and insight into secondary structure or changes in structure upon ligand binding.

Scanning Probe Microscopy Unit

The Scanning Probe Microscopy Unit specializes in nanoscale imaging of molecular complexes, lipid bilayers, cells and tissues, molecular recognition, protein unfolding, force spectroscopy, high resolution viscoelastic property mapping, correlated AFM and fluorescence microscopy, and mathematical modeling, image analysis, finite element analysis.