Bioanalytical Sensors

Bioanalytical Sensors program supports the development of sensor technologies for the detection and quantitation of clinically relevant analytes in complex matrices for use in biomedical applications.


Emphasis is on engineering the components and functionality of bioanalytical sensors. Detection could be based on optical, chemical, electrochemical, and/or physical (such as mechanical, gravimetric, thermal) perturbation of a sample, for example. Examples of technologies of interest include, but are not limited to:

  • nano-textured substrates for analyte detection
  • DNA sensors for liquid biopsy
  • small molecule detectors for diagnosing infectious diseases.


The development of biomedical devices that use bioanalytical sensors is supported by the NIBIB Point of Care Technologies program. The development of imaging probes is supported by the NIBIB Molecular Probes and Imaging Agents program. 

Grant Number Project Title Principal Investigator Institution
5-R01-EB022025-04 Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndrome Nicholas Peppas University of Texas, Austin
5-R44-EB023750-03 Tools for the site-specific labeling and immobilization of antibodies for immunoassays Feifan Yu Alphathera, Inc.
5-R01-EB012135-10 Phi29 motor nanopore for single molecule sensing Peixuan Guo Ohio State University
5-R01-EB024989-04 Mechanical Phenotyping of Random Periaerolar Fine Needle Aspiration-Collected Cells for Early Breast Cancer Detection Lydia Sohn University of California Berkeley
5-R03-EB028043-02 A user-friendly microchip for rapid optimization of protein conjugation reactions Rebecca Pompano University of Virginia
5-R01-EB003320-24 In vivo chemical monitoring using capillary separations Robert Kennedy University of Michigan at Ann Arbor
5-R21-EB024623-03 Phage-Enabled Lab-on-a-Filter for Pathogen Separation, Concentration, and Detection Sam Nugen Cornell University
1-R01-EB029795-01 Novel Biosensors based on Mining Bacterial Transcription Factors James Galagan Boston University (Charles River Campus)
5-R01-EB022592-04 Synthetic biology-based detection of micronutrients with minimal equipment Mark Styczynski Georgia Institute of Technology
5-R03-EB028869-02 Metal-organic Framework Encapsulation of Biomolecules for Ultra-stable Diagnostic Assays and Sensors in Resource-limited Settings Congzhou Wang South Dakota School of Mines And Techn'Y