Biomolecular Technologies


This program supports the development and demonstration of broadly applicable biomolecular technologies to enable new paradigms of human health.


The emphasis is on the development of biomolecular technologies and associated computational models for biomedical intervention. 

Projects might focus on:

  • elucidating important engineering design rules or key foundational principles underlying future engineering, including the use of computational methods
  • prototyping or redesigning platform technologies
  • characterizing (in vitro, ex vivo, or in vivo) broadly applicable technologies and prototypes

NIBIB interests include but are not limited to: 

  • molecular switches for synthetic genetic circuits
  • nucleases and genome editors for DNA manipulation and regulation
  • engineered viruses and extracellular vesicles for therapeutic agent delivery
  • transmembrane CARs for extracellular sensing
  • photoactive molecular complexes for optogenetics