Orit Jacobson Weiss

Orit Jacobson Weiss
Orit
Jacobson Weiss
Ph.D.
Staff Scientist

Building 10, Room B2C315

9000 Rockville Pike

Bethesda, Maryland, 20892

Biography

Dr. Jacobson Weiss received her Ph.D. in 2008 from the Hebrew University at Jerusalem, Israel, in radiochemistry and molecular imaging.  Dr. Jacobson Weiss’ thesis focused on the development of novel PET tracers targeting the EGF and androgen receptors in order to test expression of the receptors by tumors as well as monitor treatment efficiency.  As part of her thesis, Dr. Jacobson Weiss developed and applied new labeling methods with carbon-11 and fluorine-18.

From 2008 to 2011 Dr. Jacobson Weiss trained as a postdoc at NIBIB/NIH in Bethesda, Maryland. The main projects she focused on were imaging of chemokine receptor CXCR4 by small molecules and peptides and imaging of prokineticin receptor. Two of Dr. Jacobson Weiss’ CXCR4 PET tracers were translated into the clinic and evaluated in human cancer subjects.

In 2011 Dr. Jacobson Weiss returned to Hadassah Medical Organization in Jerusalem, Israel, as the head of the radiochemistry and chemistry group of the cyclotron unit and supervised both clinical production of PET tracers as well as research.

After two and a half years, Dr. Jacobson Weiss came back to the NIBIB/NIH as a staff scientist in order to focus on research and development of new radiotracers and direct/indirect labeling routes of a peptide. Her research projects include radiolabeling antibodies, peptides, and DNA oligomers for imaging and radiotherapy applications.  

Over the last few years Dr. Jacobson Weiss developed a new EB derivative denoted as DMEB, which contains two functional groups: a maleimide for thiol conjugation and a DOTA chelator that allows labeling with metal isotopes for nuclear imaging and radiotherapy. The newly designed truncated EB form can be conjugated to various molecules including small molecules, peptides, proteins, and aptamers. DMEB conjugation improves blood half-life and tumor uptake, thereby significantly enhancing imaging, therapy, and radiotherapy while reducing the amount of radioactivity administered to the patient. Two of the derivatives were translated to the clinic targeting Somatostatin receptor subtype 2 (SSTR2) for pancreatic cancer and Prostate-specific membrane antigen (PSMA). Both derivatives were labeled with the radiotherapeutic isotope, Lu-177 and showed promising results.

Publications
Li LYang ZFan WHe LCui CZou JTang WJacobson OWang ZNiu GHu SChen X
Adv Funct Mater
2020 Jan 23

Mu JHe LFan WTang WWang ZJiang CZhang DLiu YDeng HZou JJacobson OQu JHuang PChen X
Small
2020 Sep 28

Zhao LChen HGuo ZFu KYao LFu LGuo WWen XJacobson OZhang XSun LWu HLin QChen X
Mol Cancer Ther
2020 Oct

Liu QZang JSui HRen JGuo HWang HWang RJacobson OZhang JCheng YZhu ZChen X
J Nucl Med
2020 Aug 21

Tang LWang ZMu QYu ZJacobson OLi LYang WHuang CKang FFan WMa YWang MZhou ZChen X
Adv Mater
2020 Aug

Wang SZhang FYu GWang ZJacobson OMa YTian RDeng HYang WChen ZYChen X
Theranostics
2020

Zhou ZDeng HYang WWang ZLin LMunasinghe JJacobson OLiu YTang LNi QKang FLiu YNiu GBai RQian CSong JChen X
Nat Commun
2020 Jun 15

Zang JLiu QSui HWang RJacobson OFan XZhu ZChen X
J Nucl Med
2020 May 01

He LNi QMu JFan WLiu LWang ZLi LTang WLiu YCheng YTang LYang ZLiu YZou JYang WJacobson OZhang FHuang PChen X
J Am Chem Soc
2020 Apr 08




Yang ZDai YShan LShen ZWang ZYung BCJacobson OLiu YTang WWang SLin LNiu GHuang PChen X
Nanoscale Horiz
2019 Mar 01

Wang JSang WYang ZShen ZWang ZJacobson OChen YWang YShao MNiu GDai YChen X
J Mater Chem B
2019 Oct 07

Yang ZFan WZou JTang WLi LHe LShen ZWang ZJacobson OAronova MARong PSong JWang WChen X
J Am Chem Soc
2019 Sep 18

