Science Highlights

NIBIB-supported researchers have developed a smart nanoprobe designed to infiltrate prostate tumors and send back a signal using an optical imaging technique known as Raman spectroscopy. The new probe, evaluated in mice, has the potential to determine tumor aggressiveness and could also enable sequential monitoring of tumors during therapy to quickly determine if a treatment strategy is working.

NIBIB is marking the 10-year anniversary of a commercialization program that helps innovators bring their medical devices from the lab to the marketplace.

While pacemakers have treated many patients with heart rhythm disorders, their bulky design and use of wires limits their usefulness and poses a risk of heart damage or infection. Now, researchers have cut the cords, shrunk the size, and expanded the capabilities of current designs.

A multidisciplinary group of NIH-funded scientists have successfully captured real-time, high-resolution images of the developing mouse placenta during the course of pregnancy. Their technique, which combines a surgically implanted window with a next-generation imaging system, provides key insight into placental development under both healthy and pathological conditions.

Researchers at The Pennsylvania State University have developed a new synergistic approach to revascularization that combines a new framework made from granular hydrogels with micropuncture, a surgical technique. Their preclinical method could rapidly grow organized blood vessels in live rats.

Researchers have developed sugar-coated gold nanoparticles to both image and destroy biofilms. In a study, they used the nanoparticles on the teeth and wounded skin of rats and mice, eliminating biofilms in as little as one minute and outperforming common antimicrobials.

In recognition of International Women’s Day (March 8), we’re featuring Rebecca Richards-Kortum, Ph.D., a longtime bioengineer in academia who has contributed globally to improving women's health.

NIH announced finalists in its competition to accelerate development of diagnostic and monitoring technologies to improve fetal health outcomes in low-resource settings.

What if bacteria—which love to grow deep inside tumors—could guide cancer therapies directly to their target? NIH-funded researchers have engineered a bacterial strain to “light up” tumors so that reprogrammed T cells, drawn like a moth to a flame, can find and destroy them. Their preclinical treatment could potentially be effective against any solid tumor type.

The lungs are one of the most difficult organs for physicians to navigate. A collaborative team of NIH-funded researchers have built a compact robotic system that can autonomously steer around anatomical obstacles within the lungs of live animals.