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Image-Guided Interventions

This program supports research on the use of novel image-directed technologies for guidance, navigation, tissue differentiation, and disease identification for reaching specified targets during therapeutic procedures, which may range along the continuum from non-invasive to minimally invasive to open surgical interventions. These technologies may range from molecular to macroscopic scale levels.


Overall emphasis is on the engineering of novel image-guided interventions to improve outcomes of interventional procedures. In addition, emphasis includes technologies that expand needed procedural access for individuals otherwise excluded by disease characteristics, co-morbidities, and other parameters.

Additional Emphasis

Image-guided interventions may use supporting technologies relevant to other NIBIB-supported program areas, including but not limited to:

Note that image-guided interventions may support operator-directed, non-robotic procedures as well as robotic procedures.

Areas of priority include development of real-time or near real-time novel image-guided technologies, with robust procedural direction or a robust receiver operating characteristic curve. In addition, cost-efficient technologies, appropriate for low resource settings, and/ or applicable to multiple types of interventions are strongly encouraged.

Grant Number Project Title Principal Investigator Institution
5-R21-EB024707-02 Development and Pre-Clinical Evaluation of a Robotic System for Supervised Autonomous Tumor Surgery Axel Krieger Univ of Maryland, College Park
5-R01-EB019460-04 EasyVis: laparoscopic surgical visualization through an untethered, panoramic, three-dimensional imaging system Hongrui Jiang University of Wisconsin-Madison
5-R01-EB020029-04 Peri-operative confocal imaging-guided laser ablation of basal cell carcinomas Milind Rajadhyaksha Sloan-Kettering Inst Can Research
5-R01-EB014946-04 Three-Dimensional Image-Guided Development and Optimization of Molecular Regulating Bone Regenerative Scaffolds Yu Chen Univ of Maryland, College Park
5-R01-EB020366-04 Next generation 4D-CBCT for lung cancer radiation therapy Jing Wang Ut Southwestern Medical Center
5-R01-EB018921-04 Multi-Resolution Foveated Laparoscope for Safer Minimally Invasive Surgery Hong Hua University of Arizona
5-R00-EB016971-05 Controlled Delivery and Release of Chemotherapy in Brain Tumors with FUS Konstantinos-Costas Arvanitis Georgia Institute of Technology
1-R21-EB026089-01A1 Molecularly targeted photothermal ablation to enhance the therapeutic efficacy of immunomodulatory therapies in hepatocellular carcinoma Rahul Sheth University of Tx Md Anderson Can Ctr
5-R00-EB018994-05 Coherence-Based Photoacoustic Image Guidance of Transsphenoidal Surgeries Muyinatu Bell Johns Hopkins University
5-R01-EB026094-02 Ultrasound-guided DNA delivery for regenerative medicine Dan Gazit Cedars-Sinai Medical Center