Dale Kiesewetter

photo of Dale Kiesewetter
Dale
Kiesewetter
Ph.D.
Chemist

BG 10 RM B2C315 10 Center Dr Bethesda MD 20814

Biography

Dr. Kiesewetter received a B.S. in chemistry and mathematics from Eureka College and subsequently obtained his Ph.D. from the University of Illinois at Urbana-Champaign. He was a student of Professor John Katzenellenbogen, a pioneer in the application of organic synthesis to study steroid hormone receptors. His Ph.D. thesis described the stereoselective radiochemical synthesis 16α-[18F]fluoroestradiol. This fluorine-18 radiolabeled steroidal estrogen has been explored for clinical application in human breast cancer throughout the years since its initial description.

Following his graduate work, he joined the group of Dr. William C. Eckelman at the NIH Clinical Center and continued work to develop novel fluorine-18 molecules directed toward the study of the muscarinic receptor system and applications in oncology.  One of the muscarinic compounds, [18F]FPTZTP, was evaluated at the NIH Clinical Center for applications in mental diseases. [18F]Paclitaxel, an analog of the clinical anticancer agent was prepared and is currently under evaluation in human subjects at the NCI.

Following the arrival of Dr. Shawn Chen and creation of the Laboratory of Molecular Imaging and Nanomedicine, Dr. Kiesewetter has been the section chief of the Chemistry and Radiochemistry Section.

Research Interests

The primary research interest is the development of methods to radiolabel biologically relevant molecules in which the introduction of 18F can be easily and efficiently accomplished.  Examples of these small molecules include the anticancer drug analog [18F]Paclitaxel, the HIV drug analog [18F]FPMPA, and the muscarinic agonist [18F]xanomeline.  An expansion of this interest is  the preparation of small radiolabeled organic prosthetic groups that can subsequently be used to radiolabel larger molecules, such as peptides or proteins. Prosthetic groups may contain hydroxysuccinimidyl esters for selective conjugation with lysine residues or maleimidyl moieties for selective conjugation with cysteine residues. Recently, we described the conjugation of [18F]FBEM (fluorobenzoylaminoethyl maleimide) with HER2-specific Affibody molecule, an scVEGF fragment and with a cysteine-containing analog of exendin-4.  These projects have yielded radiotracers with potential clinical applications.

In order to extend the probes available for PET, we have explored other available radionuclides.  The group previously had collaborative projects in the use of Br-76 (t1/2 16.2 h) and Zr-89 (t ½ 78.4h). The synthesis of NOTA modified peptides that allow complexation of [18F]aluminum fluoride as well as Ga-68 (t1/2 68 min) and Cu-64 (t1/2, 12.7 h) are used extensively in the laboratory.

Publications

Shan LFan WWang WTang WYang ZWang ZLiu YShen ZDai YCheng SJacobson OZhai KHu JMa YKiesewetter DOGao GChen X
ACS Nano
2019 Aug 06

Liu YGong CSDai YYang ZYu GLiu YZhang MLin LTang WZhou ZZhu GChen JJacobson OKiesewetter DOWang ZChen X
Biomaterials
2019 Oct

Tang LYu FTang BYang ZFan WZhang MWang ZJacobson OZhou ZLi LLiu YKiesewetter DOTang WHe LMa YNiu GZhang XChen X
ACS Appl Mater Interfaces
2019 Aug 07

Zhang MJacobson OKiesewetter DOMa YWang ZLang LTang LKang FDeng HYang WNiu GWang JChen X
Bioconjug. Chem.
2019 Jun 19

Tian RZhu SZeng QLang LMa YKiesewetter DOLiu YFu XLau JZhu GJacobson OWang ZDai YYu GBrooks BRLiu GNiu GChen X
Bioconjug. Chem.
2019 Jun 19

Tang LYang ZZhou ZMa YKiesewetter DOWang ZFan WZhu SZhang MTian RLang LNiu GZhang XChen X
Theranostics
2019

Yang WZhu GWang SYu GYang ZLin LZhou ZLiu YDai YZhang FShen ZLiu YHe ZLau JNiu GKiesewetter DOHu SChen X
ACS Nano
2019 Mar 26

Tian RMa HYang QWan HZhu SChandra SSun HKiesewetter DONiu GLiang YChen X
Chem Sci
2019 Jan 07

Niu GWang GLau JLang LJacobson OMa YKiesewetter DOZhang SChen X
Adv Healthc Mater
2019 Jun



Zhu SHu ZTian RYung BCYang QZhao SKiesewetter DONiu GSun HAntaris ALChen X
Adv. Mater. Weinheim
2018 Jul 09