Wang SYu GWang ZJacobson OLin LSYang WDeng HHe ZLiu YChen ZYChen X
Angew Chem Int Ed Engl
2019 Oct 07


Shan LFan WWang WTang WYang ZWang ZLiu YShen ZDai YCheng SJacobson OZhai KHu JMa YKiesewetter DOGao GChen X
ACS Nano
2019 Aug 27

Liu YGong CSDai YYang ZYu GLiu YZhang MLin LTang WZhou ZZhu GChen JJacobson OKiesewetter DOWang ZChen X
Biomaterials
2019 Oct

Tang LYu FTang BYang ZFan WZhang MWang ZJacobson OZhou ZLi LLiu YKiesewetter DOTang WHe LMa YNiu GZhang XChen X
ACS Appl Mater Interfaces
2019 Aug 07

Zhang MJacobson OKiesewetter DOMa YWang ZLang LTang LKang FDeng HYang WNiu GWang JChen X
Bioconjug Chem
2019 Jun 19

Tian RZhu SZeng QLang LMa YKiesewetter DOLiu YFu XLau JZhu GJacobson OWang ZDai YYu GBrooks BRLiu GNiu GChen X
Bioconjug Chem
2019 Jun 19

Tang WFan WWang ZZhang WZhou SLiu YYang ZShao EZhang GJacobson OShan LTian RCheng SLin LDai YShen ZNiu GXie JChen X
ACS Nano
2019 May 28


He ZHuang XWang CLi XLiu YZhou ZWang SZhang FWang ZJacobson OZhu JJYu GDai YChen X
Angew Chem Int Ed Engl
2019 Jun 24

Yu GCen TYHe ZWang SPWang ZYing XWLi SJacobson OWang SWang LLin LSTian RZhou ZNi QLi XChen X
Angew Chem Int Ed Engl
2019 Jun 24

Wang JZang JWang HLiu QLi FLin YHuo LJacobson ONiu GFan XZhu ZChen X
Clin Nucl Med
2019 Jun

Tang WFan WZhang WYang ZLi LWang ZChiang YLLiu YDeng LHe LShen ZJacobson OAronova MAJin AXie JChen X
Adv Mater
2019 May


Wang SWang ZYu GZhou ZJacobson OLiu YMa YZhang FChen ZYChen X
Adv Sci (Weinh)
2019 Mar 06

Fan WLu NShen ZTang WShen BCui ZShan LYang ZWang ZJacobson OZhou ZLiu YHu PYang WSong JZhang YZhang LKhashab NMAronova MALu GChen X
Nat Commun
2019 Mar 18

Lau JJacobson ONiu GLin KSBénard FChen X
Bioconjug Chem
2019 Mar 20


Niu GWang GLau JLang LJacobson OMa YKiesewetter DOZhang SChen X
Adv Healthc Mater
2019 Jun

Zang JFan XWang HLiu QWang JLi HLi FJacobson ONiu GZhu ZChen X
Eur J Nucl Med Mol Imaging
2019 Jan

Cheng SJacobson OZhu GChen ZLiang SHTian RYang ZNiu GZhu XChen X
Eur J Nucl Med Mol Imaging
2019 Apr

Tang WFan WWang ZZhang WZhou SLiu YYang ZShao EZhang GJacobson OShan LTian RCheng SLin LDai YShen ZNiu GXie JChen X
ACS Nano
2018 Dec 26

Yang ZFan WTang WShen ZDai YSong JWang ZLiu YLin LShan LLiu YJacobson ORong PWang WChen X
Angew Chem Int Ed Engl
2018 Oct 22

Wang SYu GWang ZJacobson OTian RLin LSZhang FWang JChen X
Adv Mater
2018 Aug 31

Cheng SJacobson OZhu GChen ZLiang SHTian RYang ZNiu GZhu XChen X
Eur J Nucl Med Mol Imaging
2018 Nov




Yu GZhao XZhou JMao ZHuang XWang ZHua BLiu YZhang FHe ZJacobson OGao CWang WYu CZhu XHuang FChen X
J Am Chem Soc
2018 Jun 27

Wang ZJacobson OTian RMease RCKiesewetter DONiu GPomper MGChen X
Bioconjug Chem
2018 Jul 18

