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Point of Care Technologies - Diagnostics

This program supports the technology development of rapid in-vitro diagnostic technologies and monitoring platforms that provide real time medical evaluation and analysis of the disease status or condition at the time and place of patient care.

Emphasis

The program includes the delivery of healthcare that is safe, effective, timely, patient-centered, efficient, and available in centralized and decentralized locations. The emphasis is on developing technologies driven by clinical needs. Examples of technology development areas in this program include but are not limited to disposable lateral flow assays, nucleic acid testing platforms, glucose monitoring devices, etc.

Program priorities

  • Rapid: ideal diagnostic test time suitable for identification of species and determination of susceptibility profiles, including the time required to process the clinical sample (if appropriate) through detection and delivery of the final test result during a single interaction
  • Sensitive: sensitivity should be equivalent to or exceed current standards for proposed targets from the same sample type
  • Specific: specificity should be equivalent to or exceed current standards for proposed targets from the same sample type
  • Easy-to-use: integrated, closed sample-to-answer system with automated data analyses and/or result presentation and with minimal operator training and expertise required
  • Cost-effective: projected production and operating costs should be consistent or an improvement on commonly used platforms

Featured programs and resources

  • Point of Care Technology Research Network

NIBIB created the Point-of-Care Technologies Research Network (POCTRN) to drive the development of appropriate point-of-care diagnostic technologies through collaborative efforts that merge scientific and technological capabilities with clinical need. Today, with the support of the National Heart, Lung and Blood Institution, National Institute of Allergy and Infectious Diseases, National Center for Complementary and Integrative Health, Fogarty International Center, Office of Behavioral and Social Sciences Research, Office of AIDS Research and Office of Disease Prevention, the following Centers comprise POCTRN.

  • Point of Care Technology Research Network Center- Coordinating Center
  • Center for Point-of-Care Technologies Research for Sexually Transmitted Diseases
  • The Center for Innovation in Point of Care Technologies for HIV/AIDS at Northwestern (C-THAN)
  • Atlanta Center for Microsystems Engineered Point-of-Care Technologies (ACME-POCT)
  • The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep Diseases

Visit www.poctrn.org for detailed information.

Active Point of Care Technology Projects at NIH (data as of 09-19-2019)

Explore all actively funded NIH Projects on point of care technologies - technologies that bring care to the patient, rather than take the patient to care.  This broadly inclusive Trans-NIH database uses NIH Research Portfolio Online Reporting Tools (RePORT) to quickly search projects, publications, patents, clinical studies, data and visualizations, news and more.  Please contact Dr. Rishi A. Mathura (rishi.mathura@nih.gov) with questions or comments.

  • Point of Care Technology listserv

The e-newsletter serves as an information outlet to the Point of Care Technology community on current activities and initiatives involving point of care technology research supported by the National Institutes of Health. Join the NIBIB Point of Care Technologies listserv.

Notice of Special Interest in Physiological Monitoring and Point of Care Technologies for Trauma Care

Register for program related webinars here.

 
Grant Number Project Title Principal Investigator Institution
5-R01-EB021150-04 Digital LAMP as a point of care assay for HPV detection Daniel Chiu University of Washington
5-R01-EB023607-04 A Reaction- Diffusion-Based Approach for Nucleic Acid Quantification Changchun Liu University of Connecticut Sch of Med/Dnt
5-R21-EB025499-02 Detection of early-stage, active tuberculosis infection and disease progression during treatment using a rapid, inexpensive and simple-to-use microneedle patch diagnostic platform Mark Prausnitz Georgia Institute of Technology
5-R25-EB025788-02 Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom Jonathan Rosen Boston University (Charles River Campus)
5-U54-EB015408-07 Point of Care Technology Research Center in Primary Care John Parrish Massachusetts General Hospital
5-U54-EB007958-12 Center for Point-of-Care Technologies Research for Sexually Transmitted Diseases Yukari Manabe Johns Hopkins University
5-R01-EB022630-03 Electrokinetic paper diagnostic platform: 15-minute, quantitative nucleic acid amplification for viral pathogens in whole blood Jonathan Posner University of Washington
5-U54-EB027049-02 The Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University (C-THAN) Robert Murphy Northwestern University
5-R25-EB025792-02 Development of a comprehensive biodesign curriculum to promote biomedical innovation Wei Yin State University New York Stony Brook
1-R21-EB028485-01 Point-of-Care Quantitation of Sputum Neutrophil Elastase Activity in Chronic Airway Disease Anthony O'Donoghue University of California, San Diego