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Mughal - 2026

Mentor: Amreen Mughal Ph.D. | amreen.mughal@nih.gov
Lab
Neurovascular Research (NVR) Unit, NINDS-Stroke Branch

Brain hemodynamics and capillary stall quantifications

Neurovascular Research Unit is part of the NINDS-Stroke Branch. Our lab studies neurovascular coupling mechanisms involved in regulation of blood flow in the brain. We extend this knowledge from basic neurovascular biology to disease models of Vascular Cognitive impairment and Dementia (VCID).

We collect data through multiple imaging modalities including multiphoton microscopy and wide-field imaging to list a few. These imaging sessions are performed in the awake and anaesthetized mouse models with craniotomy implants. We use machine learning and conventional image analysis tools for image processing and quantifying changes in brain blood flow and dissect underlying neurovascular coupling mechanisms. Projects that summer interns will be involved include:

  1. Segmentation of cerebral vasculature data collected from in-vivo multiphoton imaging
  2. Devising machine-learning or conventional approaches for quantification capillary stalls, visualization and characterization of capillary stalls
  3. Developing algorithm to visualize 2D & 4D-data in real-time for multiphoton imaging. 

If you are interested in image analysis, machine learning and coding and brain blood flow, this could be an interesting experience for you.