Wang ZJacobson OTian RMease RCKiesewetter DONiu GPomper MGChen X
Bioconjug. Chem.
2018 Jul 18

Thompson SJPitcher MHStone LSTarum FNiu GChen XKiesewetter DOSchweinhardt PBushnell MC
Pain
2018 Sep

Shan LZhuo XZhang FDai YZhu GYung BCFan WZhai KJacobson OKiesewetter DOMa YGao GChen X
Theranostics
2018

Tian RJacobson ONiu GKiesewetter DOWang ZZhu GMa YLiu GChen X
Theranostics
2018


Chen HTong XLang LJacobson OYung BCYang XBai RKiesewetter DOMa YWu HNiu GChen X
Theranostics
2017

Jacobson OLi QChen HNiu GKiesewetter DOXu LCook KYang GDall'Acqua WTsui PPeng LChen X
J. Nucl. Med.
2017 Nov

Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X
Mol. Pharm.
2017 Apr 03

Chen HJacobson ONiu GWeiss IDKiesewetter DOLiu YMa YWu HChen X
J. Nucl. Med.
2017 Apr

Tong XWang ZSun XSong JJacobson ONiu GKiesewetter DOChen X
Theranostics
2016


Tong XSrivatsan AJacobson OWang YWang ZYang XNiu GKiesewetter DOZheng HChen X
Sci Rep
2016 Aug 22

Liu YWang ZZhang HLang LMa YHe QLu NHuang PLiu YSong JLiu ZGao SMa QKiesewetter DOChen X
Nanoscale
2016 May 19

Chen HWang GLang LJacobson OKiesewetter DOLiu YMa YZhang XWu HZhu LNiu GChen X
Theranostics
2016



Liu YWang GZhang HMa YLang LJacobson OKiesewetter DOZhu LGao SMa QChen X
Bioconjug. Chem.
2016 Jan 20

Yan XNiu GWang ZYang XKiesewetter DOJacobson OShen BChen X
Mol Imaging Biol
2016 Feb

Liu ZChen HChen KShao YKiesewetter DONiu GChen X
Sci Adv
2015 Sep

He QKiesewetter DOQu YFu XFan JHuang PLiu YZhu GLiu YQian ZChen X
Adv. Mater. Weinheim
2015 Nov

Jacobson OWeiss IDWang LWang ZYang XDewhurst AMa YZhu GNiu GKiesewetter DOVasdev NLiang SHChen X
J. Nucl. Med.
2015 Nov

Liu ZLin KSBénard FPourghiasian MKiesewetter DOPerrin DMChen X
Nat Protoc
2015 Sep

Jacobson OYan XMa YNiu GKiesewetter DOChen X
Bioconjug. Chem.
2015 Oct 21

Wang ZWang FHida NKiesewetter DOTian JNiu GChen X
Nat Protoc
2015 May

Guo NZhang FZhang XGuo JLang LKiesewetter DONiu GLi QChen X
Mol Imaging Biol
2015 Dec

Jacobson OYan XNiu GWeiss IDMa YSzajek LPShen BKiesewetter DOChen X
J. Nucl. Med.
2015 Apr


Wang YLang LHuang PWang ZJacobson OKiesewetter DOAli IUTeng GNiu GChen X
Proc. Natl. Acad. Sci. U.S.A.
2015 Jan 06

Jacobson OKiesewetter DOChen X
Bioconjug. Chem.
2015 Jan 21

Luo YYu MPan QWu WZhang TKiesewetter DOZhu ZLi FChen XZhao Y
Eur. J. Nucl. Med. Mol. Imaging
2015 Mar

Wang ZZhang RWang ZWang HFWang YZhao JWang FLi WNiu GKiesewetter DOChen X
ACS Nano
2014 Dec 23

Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X
Mol. Pharm.
2014 Nov 03

Wang YYue XKiesewetter DOWang ZLu JNiu GTeng GChen X
Mol. Pharm.
2014 Oct 06

Sun XHuang XYan XWang YGuo JJacobson OLiu DSzajek LPZhu WNiu GKiesewetter DOSun SChen X
ACS Nano
2014 Aug 26

Niu GLang LKiesewetter DOMa YSun ZGuo NGuo JWu CChen X
J. Nucl. Med.
2014 Jul


Wang ZYue XWang YQian CHuang PLizak MNiu GWang FRong PKiesewetter DOMa YChen X
Adv Healthc Mater
2014 Aug

