Simulating cuts and burns reveals wound healing and clearing power of fibroblasts


NIBIB in the News
March 15, 2023

Therapies that build on the natural tissue clearance by fibroblasts may accelerate healing, especially in slow-to-heal burn wounds.

Researchers create a biomimetic model to study wound healing in burn and laceration wounds. The team designed an in vitro model system made of fibroblasts embedded in a collagen hydrogel. Wounds were created in this microtissue using a microdissection knife to mimic laceration or a high-energy laser to simulate a burn. They discovered that fibroblasts clear away damaged tissue before depositing new material. This part of the healing process is slower in burn wounds. Source: American Institute of Physics/Science Daily