Image-Guided Interventions

This program supports research on the use of novel image-directed technologies for guidance, navigation, tissue differentiation, and disease identification for reaching specified targets during therapeutic procedures, which may range along the continuum from non-invasive to minimally invasive to open surgical interventions. These technologies may range from molecular to macroscopic scale levels.


Overall emphasis is on the engineering of novel image-guided interventions to improve outcomes of interventional procedures. In addition, emphasis includes technologies that expand needed procedural access for individuals otherwise excluded by disease characteristics, co-morbidities, and other parameters.

Additional Emphasis

Image-guided interventions may use supporting technologies relevant to other NIBIB-supported program areas, including but not limited to:

Note that image-guided interventions may support operator-directed, non-robotic procedures as well as robotic procedures.

Areas of priority include development of real-time or near real-time novel image-guided technologies, with robust procedural direction or a robust receiver operating characteristic curve. In addition, cost-efficient technologies, appropriate for low resource settings, and/ or applicable to multiple types of interventions are strongly encouraged.

Grant Number Project Title Principal Investigator Institution
5-R00-EB018994-05 Coherence-Based Photoacoustic Image Guidance of Transsphenoidal Surgeries Muyinatu Bell Johns Hopkins University
5-R01-EB020353-04 Theranostic gold nanoparticles for imaged-guided radical prostatectomy and PDT ablation James Basilion Case Western Reserve University
5-R21-EB024553-02 Motion Compensated 4D Fluoroscopy And Dynamic Roadmaps For Real Time Device Guidance In Minimally Invasive Liver Procedures Martin Wagner University of Wisconsin-Madison
5-R01-EB020003-04 MRI Compatible Body-Mounted Robot to Streamline Pediatric Shoulder Arthrography Kevin Cleary Children'S Research Institute
5-R01-EB021362-04 NIR Nerve-specific Fluorescent Imaging for Robotic-assisted Radical Prostatectomy Summer Gibbs Oregon Health & Science University
5-P41-EB015898-15 Image Guided Therapy Center Clare Tempany Brigham And Women'S Hospital
5-K23-EB026507-03 Multimodal Fluorescence- and Imaging-Guided Surgical Navigation: Developing Methods for Subsurface, Indirect Visualization of Cancers Requiring Wide Local Excision Eric Henderson Dartmouth-Hitchcock Clinic
5-R01-EB020601-04 A multimodal imaging system and targeted nanoprobes for image-guided treatment of breast cancer Huabei Jiang University of South Florida
5-R01-EB025747-03 Image based registration and intraoperative updating for guiding spine surgery Keith Paulsen Dartmouth College
1-R43-EB029287-01 Next Generation Fluorescence Guided Surgery with the C-MOLECULES System William Ware Doseoptics, Llc