Peter W Schuck

Peter W Schuck
Peter
Schuck
Investigator

BG 13 RM 3W56 13 SOUTH DR BETHESDA MD 20814

Biography

Dr. Schuck obtained his Ph.D. from the Goethe-University Frankfurt in Main, Germany, where he worked on interactions of integral proteins of the erythrocyte membrane using analytical ultracentrifugation. He received his post-doctoral research training in physical biochemistry with Dr. Allen Minton at NIDDK, and joined the Bioengineering and Physical Science Program of NCRR as a Research Fellow in 1997, developing biophysical methods for the study of protein interactions. In 2014 he was appointed an Earl Stadtman Investigator in NIBIB and Chief of the Dynamics of Macromolecular Assembly Section in the Laboratory of Cellular Imaging and Macromolecular Biophysics.

Research Interests

The Section of the Dynamics of Macromolecular Assembly develops biophysical methods to study protein interactions and the assembly of multi-protein complexes. Hallmarks of multi-protein complexes are multi-valent interactions and cooperativity. In the molecular machinery of cellular processes these constitute ubiquitous mechanisms for the integration and transfer of information.  Therefore, our focus is on the development of approaches for multi-component systems where several different macromolecular components interact to allow association and dissociation of different co-existing complexes in different states.  We are interested in the characterization of the number of assembly states, and their size, shape, and the interaction energetics. Complementary to crystallographic techniques, such solution interaction studies can provide information on the assembly principles of structurally polymorph multi-protein complexes. 

Our group has been particularly active in the development of quantitative hydrodynamic methods using sedimentation velocity analytical ultracentrifugation in conjunction with mathematical modeling of reaction/diffusion/sedimentation processes. We have recently embarked on the development of novel fluorescence detection approaches, which allow unprecedented sensitivity and resolution. We are also pursuing other techniques, including optical biosensing, isothermal titration calorimetry and global multi-method modeling approaches. We are dedicated to the dissemination of methodology, and have implemented our computational analysis methods in widely used software.  

We are involved in several collaborative applications in various fields including immunological protein complexes, viral proteins, membrane receptor complexes, and eye lens crystallins.

 

Publications


Olugbile SVillard VBertholet SJafarshad AKulangara CRoussilhon CFrank GAgak GWFelger INebie IKonate KKajava AVSchuck PDruilhe PSpertini FCorradin G
Vaccine
2011 Sep 16


Zhao HBrown PHMagone MTSchuck P
J. Mol. Biol.
2011 Aug 19

Seok TJJamshidi AKim MDhuey SLakhani AChoo HSchuck PJCabrini SSchwartzberg AMBokor JYablonovitch EWu MC
Nano Lett.
2011 Jul 13


Zhao HBrown PHSchuck P
Biophys. J.
2011 May 04





Potty ASKourentzi KFang HSchuck PWillson RC
Int. J. Biol. Macromol.
2011 Apr 01



Chaudhry CPlested AJSchuck PMayer ML
Proc. Natl. Acad. Sci. U.S.A.
2009 Jul 28

Jamshidi ANeale SLYu KPauzauskie PJSchuck PJValley JKHsu HYOhta ATWu MC
Nano Lett.
2009 Aug


Kumar JSchuck PJin RMayer ML
Nat. Struct. Mol. Biol.
2009 Jun

Gondeau CCorradin GHeitz FLe Peuch CBalbo ASchuck PKajava AV
Mol. Biochem. Parasitol.
2009 Jun

Chaudhry CWeston MCSchuck PRosenmund CMayer ML
EMBO J.
2009 May 20

Jian XBrown PSchuck PGruschus JMBalbo AHinshaw JERandazzo PA
J. Biol. Chem.
2009 Jan 16




Goncalvez APChien CHTubthong KGorshkova IRoll CDonau OSchuck PYoksan SWang SDPurcell RHLai CJ
J. Virol.
2008 Jul

Binger KJPham CLWilson LMBailey MFLawrence LJSchuck PHowlett GJ
J. Mol. Biol.
2008 Feb 29


Gohon YDahmane TRuigrok RWSchuck PCharvolin DRappaport FTimmins PEngelman DMTribet CPopot JLEbel C
Biophys. J.
2008 May 01

Lengyel JSStott KMWu XBrooks BRBalbo ASchuck PPerham RNSubramaniam SMilne JL
Structure
2008 Jan

