Ying Ma

Ying Ma
Ying
Ma
Ph.D.
Staff Scientist

BG 10 RM B2C315 10 CENTER DR BETHESDA MD 20814

Biography

Dr. Ying Ma received a Ph.D. in Medicinal Chemistry in 1992 from Beijing Medical University, Beijing, China, and joined NIH the following year as a visiting fellow. His work with the National Heart, Lung, and Blood Institute (NHLBI), and the National Eye Institute (NEI), was in the area of analytical chemistry, developing separation methods for biologically active molecules. He obtained two patents on chiral separation and affinity countercurrent chromatography. He joined the PET Department of Clinical Center as an analytical chemist in 1999, and then moved to NIBIB's Intramural Program in 2004.

Research Interests

Dr. Ma’s current research focuses on the development and application of mass spectrometry techniques for evaluation of molecular imaging probes:

Positron emission tomography (PET) is a powerful technique with the ability to measure target density changes by external imaging.  Because the imaging technique cannot differentiate between the parent and radioactive metabolites, determination of the chemical component(s) in the target tissue is required.  When designing molecular imaging probes, the metabolic fate is evaluated using hepatocytes to generate metabolites and using LC-MS to suggest metabolite structures.  From these early metabolite analyses, the chemical structure of imaging probes can be modified in an attempt to minimize interfering radiometabolites in the target tissue.

The value of LC/MS as a complementary research tool to evaluate the primary biodistribution of molecular imaging probes has been demonstrated in our lab. Due to the high sensitivity of MS for various molecules, tissue uptake of molecular imaging probes can be quantitatively evaluated at the tracer level without the need for radiolabeling. The time course of uptake and the effect of mass dose on that uptake can be determined directly and both identification and quantitation of metabolites are possible.

Publications
Deng HYang WZhou ZTian RLin LMa YSong JChen X
Nat Commun
2020 Oct 02

Tang LWang ZMu QYu ZJacobson OLi LYang WHuang CKang FFan WMa YWang MZhou ZChen X
Adv Mater
2020 Aug

Wang SZhang FYu GWang ZJacobson OMa YTian RDeng HYang WChen ZYChen X
Theranostics
2020

Yang WZhang FDeng HLin LWang SKang FYu GLau JTian RZhang MWang ZHe LMa YNiu GHu SChen X
ACS Nano
2020 Jan 28


Shan LFan WWang WTang WYang ZWang ZLiu YShen ZDai YCheng SJacobson OZhai KHu JMa YKiesewetter DOGao GChen X
ACS Nano
2019 Aug 27

Tang LYu FTang BYang ZFan WZhang MWang ZJacobson OZhou ZLi LLiu YKiesewetter DOTang WHe LMa YNiu GZhang XChen X
ACS Appl Mater Interfaces
2019 Aug 07

Liu YGong CSLin LZhou ZLiu YYang ZShen ZYu GWang ZWang SMa YFan WHe LNiu GDai YChen X
Theranostics
2019

Zhang MJacobson OKiesewetter DOMa YWang ZLang LTang LKang FDeng HYang WNiu GWang JChen X
Bioconjug Chem
2019 Jun 19

Zhou ZBai RWang ZBryant HLang LMerkle HMunasinghe JTang LTang WTian RYu GMa YNiu GGao JChen X
Bioconjug Chem
2019 Jun 19

Tian RZhu SZeng QLang LMa YKiesewetter DOLiu YFu XLau JZhu GJacobson OWang ZDai YYu GBrooks BRLiu GNiu GChen X
Bioconjug Chem
2019 Jun 19

Wang SWang ZYu GZhou ZJacobson OLiu YMa YZhang FChen ZYChen X
Adv Sci (Weinh)
2019 Mar 06

Tang LYang ZZhou ZMa YKiesewetter DOWang ZFan WZhu SZhang MTian RLang LNiu GZhang XChen X
Theranostics
2019

Wang SYu GMa YYang ZLiu YWang JChen X
ACS Appl Mater Interfaces
2019 Jan 16

Niu GWang GLau JLang LJacobson OMa YKiesewetter DOZhang SChen X
Adv Healthc Mater
2019 Jun


Gu DLazo-Portugal RFang CWang ZMa YKnight MIto Y
J Chromatogr B Analyt Technol Biomed Life Sci
2018 Jun 15

