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NIBIB-supported researchers have developed a smart nanoprobe designed to infiltrate prostate tumors and send back a signal using an optical imaging technique known as Raman spectroscopy. The new probe, evaluated in mice, has the potential to determine tumor aggressiveness and could also enable sequential monitoring of tumors during therapy to quickly determine if a treatment strategy is working.

NIBIB is marking the 10-year anniversary of a commercialization program that helps innovators bring their medical devices from the lab to the marketplace.

While pacemakers have treated many patients with heart rhythm disorders, their bulky design and use of wires limits their usefulness and poses a risk of heart damage or infection. Now, researchers have cut the cords, shrunk the size, and expanded the capabilities of current designs.

A team of engineers led by the University of Massachusetts Amherst and including colleagues from the Massachusetts Institute of Technology (MIT) recently announced in the journal Nature Communications that they had successfully built a tissue-like bioelectronic mesh system. The mesh can grow along with the cardiac cells, allowing researchers to observe how the heart's mechanical and electrical functions change during the developmental process.

Source: University of Massachusetts Amherst

Many companies are now developing isothermal genetic tests that can diagnose a wide array of respiratory diseases, sexually transmitted infections and more. These products aim to provide precise and prompt diagnostic information, enabling people to quickly seek appropriate medical treatment. Source: Nature

UMass Chan Medical School researchers have documented a phenomenon that had confounded clinicians: Some people persistently test positive for SARS-CoV-2, the virus that causes COVID-19, on rapid home antigen tests despite obtaining concurrent negative PCR tests. Source: Medical Xpress

A multidisciplinary group of NIH-funded scientists have successfully captured real-time, high-resolution images of the developing mouse placenta during the course of pregnancy. Their technique, which combines a surgically implanted window with a next-generation imaging system, provides key insight into placental development under both healthy and pathological conditions.

After adjusting for multiple comparisons, no differences in MRI measures of brain structureopens in a new tab or window or function emerged between individuals with AHIs and matched controls, reported Carlo Pierpaoli, MD, PhD, of the National Institute of Biomedical Imaging and Bioengineering in Bethesda, Maryland, and co-authors in JAMA.

Source: MedPage Today

Carlo Pierpaoli, lead author on the neuroimaging study, said while there is no evidence of brain injury on the MRIs, it is still possible that those reporting AHIs “may be experiencing the results of an event that led to their symptoms, but the injury did not produce the long-term neuroimaging changes that are typically observed after severe trauma or stroke.”

Source: The Hill