X-ray, Electron, and Ion Beam

This program supports the research and development of technologies and techniques that create images of internal structures, contrast agents, or molecular probes using x-rays transmitted through the body (CT, mammography) or x-ray stimulation of secondary emissions (x-ray fluorescence tomography).


Emphasis is on: simulation, design and development of new detector systems; new readout methods that enhance the signal quality for x-ray image generation; designs of novel imaging geometries; algorithms that compensate for the physical properties of the detection system to improve the clinical reliability of the image (reconstruction algorithms); and approaches to radiation dose reduction, especially in CT. Of interest are diagnostic image enhancements via photon counting, dual energy, and new applications of cone-beam tomography.


The emphasized topics are meant to lead toward: improved clinical (CT, mammography) cameras or new camera geometries; new signal-processing and image-generation algorithms; corrections for image artifacts for enhanced reliability of clinical images; studies of x-ray physics to estimate absorbed energy of diagnostic scans; and methods of visualizing or measuring therapy doses. Investigating the associated dosimetry estimations help to decrease the risk of diagnostic and therapy techniques.

Additional emphasis

  • improvement in x-ray tube technologies
  • construction of flat panel detector arrays
  • evaluation of new semiconductor detectors and scintillators
  • reconstruction algorithms for CT and cone-beam geometry
  • advances of photon counting or dual energy in CT
  • techniques for improved image spatial resolution and sensitivity
  • investigating x-ray luminescence tomography
  • design and manufacture of x-ray gratings
  • investigating interferometry and (tissue-induced) phase contrast techniques
  • combining modalities for clinically relevant hybrid cameras
  • software algorithms which estimate patient dosimetry

Additional support

  • improvements in digital radiography and digital fluoroscopy
  • novel interaction processing such as those using scattered x-rays
  • developing ion beams for novel clinical applications
  • new diagnostics applied to image-guided therapy and theranostics


Notice of Special Interest in X-ray-based Devices for Trauma Care

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Grant Number Project Title Principal Investigator Institution
5-R01-EB022028-04 Development of a High Sensitivity, X-ray Detector Technology Based on Polycrystalline Mercuric Iodide for Volumetric Breast Imaging Larry Antonuk University of Michigan at Ann Arbor
1-R41-EB029280-01 The Rapid-Production of the High-Performance and Affordable Cadmium Telluride and Cadmium Zinc Telluride for Medical Imaging Applications Benjamin Montag Radiation Detection Technologies, Inc.
5-U01-EB021183-04 One Stop Shop Imaging for Acute Ischemic StrokeTreatment Guang-Hong Chen University of Wisconsin-Madison
1-R43-EB029281-01 Pixelated Scintillators for High Spatial Resolution and High Quantum Efficiency X-RayDetectors Houxun Miao General Optics, Llc
1-R15-EB024283-01A1 Fast and Robust Low-Dose X-Ray CT Image Reconstruction Larry Zeng Weber State University
7-R01-EB020604-04 An Enabling Technology for Preclinical X-Ray Imaging of Biomaterials In-Vivo Mark Anastasio University of Illinois at Urbana-Champaign
5-R01-EB020658-04 Towards in vivo imaging with benchtop x-ray fluorescence computed tomography Sang Cho University of Tx Md Anderson Can Ctr
5-R21-EB028103-02 Enhanced megavoltage imaging for radiotherapy by light-field imaging of scintillators Patrick La Riviere University of Chicago
5-R01-EB026644-02 SWAD: Large-Area Photon Counting X-Ray Imager using Amorphous Selenium Amirhossein Goldan State University New York Stony Brook
5-R01-EB025470-03 Monitoring of fractures with internal fixators using weight-bearing quantitative cone beam CT Wojciech Zbijewski Johns Hopkins University