Zhou ZChan AWang ZHuang XYu GJacobson OWang SLiu YShan LDai YShen ZLin LChen WChen X
Angew Chem Int Ed Engl
2018 Jul 09


Zhang FNi QJacobson OCheng SLiao AWang ZHe ZYu GSong JMa YNiu GZhang LZhu GChen X
Angew Chem Int Ed Engl
2018 Jun 11

Shan LZhuo XZhang FDai YZhu GYung BCFan WZhai KJacobson OKiesewetter DOMa YGao GChen X
Theranostics
2018

Yu GYang ZFu XYung BCYang JMao ZShao LHua BLiu YZhang FFan QWang SJacobson OJin AGao CTang XHuang FChen X
Nat Commun
2018 Feb 22

Lu NFan WYi XWang SWang ZTian RJacobson OLiu YYung BCZhang GTeng ZYang KZhang MNiu GLu GChen X
ACS Nano
2018 Feb 27

Tian RJacobson ONiu GKiesewetter DOWang ZZhu GMa YLiu GChen X
Theranostics
2018

Dai YYang ZCheng SWang ZZhang RZhu GWang ZYung BCTian RJacobson OXu CNi QSong JSun XNiu GChen X
Adv Mater
2018 Feb

Dai YCheng SWang ZZhang RYang ZWang JYung BCWang ZJacobson OXu CNi QYu GZhou ZChen X
ACS Nano
2018 Jan 23

Wang ZDai YWang ZJacobson OZhang FYung BCZhang PGao HNiu GLiu GChen X
Nanoscale
2018 Jan 18


Zhu GLynn GMJacobson OChen KLiu YZhang HMa YZhang FTian RNi QCheng SWang ZLu NYung BCWang ZLang LFu XJin AWeiss IDVishwasrao HNiu GShroff HKlinman DMSeder RAChen X
Nat Commun
2017 Dec 05

Zhu GMei LVishwasrao HDJacobson OWang ZLiu YYung BCFu XJin ANiu GWang QZhang FShroff HChen X
Nat Commun
2017 Nov 14

Liu YWang ZLiu YZhu GJacobson OFu XBai RLin XLu NYang XFan WSong JWang ZYu GZhang FKalish HNiu GNie ZChen X
ACS Nano
2017 Oct 24

Zhang FZhu GJacobson OLiu YChen KYu GNi QFan JYang ZXu FFu XWang ZMa YNiu GZhao XChen X
ACS Nano
2017 Sep 26

Chen HTong XLang LJacobson OYung BCYang XBai RKiesewetter DOMa YWu HNiu GChen X
Theranostics
2017

Wang SLin JWang ZZhou ZBai RLu NLiu YFu XJacobson OFan WQu JChen SWang THuang PChen X
Adv Mater
2017 Sep

Song JYang XYang ZLin LLiu YZhou ZShen ZYu GDai YJacobson OMunasinghe JYung BTeng GJChen X
ACS Nano
2017 Jun 27

Jacobson OLi QChen HNiu GKiesewetter DOXu LCook KYang GDall'Acqua WTsui PPeng LChen X
J Nucl Med
2017 Nov

Kim YHMin KHWang ZKim JJacobson OHuang PZhu GLiu YYung BNiu GChen X
Theranostics
2017

Yang ZTian RWu JFan QYung BCNiu GJacobson OWang ZLiu GYu GHuang WSong JChen X
ACS Nano
2017 Apr 25


Zhu GZhang HJacobson OWang ZChen HYang XNiu GChen X
Bioconjug Chem
2017 Apr 19

Sun XYan XJacobson OSun WWang ZTong XXia YLing DChen X
Theranostics
2017

Xu CYang XFu XTian RJacobson OWang ZLu NLiu YFan WZhang FNiu GHu SAli IUChen X
Adv Mater
2017 Feb


Tong XWang ZSun XSong JJacobson ONiu GKiesewetter DOChen X
Theranostics
2016


Tong XSrivatsan AJacobson OWang YWang ZYang XNiu GKiesewetter DOZheng HChen X
Sci Rep
2016 Aug 22

Lin JWang MHu HYang XWen BWang ZJacobson OSong JZhang GNiu GHuang PChen X
Adv Mater
2016 May

Chen HWang GLang LJacobson OKiesewetter DOLiu YMa YZhang XWu HZhu LNiu GChen X
Theranostics
2016

