1. About NIBIB
  2. Staff Directory
  3. Lixin Lang

Lixin Lang

Lixin Lang
Lixin
Lang
Ph.D.
Staff Scientist
Molecular Imaging and Nanomedicine (LOMIN)
Molecular Probes and Imaging Agents

BG 10 RM B2C315 10 CENTER DR BETHESDA MD 20814

Clickable Telephone icon
301-451-3532
Clickable Email icon
llang@mail.nih.gov
Biography

Dr. Lang received his B.S. in Radiation Chemistry from the University of Technology of China in 1983; a Master of Science in Radiochemistry from the Shanghai Institute of Nuclear Research in 1986; and his Ph.D. in Radiopharmaceutical Chemistry from the University of Missouri-Columbia in 1992. He began his NIH career as an international fellow in the Clinical Center PET Department in 1992, and accepted a staff scientist position in 1998. Dr. Lang joined NIBIB in October 2004 when the Clinical Center Radiochemistry Section was realigned and became an organizational component of NIBIB’s Intramural Science Program.

Publications
A Metabolically Stable Boron-Derived Tyrosine Serves as a Theranostic Agent for Positron Emission Tomography Guided Boron Neutron Capture Therapy.
Li JShi YZhang ZLiu HLang LLiu TChen XLiu Z
Bioconjug. Chem.
2019 Oct 14

68Ga-NOTA-Aca-BBN(7-14) PET imaging of GRPR in children with optic pathway glioma.
Zhang JTian YLi DNiu GLang LLi FLiu YZhu ZChen X
Eur. J. Nucl. Med. Mol. Imaging
2019 Sep

Improving the Theranostic Potential of Exendin 4 by Reducing the Renal Radioactivity through Brush Border Membrane Enzyme-Mediated Degradation.
Zhang MJacobson OKiesewetter DOMa YWang ZLang LTang LKang FDeng HYang WNiu GWang JChen X
Bioconjug. Chem.
2019 Jun 19

An Albumin-Binding T- T Dual-Modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging.
Zhou ZBai RWang ZBryant HLang LMerkle HMunasinghe JTang LTang WTian RYu GMa YNiu GGao JChen X
Bioconjug. Chem.
2019 Jun 19

An Albumin Sandwich Enhances in Vivo Circulation and Stability of Metabolically Labile Peptides.
Tian RZhu SZeng QLang LMa YKiesewetter DOLiu YFu XLau JZhu GJacobson OWang ZDai YYu GBrooks BRLiu GNiu GChen X
Bioconjug. Chem.
2019 Jun 19

A Logic-Gated Modular Nanovesicle Enables Programmable Drug Release for On-Demand Chemotherapy.
Tang LYang ZZhou ZMa YKiesewetter DOWang ZFan WZhu SZhang MTian RLang LNiu GZhang XChen X
Theranostics
2019

Antidiabetic Effect of Abextide, a Long-Acting Exendin-4 Analogue in Cynomolgus Monkeys.
Niu GWang GLau JLang LJacobson OMa YKiesewetter DOZhang SChen X
Adv Healthc Mater
2019 Jun

Single Low-Dose Injection of Evans Blue Modified PSMA-617 Radioligand Therapy Eliminates Prostate-Specific Membrane Antigen Positive Tumors.
Wang ZTian RNiu GMa YLang LSzajek LPKiesewetter DOJacobson OChen X
Bioconjug. Chem.
2018 Sep 19

Combined 68Ga-NOTA-PRGD2 and 18F-FDG PET/CT Can Discriminate Uncommon Meningioma Mimicking High-Grade Glioma.
Li DZhang JJi NZhao XZheng KQiao ZLi FLang LIagaru ANiu GZhu ZChen X
Clin Nucl Med
2018 Sep

68Ga-NOTA-RM26 PET/CT in the Evaluation of Breast Cancer: A Pilot Prospective Study.
Zang JMao FWang HZhang JLiu QPeng LLi FLang LChen XZhu Z
Clin Nucl Med
2018 Sep

First-in-human study of PET and optical dual-modality image-guided surgery in glioblastoma using Ga-IRDye800CW-BBN.
Li DZhang JChi CXiao XWang JLang LAli INiu GZhang LTian JJi NZhu ZChen X
Theranostics
2018

