Image-Guided Interventions

This program supports research on the use of novel image-directed technologies for guidance, navigation, tissue differentiation, and disease identification for reaching specified targets during therapeutic procedures, which may range along the continuum from non-invasive to minimally invasive to open surgical interventions. These technologies may range from molecular to macroscopic scale levels.


Overall emphasis is on the engineering of novel image-guided interventions to improve outcomes of interventional procedures. In addition, emphasis includes technologies that expand needed procedural access for individuals otherwise excluded by disease characteristics, co-morbidities, and other parameters.

Additional Emphasis

Image-guided interventions may use supporting technologies relevant to other NIBIB-supported program areas, including but not limited to:

Note that image-guided interventions may support operator-directed, non-robotic procedures as well as robotic procedures.

Areas of priority include development of real-time or near real-time novel image-guided technologies, with robust procedural direction or a robust receiver operating characteristic curve. In addition, cost-efficient technologies, appropriate for low resource settings, and/ or applicable to multiple types of interventions are strongly encouraged.

Grant Number Project Title Principal Investigator Institution
5-R01-EB020601-04 A multimodal imaging system and targeted nanoprobes for image-guided treatment of breast cancer Huabei Jiang University of South Florida
5-R01-EB022230-04 Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor. Hak Soo Choi Massachusetts General Hospital
5-K23-EB026507-04 Multimodal Fluorescence- and Imaging-Guided Surgical Navigation: Developing Methods for Subsurface, Indirect Visualization of Cancers Requiring Wide Local Excision Eric Henderson Dartmouth-Hitchcock Clinic
5-R01-EB025747-04 Image based registration and intraoperative updating for guiding spine surgery Keith Paulsen Dartmouth College
1-R43-EB029804-01A1 Fluorescence Guided Surgery Standardization Tools Ethan Phillip Larochelle Quel Imaging Llc
5-R01-EB026094-04 Ultrasound-guided DNA delivery for regenerative medicine Dan Gazit Cedars-Sinai Medical Center
5-R01-EB026207-04 Image-Guided Transcatheter Delivery of Natural Killer Cell Therapy Augmented with IFN-Gamma Eluting Microspheres Dong-Hyun Kim Northwestern University at Chicago
5-R01-EB028778-02 In situ PEDSy and light delivery platform for Intracavitory Photodynamic Therapy Timothy Zhu University of Pennsylvania
5-R21-EB026553-02 Tumor-targeted delivery and cell internalization of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy Wu Liu Stanford University
5-R01-EB027498-03 Deformation Corrected Image Guided Laparoscopic Liver Surgery Michael Miga Vanderbilt University