Wang ZHuang PJacobson OWang ZLiu YLin LLin JLu NZhang HTian RNiu GLiu GChen X
ACS Nano
2016 Mar 22

Liu YWang GZhang HMa YLang LJacobson OKiesewetter DOZhu LGao SMa QChen X
Bioconjug Chem
2016 Jan 20

Yan XNiu GWang ZYang XKiesewetter DOJacobson OShen BChen X
Mol Imaging Biol
2016 Feb

Jacobson OWeiss IDWang LWang ZYang XDewhurst AMa YZhu GNiu GKiesewetter DOVasdev NLiang SHChen X
J Nucl Med
2015 Nov

Wang LJacobson OAvdic DRotstein BHWeiss IDCollier LChen XVasdev NLiang SH
Angew Chem Int Ed Engl
2015 Oct 19



Song JYang XJacobson OHuang PSun XLin LYan XNiu GMa QChen X
Adv Mater
2015 Sep 02

Jacobson OYan XMa YNiu GKiesewetter DOChen X
Bioconjug Chem
2015 Oct 21

Wang ZZhang MWang LWang SKang FLi GJacobson ONiu GYang WWang JChen X
Theranostics
2015

Jacobson OYan XNiu GWeiss IDMa YSzajek LPShen BKiesewetter DOChen X
J Nucl Med
2015 Apr


Wang YLang LHuang PWang ZJacobson OKiesewetter DOAli IUTeng GNiu GChen X
Proc Natl Acad Sci U S A
2015 Jan 06

Jacobson OKiesewetter DOChen X
Bioconjug Chem
2015 Jan 21


Orevi MFreedman NMishani EBocher MJacobson OKrausz Y
Clin Nucl Med
2014 Dec

Hu HHuang PWeiss OJYan XYue XZhang MGTang YNie LMa YNiu GWu KChen X
Biomaterials
2014 Dec

Sun XHuang XYan XWang YGuo JJacobson OLiu DSzajek LPZhu WNiu GKiesewetter DOSun SChen X
ACS Nano
2014 Aug 26


Niu GMurad YMGao HHu SGuo NJacobson ONguyen TDZhang JChen X
J Control Release
2012 Jul 10

Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOPeled AEden HSFarber JMChen X
J Control Release
2012 Jan 30

Zhang FNiu GLin XJacobson OMa YEden HSHe YLu GChen X
Amino Acids
2012 Jun

Weiss IDJacobson OKiesewetter DOJacobus JPSzajek LPChen XFarber JM
Mol Imaging Biol
2012 Feb

Bhattacharjee AKLang LJacobson OShinkre BMa YNiu GTrenkle WCJacobson KAChen XKiesewetter DO
Nucl Med Biol
2011 Aug


Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOFarber JMChen X
Theranostics
2011

Jacobson OWeiss IDNiu GBalboni GCongiu COnnis VKiesewetter DOLattanzi RSalvadori SChen X
J Nucl Med
2011 Apr

Zhou YKim YSShi JJacobson OChen XLiu S
Bioconjug Chem
2011 Apr 20

Jacobson OZhu LMa YWeiss IDSun XNiu GKiesewetter DOChen X
Bioconjug Chem
2011 Mar 16

Jacobson OZhu LNiu GWeiss IDSzajek LPMa YSun XYan YKiesewetter DOLiu SChen X
Mol Imaging Biol
2011 Dec


Jacobson OWeiss IDKiesewetter DOFarber JMChen X
J Nucl Med
2010 Nov

Jacobson OChen X
Curr Top Med Chem
2010

Jacobson OWeiss IDSzajek LFarber JMKiesewetter DO
Bioorg Med Chem
2009 Feb 15

Jacobson OMishani E
Appl Radiat Isot
2008 Feb

Jacobson OLaky DCarlson KEElgavish SGozin MEven-Sapir ELeibovitc IGutman MChisin RKatzenellenbogen JAMishani E
Nucl Med Biol
2006 Aug


Jacobson OBechor YIcar ANovak NBirman AMarom HFadeeva LGolan ELeibovitch IGutman MEven-Sapir EChisin RGozin MMishani E
Bioorg Med Chem
2005 Nov 15

Shaul MAbourbeh GJacobson ORozen YLaky DLevitzki AMishani E
Bioorg Med Chem
2004 Jul 01