Predictive probability methods for interim monitoring in clinical trials with longitudinal outcomes.
Zhou MTang QLang LXing JTatsuoka K
Stat Med
2018 Jun 30

68Ga-BBN-RGD PET/CT for GRPR and Integrin αvβ3 Imaging in Patients with Breast Cancer.
Zhang JMao FNiu GPeng LLang LLi FYing HWu HPan BZhu ZChen X
Theranostics
2018

Positron Emission Tomography Imaging of Prostate Cancer with Ga-68-Labeled Gastrin-Releasing Peptide Receptor Agonist BBN and Antagonist RM26.
Cheng SLang LWang ZJacobson OYung BZhu GGu DMa YZhu XNiu GChen X
Bioconjug. Chem.
2018 Feb 21

PET Using a GRPR Antagonist Ga-RM26 in Healthy Volunteers and Prostate Cancer Patients.
Zhang JNiu GFan XLang LHou GChen LWu HZhu ZLi FChen X
J. Nucl. Med.
2018 Jun

Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy.
Zhu GLynn GMJacobson OChen KLiu YZhang HMa YZhang FTian RNi QCheng SWang ZLu NYung BCWang ZLang LFu XJin AWeiss IDVishwasrao HNiu GShroff HKlinman DMSeder RAChen X
Nat Commun
2017 Dec 05

Quantification of Tumor Vascular Permeability and Blood Volume by Positron Emission Tomography.
Chen HTong XLang LJacobson OYung BCYang XBai RKiesewetter DOMa YWu HNiu GChen X
Theranostics
2017

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial.
El-Khoueiry ABSangro BYau TCrocenzi TSKudo MHsu CKim TYChoo SPTrojan JWelling THMeyer TKang YKYeo WChopra AAnderson JDela Cruz CLang LNeely JTang HDastani HBMelero I
Lancet
2017 Jun 24

Microsurgery guided by sequential preoperative lymphography using Ga-NEB PET and MRI in patients with lower-limb lymphedema.
Long XZhang JZhang DGao CChi CYang EXue HLang LNiu GZhu ZLi FChen X
Eur. J. Nucl. Med. Mol. Imaging
2017 Aug

Clinical Translation of a Dual Integrin αvβ3- and Gastrin-Releasing Peptide Receptor-Targeting PET Radiotracer, 68Ga-BBN-RGD.
Zhang JNiu GLang LLi FFan XYan XYao SYan WHuo LChen LLi ZZhu ZChen X
J. Nucl. Med.
2017 Feb

A photothermally responsive nanoprobe for bioimaging based on Edman degradation.
Liu YWang ZZhang HLang LMa YHe QLu NHuang PLiu YSong JLiu ZGao SMa QKiesewetter DOChen X
Nanoscale
2016 May 19

Chemical Conjugation of Evans Blue Derivative: A Strategy to Develop Long-Acting Therapeutics through Albumin Binding.
Chen HWang GLang LJacobson OKiesewetter DOLiu YMa YZhang XWu HZhu LNiu GChen X
Theranostics
2016

Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment.
Liu YWang GZhang HMa YLang LJacobson OKiesewetter DOZhu LGao SMa QChen X
Bioconjug. Chem.
2016 Jan 20

68Ga-NOTA-Aca-BBN(7-14) PET/CT in Healthy Volunteers and Glioma Patients.
Zhang JLi DLang LZhu ZWang LWu PNiu GLi FChen X
J. Nucl. Med.
2016 Jan

68Ga-NOTA-PRGD2 PET/CT for Integrin Imaging in Patients with Lung Cancer.
Zheng KLiang NZhang JLang LZhang WLi SZhao JNiu GLi FZhu ZChen X
J. Nucl. Med.
2015 Dec

Clinical Translation of an Albumin-Binding PET Radiotracer 68Ga-NEB.
Zhang JLang LZhu ZLi FNiu GChen X
J. Nucl. Med.
2015 Oct

(18)F-Alfatide II PET/CT in healthy human volunteers and patients with brain metastases.
Yu CPan DMi BXu YLang LNiu GYang MWan WChen X
Eur. J. Nucl. Med. Mol. Imaging
2015 Dec

