Creating Biomedical Technologies to Improve Health

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Grantee News • January 9, 2018

A new blood stabilization method significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor cells, living cancer cells carried in the bloodstream. Read more at ScienceNewsline.

Grantee News • January 8, 2018

A new system designed to study how cavitation bubbles created by ultrasound therapy affect nearby cells shows that attaching microbeads to the cellular membrane could make techniques like sonogenetics or ultrasonic modulation safer and more effective. Read more from Duke University Pratt School of Engineering. 

Grantee News • January 8, 2018

Scientists have designed bacteria to reflect sound waves like submarines. The technology could eventually allow doctors to image therapeutic bacteria in the body using ultrasound. Read more at Caltech News.

Science Highlights • December 22, 2017
NIH researchers have devised a biochemically formulated patch of dissolvable microneedles for the treatment of type 2 diabetes. The biochemical formula of mineralized compounds in the patch responds to blood chemistry to manage glucose automatically. In a proof-of-concept study performed with mice, the researchers showed that the chemicals interact in the bloodstream to regulate blood sugar for days at a time.
Grantee News • December 20, 2017

A study activated genes in human stem cells that initiate biomineralization, a key step in bone formation, according to a science team. Scientists engineered spider web silk combined with silica to activate cell membrane protein receptor integrin. The research will help scientists model intracellular pathways that govern bone formation and efforts to cure diseases such as osteoporosis and calcific aortic valve disease. Read more from the Texas Advanced Computing Center.

Grantee News • December 15, 2017

Scientists have invented a major new advance in DNA nanotechnology. Dubbed 'single-stranded origami,' their new strategy uses one long, thin noodle-like strand of DNA, or its chemical cousin RNA, that can self-fold -- without even a single knot -- into the largest, most complex structures to date. The strands forming these structures can be made inside living cells, opening up the potential for nanomedicine. Read more form Arizona State University.

Grantee News • December 14, 2017

Scientists have adapted DNA-PAINT technology to microscopes that are widespread among cell biology laboratories, called confocal microscopes, and that are used by researchers to image whole cells and thicker tissues at lower resolution. They have demonstrated that the method can visualize a variety of different molecules, including combinations of different proteins, RNAs and DNA throughout the entire depth of whole cells at super-resolution. Read more at the Harvard Wyss Institute.

Grantee News • December 14, 2017

Much as a frame provides structural support for a house and the chassis provides strength and shape for a car, a team of engineers believes they have a way to create the structural framework for growing living tissue using an off-the-shelf 3-D printer. Read more at Penn State News.

Grantee News • December 14, 2017

Cancer imaging can be simplified by a photonic process utilizing molecules derived from horse chestnuts, research shows. Read more at Phys.Org.

Grantee News • December 14, 2017

Using light-emitting nanoparticles, scientists have invented a highly effective method to detect tiny tumors and track their spread, potentially leading to earlier cancer detection and more precise treatment. The technology could improve patient cure rates and survival times. Read more at Medical NewsToday.

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