Wang FWang ZHida NKiesewetter DOMa YYang KRong PLiang JTian JNiu GChen X
Proc. Natl. Acad. Sci. U.S.A.
2014 Apr 08


Wang YYue XKiesewetter DONiu GTeng GChen X
Eur. J. Nucl. Med. Mol. Imaging
2014 Jul


Rong PYang KSrivastan AKiesewetter DOYue XWang FNie LBhirde AWang ZLiu ZNiu GWang WChen X
Theranostics
2014

Sun XHuang XGuo JZhu WDing YNiu GWang AKiesewetter DOWang ZLSun SChen X
J. Am. Chem. Soc.
2014 Feb 05

Zhu LMa YKiesewetter DOWang YLang LLee SNiu GChen X
ACS Chem. Biol.
2014 Feb 21


Guo JLang LHu SGuo NZhu LSun ZMa YKiesewetter DONiu GXie QChen X
Mol Imaging Biol
2014 Apr


Wang ZZhang XHuang PZhao WLiu DNie LYue XWang SMa YKiesewetter DNiu GChen X
Biomaterials
2013 Aug

Zhang XXSun ZGuo JWang ZWu CNiu GMa YKiesewetter DOChen X
Mol Imaging Biol
2013 Dec

Zhang XXWang ZYue XMa YKiesewetter DOChen X
Mol. Pharm.
2013 May 06


Kiesewetter DOGuo NGuo JGao HZhu LMa YNiu GChen X
Theranostics
2012

Gao HKiesewetter DOZhang XHuang XGuo NLang LHida NWang HWang HCao FNiu GChen X
J. Nucl. Med.
2012 Dec

Pichika RTaha AYGao FKotta KCheon YChang LKiesewetter DRapoport SIEckelman WC
J. Nucl. Med.
2012 Sep

Wang HGao HGuo NNiu GMa YKiesewetter DOChen X
Theranostics
2012


Kramer-Marek GBernardo MKiesewetter DOBagci UKuban MAras OOmer AZielinski RSeidel JChoyke PCapala J
J. Nucl. Med.
2012 Jun


Huang XZhang FLee SSwierczewska MKiesewetter DOLang LZhang GZhu LGao HChoi HSNiu GChen X
Biomaterials
2012 Jun

Kramer-Marek GGijsen MKiesewetter DOBennett RRoxanis IZielinski RKong ACapala J
J. Nucl. Med.
2012 Apr

Hu SKiesewetter DOZhu LGuo NGao HLiu GHida NLang LNiu GChen X
Mol Imaging Biol
2012 Dec


Gao HLang LGuo NCao FQuan QHu SKiesewetter DONiu GChen X
Eur. J. Nucl. Med. Mol. Imaging
2012 Apr


Kiesewetter DOGao HMa YNiu GQuan QGuo NChen X
Eur. J. Nucl. Med. Mol. Imaging
2012 Mar

Liu GChoi KYBhirde ASwierczewska MYin JLee SWPark JHHong JIXie JNiu GKiesewetter DOLee SChen X
Angew. Chem. Int. Ed. Engl.
2012 Jan 09

Li WNiu GLang LGuo NMa YKiesewetter DOBacker JMShen BChen X
Eur. J. Nucl. Med. Mol. Imaging
2012 Feb

Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOPeled AEden HSFarber JMChen X
J Control Release
2012 Jan 30

Martiniova LCleary SLai EWKiesewetter DOSeidel JDawson LFPhillips JKThomasson DChen XEisenhofer GPowers JFKvetnansky RPacak K
Nucl. Med. Biol.
2012 Feb

Ravasi LTokugawa JNakayama TSeidel JSokoloff LEckelman WCKiesewetter DO
Nucl. Med. Biol.
2012 Jan

Weiss IDJacobson OKiesewetter DOJacobus JPSzajek LPChen XFarber JM
Mol Imaging Biol
2012 Feb

Lang LLi WGuo NMa YZhu LKiesewetter DOShen BNiu GChen X
Bioconjug. Chem.
2011 Dec 21

Lang LLi WJia HMFang DCZhang SSun XZhu LMa YShen BKiesewetter DONiu GChen X
Theranostics
2011

Bhattacharjee AKLang LJacobson OShinkre BMa YNiu GTrenkle WCJacobson KAChen XKiesewetter DO
Nucl. Med. Biol.
2011 Aug

Gao HNiu GYang MQuan QMa YMurage ENAhn JMKiesewetter DOChen X
Mol. Pharm.
2011 Oct 03


Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOFarber JMChen X
Theranostics
2011

