Image-Guided Interventions

This program supports research on the use of novel image-directed technologies for guidance, navigation, tissue differentiation, and disease identification for reaching specified targets during therapeutic procedures, which may range along the continuum from non-invasive to minimally invasive to open surgical interventions. These technologies may range from molecular to macroscopic scale levels.


Overall emphasis is on the engineering of novel image-guided interventions to improve outcomes of interventional procedures. In addition, emphasis includes technologies that expand needed procedural access for individuals otherwise excluded by disease characteristics, co-morbidities, and other parameters.

Additional Emphasis

Image-guided interventions may use supporting technologies relevant to other NIBIB-supported program areas, including but not limited to:

Note that image-guided interventions may support operator-directed, non-robotic procedures as well as robotic procedures.

Areas of priority include development of real-time or near real-time novel image-guided technologies, with robust procedural direction or a robust receiver operating characteristic curve. In addition, cost-efficient technologies, appropriate for low resource settings, and/ or applicable to multiple types of interventions are strongly encouraged.

Grant Number Project Title Principal Investigator Institution
5-R01-EB026094-04 Ultrasound-guided DNA delivery for regenerative medicine Dan Gazit Cedars-Sinai Medical Center
5-R01-EB026207-04 Image-Guided Transcatheter Delivery of Natural Killer Cell Therapy Augmented with IFN-Gamma Eluting Microspheres Dong-Hyun Kim Northwestern University at Chicago
5-K23-EB026507-05 Multimodal Fluorescence- and Imaging-Guided Surgical Navigation: Developing Methods for Subsurface, Indirect Visualization of Cancers Requiring Wide Local Excision Eric Henderson Dartmouth-Hitchcock Clinic
1-R43-EB032676-01 Smart Multi-grid Template for Focal Therapy of Prostate Cancer Jesung Park Physical Sciences, Inc
5-R01-EB016079-08 Optimizing MRI for Radiation Therapy Treatment Planning James Balter University of Michigan at Ann Arbor
1-R01-EB031007-01A1 Advanced C-arm imaging platform for histotripsy treatment of liver tumors Paul Laeseke University of Wisconsin-Madison
5-R01-EB030547-02 Deformable motion compensation for 3D image-guided interventional radiology Alejandro Sisniega Crespo Johns Hopkins University
5-R21-EB027238-03 An Ultra-Thin Molecular Imaging Skin for Intraoperative Imaging of Microscopic Residual Disease in Cancer Mekhail Anwar University of California, San Francisco
5-R01-EB019460-06 EasyVis: Flexible, immersive three-dimensional laparoscopic surgical visualization through multi-camera arrays Hongrui Jiang University of Wisconsin-Madison
5-R21-EB028508-03 Photodynamic Priming for Bidirectional Modulation of Drug Transport Across the Blood-Brain Tumor Barrier Huang Chiao Huang Univ of Maryland, College Park