Repurposed ALS drug becomes imaging probe to help diagnose neurodegeneration

Positron emission tomography (PET) is a nuclear imaging technique used to diagnose conditions such as cancer. An innovative advance from scientists at St. Jude Children’s Research Hospital is enhancing the technique’s ability to check for signs of neurological disease. The researchers repurposed the drug edaravone, an antioxidant used to treat amyotrophic lateral sclerosis (ALS), as a probe to be used with central nervous system PET imaging. With this technique, the researchers can detect oxidative stress, which leads to brain damage, offering a clear path to detecting neurological conditions. Source: St. Jude Children's Research Hospital