Balbo ABrown PHBraswell EHSchuck P
Curr Protoc Immunol
2007 Nov


Mans JNatarajan KBalbo ASchuck PEikel DHess SRobinson HSimic HJonjic STiemessen CTMargulies DH
J. Biol. Chem.
2007 Nov 30

Chen ZEarl PAmerico JDamon ISmith SKYu FSebrell AEmerson SCohen GEisenberg RJGorshkova ISchuck PSatterfield WMoss BPurcell R
J. Virol.
2007 Sep


Boukari HSackett DLSchuck PNossal RJ
Biopolymers
2007

Fernández MMBhattacharya SDe Marzi MCBrown PHKerzic MSchuck PMariuzza RAMalchiodi EL
Proteins
2007 Jul 01



Schuck PBoyd LFAndersen PS
Curr Protoc Cell Biol
2004 May

Schuck Pvan den Ameele HJaanson PRyckmans VHawley C
CNS Drugs
2004

Gonzales NRPadlan EADe Pascalis RSchuck PSchlom JKashmiri SV
Mol. Immunol.
2004 Jul




Houtman JCHigashimoto YDimasi NCho SYamaguchi HBowden BRegan CMalchiodi ELMariuzza RSchuck PAppella ESamelson LE
Biochemistry
2004 Apr 13




Weston MCSchuck PGhosal ARosenmund CMayer ML
Nat. Struct. Mol. Biol.
2006 Dec

Houtman JCYamaguchi HBarda-Saad MBraiman ABowden BAppella ESchuck PSamelson LE
Nat. Struct. Mol. Biol.
2006 Sep



Garcia ADOtero JLebowitz JSchuck PMoss B
J. Biol. Chem.
2006 Apr 28


Chen ZMoayeri MZhou YHLeppla SEmerson SSebrell AYu FSvitel JSchuck PSt Claire MPurcell R
J. Infect. Dis.
2006 Mar 01

Chen ZEarl PAmerico JDamon ISmith SKZhou YHYu FSebrell AEmerson SCohen GEisenberg RJSvitel JSchuck PSatterfield WMoss BPurcell R
Proc. Natl. Acad. Sci. U.S.A.
2006 Feb 07



Che MMBoja ESYoon HYGruschus JJaffe HStauffer SSchuck PFales HMRandazzo PA
Cell. Signal.
2005 Oct


Minor KHSchar CRBlouse GEShore JDLawrence DASchuck PPeterson CB
J. Biol. Chem.
2005 Aug 05



Gaidamakov SAGorshkova IISchuck PSteinbach PJYamada HCrouch RJCerritelli SM
Nucleic Acids Res.
2005


González JMVélez MJiménez MAlfonso CSchuck PMingorance JVicente MMinton APRivas G
Proc. Natl. Acad. Sci. U.S.A.
2005 Feb 08

Gupta NArthos JKhazanie PSteenbeke TDCensoplano NMChung EACruz CCChaikin MADaucher MKottilil SMavilio DSchuck PSun PDRabin RLRadaev SVan Ryk DCicala CFauci AS
Virology
2005 Feb 20

Vorup-Jensen TCarman CVShimaoka MSchuck PSvitel JSpringer TA
Proc. Natl. Acad. Sci. U.S.A.
2005 Feb 01

Balbo AMinor KHVelikovsky CAMariuzza RAPeterson CBSchuck P
Proc. Natl. Acad. Sci. U.S.A.
2005 Jan 04


Dam JGuan RNatarajan KDimasi NChlewicki LKKranz DMSchuck PMargulies DHMariuzza RA
Nat. Immunol.
2003 Dec

Gonzales NRPadlan EADe Pascalis RSchuck PSchlom JKashmiri SV
Mol. Immunol.
2003 Oct

Ali SAIwabuchi NMatsui THirota KKidokoro SArai MKuwajima KSchuck PArisaka F
Biophys. J.
2003 Oct





Andersen JFFrancischetti IMValenzuela JGSchuck PRibeiro JM
J. Biol. Chem.
2003 Feb 14





Schuck P
Lancet
2002 Jul 20



Andersen PSSchuck PSundberg EJGeisler CKarjalainen KMariuzza RA
Biochemistry
2002 Apr 23


Arthos JCicala CSteenbeke TDChun TWDela Cruz CHanback DBKhazanie PNam DSchuck PSelig SMVan Ryk DChaikin MAFauci AS
J. Biol. Chem.
2002 Mar 29