Jacobson OWeiss IDNiu GBalboni GCongiu COnnis VKiesewetter DOLattanzi RSalvadori SChen X
J. Nucl. Med.
2011 Apr

Yang MGao HYan YSun XChen KQuan QLang LKiesewetter DNiu GChen X
Eur. J. Nucl. Med. Mol. Imaging
2011 Jul

Jacobson OZhu LMa YWeiss IDSun XNiu GKiesewetter DOChen X
Bioconjug. Chem.
2011 Mar 16

Jagoda EMLang LMcCullough KContoreggi CKim BMMa YRice KCSzajek LPEckelman WCKiesewetter DO
Synapse
2011 Sep

Jacobson OZhu LNiu GWeiss IDSzajek LPMa YSun XYan YKiesewetter DOLiu SChen X
Mol Imaging Biol
2011 Dec

Martiniova LPerera SMBrouwers FMAlesci SAbu-Asab MMarvelle AFKiesewetter DOThomasson DMorris JCKvetnansky RTischler ASReynolds JCFojo ATPacak K
Endocr. Relat. Cancer
2011 Feb


Gu DMa YNiu GYan YLang LAisa HAAisaand HAGao HKiesewetter DOChen X
Amino Acids
2011 Feb

Jacobson OWeiss IDKiesewetter DOFarber JMChen X
J. Nucl. Med.
2010 Nov


Ma YKiesewetter DOLang LGu DChen X
Curr. Drug Metab.
2010 Jul

Kiesewetter DOKrämer-Marek GMa YCapala J
J Fluor Chem
2008 Sep

Kiesewetter DOKnudson KCollins MSrinivasula SLim EDi Mascio M
J Labelled Comp Radiopharm
2008 Mar 13

Kramer-Marek GKiesewetter DOMartiniova LJagoda ELee SBCapala J
Eur. J. Nucl. Med. Mol. Imaging
2008 May

Di Mascio MSrinivasula SBhattacharjee ACheng LMartiniova LHerscovitch PLertora JKiesewetter D
Antimicrob. Agents Chemother.
2009 Oct




Jacobson OWeiss IDSzajek LFarber JMKiesewetter DO
Bioorg. Med. Chem.
2009 Feb 15

Kiesewetter DOLang LMa YBhattacharjee AKGao ZGJoshi BVMelman Ade Castro SJacobson KA
Nucl. Med. Biol.
2009 Jan


Vuong BKKiesewetter DOLang LMa YEckelman WCChanning MA
Nucl. Med. Biol.
2007 May


Kalen JDHirsch JIKurdziel KAEckelman WCKiesewetter DO
Appl Radiat Isot
2007 Jun


Cannon DMCarson RENugent ACEckelman WCKiesewetter DOWilliams JRollis DDrevets MGandhi SSolorio GDrevets WC
Arch. Gen. Psychiatry
2006 Jul

Jagoda EMLang LTokugawa JSimmons AMa YContoreggi CKiesewetter DEckelman WC
Synapse
2006 May

Gangloff AHsueh WAKesner ALKiesewetter DOPio BSPegram MDBeryt MTownsend ACzernin JPhelps MESilverman DH
J. Nucl. Med.
2005 Nov

Ma YLang LKiesewetter DOVuong BKChanning MIto YEckelman WC
J Chromatogr A
2004 Apr 23

Benson BECarson REKiesewetter DOHerscovitch PEckelman WCPost RMKetter TA
Neuropsychopharmacology
2004 Jul

Ma YKiesewetter DLang LEckelman WC
Mol Imaging Biol
2003

Huang BXChanning MAPlascjak PSKiesewetter DODer MMa YEckelman WC
Nucl. Med. Biol.
2003 Oct

Shimoji KEsaki TItoh YRavasi LCook MJehle JJagoda EMKiesewetter DOSchmidt KSokoloff LEckelman WC
Synapse
2003 Nov

Kurdziel KAKiesewetter DOCarson REEckelman WCHerscovitch P
J. Nucl. Med.
2003 Aug

Cohen RMPodruchny TABokde ALCarson REHerscovitch PKiesewetter DOEckelman WCSunderland T
Synapse
2003 Sep 01


Podruchny TAConnolly CBokde AHerscovitch PEckelman WCKiesewetter DOSunderland TCarson RECohen RM
Synapse
2003 Apr

Kiesewetter DOVuong BKChanning MA
Nucl. Med. Biol.
2003 Jan

Kiesewetter DOJagoda EMKao CHMa YRavasi LShimoji KSzajek LPEckelman WC
Nucl. Med. Biol.
2003 Jan