Zhang FNi QJacobson OCheng SLiao AWang ZHe ZYu GSong JMa YNiu GZhang LZhu GChen X
Angew Chem Int Ed Engl
2018 Jun 11

Shan LZhuo XZhang FDai YZhu GYung BCFan WZhai KJacobson OKiesewetter DOMa YGao GChen X
Theranostics
2018

Yang YYang JFang CGu DMa YIto Y
J Chromatogr A
2018 Mar 16

Tian RJacobson ONiu GKiesewetter DOWang ZZhu GMa YLiu GChen X
Theranostics
2018


Zhu GLynn GMJacobson OChen KLiu YZhang HMa YZhang FTian RNi QCheng SWang ZLu NYung BCWang ZLang LFu XJin AWeiss IDVishwasrao HNiu GShroff HKlinman DMSeder RAChen X
Nat Commun
2017 Dec 05

Chen WTian RXu CYung BCWang GLiu YNi QZhang FZhou ZWang JNiu GMa YFu LChen X
Nat Commun
2017 Nov 24

Zhang FZhu GJacobson OLiu YChen KYu GNi QFan JYang ZXu FFu XWang ZMa YNiu GZhao XChen X
ACS Nano
2017 Sep 26

Chen HTong XLang LJacobson OYung BCYang XBai RKiesewetter DOMa YWu HNiu GChen X
Theranostics
2017

Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X
Mol Pharm
2017 Apr 03

Liu YWang SMa YLin JWang HYGu YChen XHuang P
Adv Mater
2017 May


Liu YWang ZZhang HLang LMa YHe QLu NHuang PLiu YSong JLiu ZGao SMa QKiesewetter DOChen X
Nanoscale
2016 May 19

Chen HWang GLang LJacobson OKiesewetter DOLiu YMa YZhang XWu HZhu LNiu GChen X
Theranostics
2016


Liu YWang GZhang HMa YLang LJacobson OKiesewetter DOZhu LGao SMa QChen X
Bioconjug Chem
2016 Jan 20

Fan JHe NHe QLiu YMa YFu XLiu YHuang PChen X
Nanoscale
2015 Dec 21

Rong PHuang PLiu ZLin JJin AMa YNiu GYu LZeng WWang WChen X
Nanoscale
2015 Oct 21

Jacobson OWeiss IDWang LWang ZYang XDewhurst AMa YZhu GNiu GKiesewetter DOVasdev NLiang SHChen X
J Nucl Med
2015 Nov

Jacobson OYan XMa YNiu GKiesewetter DOChen X
Bioconjug Chem
2015 Oct 21


Jacobson OYan XNiu GWeiss IDMa YSzajek LPShen BKiesewetter DOChen X
J Nucl Med
2015 Apr



Yue XWang ZZhu LWang YQian CMa YKiesewetter DONiu GChen X
Mol Pharm
2014 Nov 03

Hu HHuang PWeiss OJYan XYue XZhang MGTang YNie LMa YNiu GWu KChen X
Biomaterials
2014 Dec

Niu GLang LKiesewetter DOMa YSun ZGuo NGuo JWu CChen X
J Nucl Med
2014 Jul


Wang ZYue XWang YQian CHuang PLizak MNiu GWang FRong PKiesewetter DOMa YChen X
Adv Healthc Mater
2014 Aug

Wang FWang ZHida NKiesewetter DOMa YYang KRong PLiang JTian JNiu GChen X
Proc Natl Acad Sci U S A
2014 Apr 08



Zhu LMa YKiesewetter DOWang YLang LLee SNiu GChen X
ACS Chem Biol
2014 Feb 21


Guo JLang LHu SGuo NZhu LSun ZMa YKiesewetter DONiu GXie QChen X
Mol Imaging Biol
2014 Apr


Wang ZZhang XHuang PZhao WLiu DNie LYue XWang SMa YKiesewetter DNiu GChen X
Biomaterials
2013 Aug

Liu DHuang XWang ZJin ASun XZhu LWang FMa YNiu GHight Walker ARChen X
ACS Nano
2013 Jun 25

Zhang XXSun ZGuo JWang ZWu CNiu GMa YKiesewetter DOChen X
Mol Imaging Biol
2013 Dec


Zhang XXWang ZYue XMa YKiesewetter DOChen X
Mol Pharm
2013 May 06

Kiesewetter DOGuo NGuo JGao HZhu LMa YNiu GChen X
Theranostics
2012

Wang ZHuang PBhirde AJin AMa YNiu GNeamati NChen X
Chem Commun (Camb)
2012 Oct 09