Quantitative Evaluation of Tumor Early Response to a Vascular-Disrupting Agent with Dynamic PET.
Guo NZhang FZhang XGuo JLang LKiesewetter DONiu GLi QChen X
Mol Imaging Biol
2015 Dec

In vivo albumin labeling and lymphatic imaging.
Wang YLang LHuang PWang ZJacobson OKiesewetter DOAli IUTeng GNiu GChen X
Proc. Natl. Acad. Sci. U.S.A.
2015 Jan 06

In Vivo Labeling of Serum Albumin for PET.
Niu GLang LKiesewetter DOMa YSun ZGuo NGuo JWu CChen X
J. Nucl. Med.
2014 Jul

Longitudinal PET imaging of muscular inflammation using 18F-DPA-714 and 18F-Alfatide II and differentiation with tumors.
Wu CYue XLang LKiesewetter DOLi FZhu ZNiu GChen X
Theranostics
2014

Stability analysis of glutamic acid linked peptides coupled to NOTA through different chemical linkages.
Lang LMa YKiesewetter DOChen X
Mol. Pharm.
2014 Nov 03

Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity.
Zhu LMa YKiesewetter DOWang YLang LLee SNiu GChen X
ACS Chem. Biol.
2014 Feb 21

(18)F-alfatide II and (18)F-FDG dual-tracer dynamic PET for parametric, early prediction of tumor response to therapy.
Guo JGuo NLang LKiesewetter DOXie QLi QEden HSNiu GChen X
J. Nucl. Med.
2014 Jan

Comparison of three dimeric 18F-AlF-NOTA-RGD tracers.
Guo JLang LHu SGuo NZhu LSun ZMa YKiesewetter DONiu GXie QChen X
Mol Imaging Biol
2014 Apr

PET of glucagonlike peptide receptor upregulation after myocardial ischemia or reperfusion injury.
Gao HKiesewetter DOZhang XHuang XGuo NLang LHida NWang HWang HCao FNiu GChen X
J. Nucl. Med.
2012 Dec

Immuno-PET of the hepatocyte growth factor receptor Met using the 1-armed antibody onartuzumab.
Jagoda EMLang LBhadrasetty VHisted SWilliams MKramer-Marek GMena ERosenblum LMarik JTinianow JNMerchant MSzajek LPaik CCecchi FRaffensperger KJose-Dizon JMBottaro DPChoyke P
J. Nucl. Med.
2012 Oct

Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model.
Guo NLang LLi WKiesewetter DOGao HNiu GXie QChen X
PLoS ONE
2012

Quantitative analysis and parametric imaging of 18F-labeled monomeric and dimeric RGD peptides using compartment model.
Guo NLang LGao HNiu GKiesewetter DOXie QChen X
Mol Imaging Biol
2012 Dec

Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes.
Huang XZhang FLee SSwierczewska MKiesewetter DOLang LZhang GZhu LGao HChoi HSNiu GChen X
Biomaterials
2012 Jun

Longitudinal PET imaging of doxorubicin-induced cell death with 18F-Annexin V.
Hu SKiesewetter DOZhu LGuo NGao HLiu GHida NLang LNiu GChen X
Mol Imaging Biol
2012 Dec

Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS.
Ma YYang MGao HNiu GYan YLang LKiesewetter DOChen X
Amino Acids
2012 Oct

PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2.
Gao HLang LGuo NCao FQuan QHu SKiesewetter DONiu GChen X
Eur. J. Nucl. Med. Mol. Imaging
2012 Apr

N-Succinimidyl 4-[(18)F]-fluoromethylbenzoate-labeled dimeric RGD peptide for imaging tumor integrin expression.
Li WLang LNiu GGuo NMa YKiesewetter DOShen BChen X
Amino Acids
2012 Sep

PET imaging of EGF receptors using [18F]FBEM-EGF in a head and neck squamous cell carcinoma model.
Li WNiu GLang LGuo NMa YKiesewetter DOBacker JMShen BChen X
Eur. J. Nucl. Med. Mol. Imaging
2012 Feb

Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice.
Lang LLi WGuo NMa YZhu LKiesewetter DOShen BNiu GChen X
Bioconjug. Chem.
2011 Dec 21

New Methods for Labeling RGD Peptides with Bromine-76.
Lang LLi WJia HMFang DCZhang SSun XZhu LMa YShen BKiesewetter DONiu GChen X
Theranostics
2011

Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425.
Bhattacharjee AKLang LJacobson OShinkre BMa YNiu GTrenkle WCJacobson KAChen XKiesewetter DO
Nucl. Med. Biol.
2011 Aug

F-Labeled GRPR Agonists and Antagonists: A Comparative Study in Prostate Cancer Imaging.
Yang MGao HZhou YMa YQuan QLang LChen KNiu GYan YChen X
Theranostics
2011

PET imaging of early response to the tyrosine kinase inhibitor ZD4190.
Yang MGao HYan YSun XChen KQuan QLang LKiesewetter DNiu GChen X
Eur. J. Nucl. Med. Mol. Imaging
2011 Jul

[(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor.
Jagoda EMLang LMcCullough KContoreggi CKim BMMa YRice KCSzajek LPEckelman WCKiesewetter DO
Synapse
2011 Sep

Automated radiochemical synthesis of [18F]FBEM: a thiol reactive synthon for radiofluorination of peptides and proteins.
Kiesewetter DOJacobson OLang LChen X
Appl Radiat Isot
2011 Feb

LC/MS evaluation of metabolism and membrane transport of bombesin peptides.
Gu DMa YNiu GYan YLang LAisa HAAisaand HAGao HKiesewetter DOChen X
Amino Acids
2011 Feb

Applications of LC-MS in PET radioligand development and metabolic elucidation.
Ma YKiesewetter DOLang LGu DChen X
Curr. Drug Metab.
2010 Jul

Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography.
Spinelli SChefer SCarson REJagoda ELang LHeilig MBarr CSSuomi SJHigley JDStein EA
Biol. Psychiatry
2010 Jun 15

Application of highly sensitive UPLC-MS to determine biodistribution at tracer doses: validation with the 5-HT1A ligand [(18)F]FPWAY.
Ma YLang LReyes LTokugawa JJagoda EMKiesewetter DO
Nucl. Med. Biol.
2009 May

Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography.
Kiesewetter DOLang LMa YBhattacharjee AKGao ZGJoshi BVMelman Ade Castro SJacobson KA
Nucl. Med. Biol.
2009 Jan

An automated one-step one-pot [(18)F]FCWAY synthesis: development and minimization of chemical impurities.
Vuong BKKiesewetter DOLang LMa YEckelman WCChanning MA
Nucl. Med. Biol.
2007 May

Distribution of the 5-HT(1A) receptor antagonist [ (18)F]FPWAY in blood and brain of the rat with and without isoflurane anesthesia.
Tokugawa JRavasi LNakayama TLang LSchmidt KCSeidel JGreen MVSokoloff LEckelman WC
Eur. J. Nucl. Med. Mol. Imaging
2007 Feb

5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction.
Giovacchini GToczek MTBonwetsch RBagic ALang LFraser CReeves-Tyer PHerscovitch PEckelman WCCarson RETheodore WH
J. Nucl. Med.
2005 Jul

Differential effects of paroxetine on raphe and cortical 5-HT1A binding: a PET study in monkeys.
Giovacchini GLang LMa YHerscovitch PEckelman WCCarson RE
Neuroimage
2005 Oct 15

Purification of the precursor for the automated radiosynthesis of [18F]FCWAY by counter-current chromatography.
Ma YLang LKiesewetter DOVuong BKChanning MIto YEckelman WC
J Chromatogr A
2004 Apr 23

Application of LC-MS to the analysis of new radiopharmaceuticals.
Ma YKiesewetter DLang LEckelman WC
Mol Imaging Biol
2003

Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid-liquid and solid phase extractions.
Ma YKiesewetter DOLang LDer MHuang BCarson REEckelman WC
Nucl. Med. Biol.
2003 Apr

Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs.
Carson REWu YLang LMa YDer MGHerscovitch PEckelman WC
J. Cereb. Blood Flow Metab.
2003 Feb