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Image-Guided Interventions

This program supports research on the use of novel image-directed technologies for guidance, navigation, tissue differentiation, and disease identification for reaching specified targets during therapeutic procedures, which may range along the continuum from non-invasive to minimally invasive to open surgical interventions. These technologies may range from molecular to macroscopic scale levels.

Emphasis

Overall emphasis is on the engineering of novel image-guided interventions to improve outcomes of interventional procedures. In addition, emphasis includes technologies that expand needed procedural access for individuals otherwise excluded by disease characteristics, co-morbidities, and other parameters.

Additional Emphasis

Image-guided interventions may use supporting technologies relevant to other NIBIB-supported program areas, including but not limited to:

Note that image-guided interventions may support operator-directed, non-robotic procedures as well as robotic procedures.

Areas of priority include development of real-time or near real-time novel image-guided technologies, with robust procedural direction or a robust receiver operating characteristic curve. In addition, cost-efficient technologies, appropriate for low resource settings, and/ or applicable to multiple types of interventions are strongly encouraged.

 
Grant Number Project Title Principal Investigator Institution
5-R01-EB020601-04 A multimodal imaging system and targeted nanoprobes for image-guided treatment of breast cancer Huabei Jiang University of South Florida
5-R01-EB020040-04 Suppression and Analysis of Ultrasonic Clutter During Liver Focal Lesion Biopsy Brett Byram Vanderbilt University
5-R21-EB024771-04 OTOENDOSCOPE PAIRED AGENT IMAGING OF OPIOID RECEPTOR KINETICS DURING DEPENDENCY AND WITHDRAWAL Jonathan Elliott Dartmouth-Hitchcock Clinic
5-K23-EB026507-04 Multimodal Fluorescence- and Imaging-Guided Surgical Navigation: Developing Methods for Subsurface, Indirect Visualization of Cancers Requiring Wide Local Excision Eric Henderson Dartmouth-Hitchcock Clinic
5-K99-EB027177-02 Real-time Non-Rigid 3D Reconstruction and Registration for Laparoscopic-guided Minimally Invasive Liver Surgery Haoyin Zhou Brigham And Women'S Hospital
5-R01-EB025747-04 Image based registration and intraoperative updating for guiding spine surgery Keith Paulsen Dartmouth College
1-R43-EB029804-01A1 Fluorescence Guided Surgery Standardization Tools Ethan Phillip Larochelle Quel Imaging Llc
5-R01-EB020353-04 Theranostic gold nanoparticles for imaged-guided radical prostatectomy and PDT ablation James Basilion Case Western Reserve University
1-R01-EB028792-01 Perioperative Diffuse Optical Imaging of Tissue Blood Flow and Oxygenation for Optimization of Mastectomy Skin Flap Viability Guoqiang Yu University of Kentucky
5-R21-EB027238-03 An Ultra-Thin Molecular Imaging Skin for Intraoperative Imaging of Microscopic Residual Disease in Cancer Mekhail Anwar University of California, San Francisco