Creating Biomedical Technologies to Improve Health


Division of Applied Science & Technology (DAST)

The focus of the division is to support the development of innovative biomedical imaging technologies that are low cost and accessible, transform our understanding of biological and disease processes, and enable patient centered healthcare.

  • 4D Nucleome - The 4D Nucleome program, an NIH Common Fund initiative, aims to understand the organization of the cell nucleus in 3D space, as well as in time—the 4th dimension. The 4D Nucleome program includes an interdisciplinary consortium to explore nuclear organization and function; the development of new chemical, biochemical, and imaging tools; the study of structural and functional subregions within the nucleus; an organizational hub to facilitate collaboration and resource sharing; and a center to coordinate and integrate data generated by the 4D Nucleome investigators. NIBIB is one of five NIH institutes that administer the 4D Nucleome program. Read more at the NIH Comon Fund. (Richard Conroy,
  • Single Cell Analysis – As part of a trans-NIH Common Fund Program, this area involves the development of innovative tools and techniques for high throughput, high content imaging of cells in situ to identify and measure cellular heterogeneity, emergent properties in subpopulations, rare cell types and response of complex environments to therapies. It also includes the development of new methods for integrating genomic, metabolomic, proteomic and imaging data to identify imaging biomarkers, multi-scale imaging which links cellular characteristics to organ function and novel approaches for distinguishing relevant signal from biological and technical “noise”. (Richard Conroy,
  • Human Connectome Project (HCP) – The HCP involves 16 NIH institutes and centers and is part of the NIH Blueprint for Neuroscience Research ( The HCP supports research that uses cutting-edge imaging technologies to map the circuitry involved in brain function in healthy humans. (Guoying Liu,
  • Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative – The BRAIN Initiative is a Presidential project aimed at revolutionizing our understanding of the human brain. The goal is to map circuits of the brain, measure fluctuating patterns of electrical and chemical activity flowing within those circuits, and understand how their interplay creates our unique cognitive and behavioral capabilities. By accelerating the development and application of innovative technologies, researchers will be able to produce a dynamic picture of the brain that, for the first time, shows how individual cells and complex neural circuits interact in both time and space. It is expected that the application of these new tools and technologies will lead to new ways to treat, cure, and even prevent brain disorders. NIH is one of several federal agencies involved in this initiative. For more information: (Guoying Liu,