Zhu LGuo NLi QMa YJacboson OLee SChoi HSMansfield JRNiu GChen X
Theranostics
2012

Wang HGao HGuo NNiu GMa YKiesewetter DOChen X
Theranostics
2012

Zhu LHuang XChoi KYMa YZhang FLiu GLee SChen X
J Control Release
2012 Oct 10




Kiesewetter DOGao HMa YNiu GQuan QGuo NChen X
Eur J Nucl Med Mol Imaging
2012 Mar

Li WNiu GLang LGuo NMa YKiesewetter DOBacker JMShen BChen X
Eur J Nucl Med Mol Imaging
2012 Feb

Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOPeled AEden HSFarber JMChen X
J Control Release
2012 Jan 30

Zhang FNiu GLin XJacobson OMa YEden HSHe YLu GChen X
Amino Acids
2012 Jun

Chen KSun XNiu GMa YYap LPHui XWu KFan DConti PSChen X
Mol Imaging Biol
2012 Feb


Lang LLi WGuo NMa YZhu LKiesewetter DOShen BNiu GChen X
Bioconjug Chem
2011 Dec 21

Zhu LZhang FMa YLiu GKim KFang XLee SChen X
Mol Pharm
2011 Dec 05

Lang LLi WJia HMFang DCZhang SSun XZhu LMa YShen BKiesewetter DONiu GChen X
Theranostics
2011

Bhattacharjee AKLang LJacobson OShinkre BMa YNiu GTrenkle WCJacobson KAChen XKiesewetter DO
Nucl Med Biol
2011 Aug

Gao HNiu GYang MQuan QMa YMurage ENAhn JMKiesewetter DOChen X
Mol Pharm
2011 Oct 03

Jacobson OWeiss IDSzajek LPNiu GMa YKiesewetter DOFarber JMChen X
Theranostics
2011

Yang MGao HZhou YMa YQuan QLang LChen KNiu GYan YChen X
Theranostics
2011

Zhu LXie JSwierczewska MZhang FQuan QMa YFang XKim KLee SChen X
Theranostics
2011

Jacobson OZhu LMa YWeiss IDSun XNiu GKiesewetter DOChen X
Bioconjug Chem
2011 Mar 16

Lin XXie JZhu LLee SNiu GMa YKim KChen X
Angew Chem Int Ed Engl
2011 Feb 11

Jagoda EMLang LMcCullough KContoreggi CKim BMMa YRice KCSzajek LPEckelman WCKiesewetter DO
Synapse
2011 Sep

Ye YZhu LMa YNiu GChen X
Bioorg Med Chem Lett
2011 Feb 15

Jacobson OZhu LNiu GWeiss IDSzajek LPMa YSun XYan YKiesewetter DOLiu SChen X
Mol Imaging Biol
2011 Dec

Gu DMa YNiu GYan YLang LAisa HAAisaand HAGao HKiesewetter DOChen X
Amino Acids
2011 Feb

Ma ZMa YSun XYe YShen BChen XIto Y
J Chromatogr B Analyt Technol Biomed Life Sci
2010 Nov 01

Sun XNiu GYan YYang MChen KMa YChan NShen BChen X
Clin Cancer Res
2010 Aug 15

Ma YKiesewetter DOLang LGu DChen X
Curr Drug Metab
2010 Jul

Kiesewetter DOKrämer-Marek GMa YCapala J
J Fluor Chem
2008 Sep


Kiesewetter DOLang LMa YBhattacharjee AKGao ZGJoshi BVMelman Ade Castro SJacobson KA
Nucl Med Biol
2009 Jan

Giovacchini GLang LMa YHerscovitch PEckelman WCCarson RE
Neuroimage
2005 Oct 15

Ma YLang LKiesewetter DOVuong BKChanning MIto YEckelman WC
J Chromatogr A
2004 Apr 23

Ma YKiesewetter DLang LEckelman WC
Mol Imaging Biol
2003

Huang BXChanning MAPlascjak PSKiesewetter DODer MMa YEckelman WC
Nucl Med Biol
2003 Oct


Carson REWu YLang LMa YDer MGHerscovitch PEckelman WC
J Cereb Blood Flow Metab
2003 Feb

Kiesewetter DOJagoda EMKao CHMa YRavasi LShimoji KSzajek LPEckelman WC
Nucl Med Biol
2003 Jan