2013 Design by Biomedical Undergraduate Teams (DEBUT) Challenge Winners

Category: Diagnostic Devices/Methods, First Prize: $10,000

A photo of a microscope with a bright light coming from the bottom of it. Attached to the slide are multiple red wires attached to syringes.

Personalized Monitoring of Enzyme Dynamics (P-MED), University of California Los Angeles

Jaideep Dudani, Derek Go, Ankit Gupta, Gayane Kocharyan, Roxanne Loo, and Nova Wang 

P-MED focuses on increasing the ability of doctors to personalize cancer treatments by testing how an individual patient will respond to treatment before starting chemotherapy. P-MED consolidated many forms of technology to create a single device that is able to quickly and automatically measure the enzymatic activity in response to prodrugs, (inactive drugs that, when administered, become active through the metabolic processes of the body). The device could potentially help doctors determine the type of drug and dosages for a specific patient without the need to wait and see how the patient responds to treatment.

P-MED Project.pdf

Watch a video from the P-MED team

Category: Therapeutic Devices/Methods, First Prize: $10,000

A photo of the microflora refinement system, a white circle with three tubes with red caps attached to the bottom.

Microflora Refinement System, Dartmouth College

Alison Stace-Naughton, Pauline Schmit, Laura Taylor Gray, and Jen Freise

The Microflora Refinement System helps treat Clostridium difficile (C. diff), an infectious intestinal bacterium. C. diff is the number one cause of hospital-acquired diarrhea and can be highly drug resistant, virulent and deadly. The current treatment for this kind of infection is antibiotics, but they are often ineffective. Recently, fecal microbiota transplantation has been proposed as an effective alternative, but the treatment has not gained popularity due to the “ick” factor that comes from having to process the donor feces used to repopulate the gut microflora in the infected patient. The Microflora Refinement System designed by this team automates the process of separating the beneficial microbiota from the fecal matter and could potentially make transplantation more widely available. 

Microflora Refinement System Project.pdf
Watch a video from the MIcroflora Refinement team

Category: Technology to Aid Underserved Populations and Individuals with Disabilities, First Prize: $10,000

A photo of an IV bag with its cord slightly bent attached to the IV DRIP system, a metal device that is attached to both the top and bottom of the bag.

IV DRIP: Accurate, Low-cost, Mechanical Device to Regulate Intravenous (IV) Fluid Delivery for Children in the Developing World, Rice University

Bailey Flynn, Matthew Nojoomi, Michael Pan, Kamal Shah, and Erica Skerrett

The IV DRIP addresses the dangerous problem of over-hydration when treating dehydrated children and elderly patients with IVs. Many clinics worldwide are understaffed and cannot closely monitor a patient’s fluid intake. Infusion pumps that regulate the maximum volume of fluids in an IV, as often found in the US, cost between $1,000 and $3,500. IV DRIP is a mechanical, weight-based device that is able to regulate the volume of fluids given to the patient and costs only $80. While the design and construction are surprisingly simple, the project will eliminate the possibility of over-hydration in at-risk patients in an affordable way without placing additional burdens on hospital staff. 

IV DRIP Project.pdf

Watch a video from the IV DRIP team

Honorable Mentions

Category of Diagnostic Devices/Methods

Ballpoint Laparoscope: University of California Berkeley, Neil Ray, Sakthivel Nagaraj, Jeffrey Yang, Nasim Barzanian

Ballpoint Laparoscope Project.pdf
Watch a video from the Ballpoint Laparoscope team

Handy Gym: Upper Limb Assessment Device: University of Michigan, Ryan Frisbie, Tyler Bitterman, Adam Naylor, and Kody Young

Handy Gym Project.pdf
Category of Therapeutic Devices/Methods

ChemoPatch: A Next-Generation Cancer Chemotherapy Device: University of Pennsylvania: Nikhil Mehandru, Aaron Perez, Brandon Sim, and Alydaar Rangwala

ChemoPatch Project.pdf
Watch a video from the ChemoPatch team

ChitO2-Clot: New Jersey’s Science and Technology University, George Ulsh, Dung Le, Jennifer Moy, Maxwell McDermott

Chit02-Clot Project.pdf
Watch a video from the Chit02-Clot team

Category of Technology to Aid Underserved Populations and Individuals with Disabilities

Titan: A Powered Upper Body Exoskeleton: University of Pennsylvania, Nicholas McGill, Elizabeth Beattie, Nicholas Parrotta, and Nikolay Vladimirov 

Titan Project.pdf
Watch a video from the Titan team

An Integrated Microfluidic System for Sample Concentration and Extraction: Boston University, Rebecca LaCroix, Michelle Wong, Justine Lo, and Gabriella Stueber

An Integrated Microfluidic System Project.pdf

NIH DEBUT Press Release

Distinguished Achievement and NIBIB Lecture/DEBUT Awards Ceremony

Friday, September 27, 2013
10:30am – 12:00pm
Biomedical Engineering Society Conference
Washington State Convention Center, 6E