2020 Design by Biomedical Undergraduate Teams (DEBUT) Challenge Winners

Image of the Onchoscope with a hand under the lens.Steven H. Krosnick (First) Prize: The Onchoscope, Stanford University

Clay Ellington, Claire Lamadrid, Marissa MacAvoy, Julia Schaepe, Kelsie Wysong

A low-cost microscope that could help diagnose Onchocerciasis, often called river blindness, a parasitic disease that causes extreme itchiness and, eventually, blindness. It affects more than 20 million people worldwide. The Onchoscope has the ability to diagnose the disease more accurately than the current standard of care and can also be used to monitor the parasitic load over time to evaluate the effectiveness of treatment.

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Diagram of the osmotic concentrator with each individual component seperated out.Second Place: Osmotic concentrator to diagnose tuberculosis, University of Washington, Seattle

Samuel (Sheng-You) Chen, Ruby Lunde, Abe (Yuan-Che) Wu

Confirming a TB diagnosis involves invasive sputum samples, which can be difficult for children and people who are immunocompromised. A urine-based test would be both cheaper and easier to collect. However, because urine is 95% water, there are currently no tests that are sensitive enough to accurately diagnose TB. This new device concentrates urine so that the biomarkers can be detected by lateral flow strip tests.

Image of a silo in use, containing an infants intestines until they can be put back into the abdomen.Third Place: Low-cost Silo for gastroschisis, Duke University

Muthu Arivoli, Arushi Biswas, Nolan Burroughs, Caroline Salzman, Patrick Wilson

This low-cost silo can be used to help save the lives of infants in Sub-Saharan Africa who suffer from gastroschisis, a birth defect where the bowel develops outside the baby’s body. The silo is a plastic bag with a semi-rigid opening that is used to protect and contain the baby’s internal organs until they can be reintroduced into the abdomen. Children in high income countries who suffer from gastroschisis have a survival rate of more than 95%. However, babies in Sub-Saharan Africa have a survival rate of less than 10%. This is often because they do not have a dedicated silo for the intestines and instead end up using an intravenous fluid bag or even an examination glove. The device is an affordable alternative that costs less than five dollars and could help drastically increase the survival of children suffering from gastroschisis.

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Image of the Cytoscope with a tablet at the center of it.HIV/AIDS Prize: CytoScope: The Future of HIV Monitoring, Johns Hopkins University

Nathan Riemann, Alexandra Szewc, Jerry Zhang

The CytoScope is a low-cost microscope that is able to quickly analyze blood samples to monitor the progression of HIV and warn the patient if the disease has progressed. The relatively low cost of this microscope could help expand the monitoring of HIV/AIDS, especially in low income areas.

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A silver rendering of the At Your Cervix design and a photo of the prototype, a rectangular shape with multiple holes in it.

Healthcare Technologies for Low-Resource Settings Prize: Universal Obturator for Brachytherapy, Rice University

Elisa Arango, Susannah Dittma, Krithika Kumar, Lauren Payne, Sanika Rane

This is a low-cost 3D printed device that could help expand treatment of late-stage cervical cancer in areas where medical providers do not have the training or expertise to administer brachytherapy (radioactive implants).

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Diagram of how the NeuroTrack should work, collecting data on the seizures in real time and providing the data to the doctors.VentureWell Venture Prize: NeuroTrak, Columbia University

Brandon Cuevas, Abhinav Kurada, Panagiotis Oikonomou, Juan Rodriguez

The NeuroTrak is designed to consistently collect electroencephalography (EEG) data in real time to monitor Focal with Impaired Awareness (FIA) seizures. It can increase the accuracy of seizure information over self-reported data and can help doctors make more informed treatment decisions.

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Picture of first-generation prototype of the NephrogenVentureWell Design Excellence Prize: Nephrogen, Standford University

Bowen Jiang, Myles O'Leary, Demetri Maxim

Nephrogen is a urine dipstick test to detect acute kidney injuries. Early detection of kidney injury from conditions such as drug-induced nephrotoxicity, septic shock, or dehydration can increase the odds of survival up to five times. This test is a quick, low-cost way to screen for kidney injuries, especially in low-income environments where there may not be adequate testing resources.

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Honorable Mentions:

SipClip: An Assistive Dental Device for People with Dysphagia, Duke University

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ViveSense, Columbia University

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PneuMed: Bacterial Monitor for Life-Support Patients, Detection of Ventilator-Associated Pneumonia, The University of Texas at San Antonio

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EdgeSense: Fiducial Marker to Improve Postoperative Radiation Therapy, Johns Hopkins University

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CranioGrip, Clemson University

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