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Biosensors and Physiological Detectors

This program supports the development of sensor technologies for the detection and quantitation of clinically relevant analytes in complex matrices for use in a spectrum of diagnostic, therapeutic, imaging, and other biomedical applications.


Emphasis is on engineering the functionality of biosensors and physiological detectors. Function could be based on optical, chemical, electrochemical, physical (such as mechanical, gravimetric, thermal), and/or biological detection, for example.

Additional emphasis

The biosensors and physiological detectors may be engineered to further enable technologies that are relevant to NIBIB-supported program areas, including but not limited to:

Furthermore, this program supports the development of analytical tools to interrogate biosensors and physiological detectors as related to their design, development, and initial validation.


The development of biomedical devices that use biosensors and physiological detectors is supported by the NIBIB Point of Care Technologies, Therapeutic Devices, and Surgical Tools programs. The development of imaging probes is supported by the NIBIB Molecular Imaging program.

More information on the Innovations in Technologies to Enhance the Golden Hour workshop can be found here

Notice of Special Interest in Physiological Monitoring and Point of Care Technologies for Trauma Care

Register for program related webinars here.

Grant Number Project Title Principal Investigator Institution
1-U01-EB021923-01 Development of the Total Exposure Monitoring Unit (TEMU) for Pediatric Asthma Edmund Seto University of Washington
1-U01-EB021952-01 A wearable asthma trigger monitoring system with integrated physiological monitor Yordan Kostov University of Maryland Balt Co Campus
1-U01-EB021980-01 A personal exposure and response monitoring system for pediatric asthma study Nongjian Tao Arizona State University-Tempe Campus
1-U01-EB021983-01 Monitoring Particulate, PAH, Allergen and Microbial Exposures in Asthmatic Kids Steven Chillrud Columbia Univ New York Morningside
1-U01-EB021986-01 Ambulatory Sensor Arrays for Real-Life Monitoring of Pediatric Patients with Asthma Zhenyu Li George Washington University
1-U01-EB022003-01 A wearable monitor for pediatric asthma: Developing environmental and breath sensors linked to spirometry Cristina Davis University of California at Davis
5-R21-EB024120-02 Solid-State Nanopores integrated with Nanoporous Membranes for enhanced Single-Molecule Counting of low-abundance Biomarkers James Mcgrath University of Rochester
5-R21-EB024116-02 Polarization-Activated Droplet Sorting Brian Paegel Scripps Florida
5-R21-EB024101-02 Microfluidic Integrative Circulating miRNA Profiling for Cancer Diagnosis Yong Zeng University of Kansas Lawrence
1-DP2-EB022358-01 Stretchable, Biodegradable, and Self-Healing Semiconductors for Wearable and Implantable Sensors Darren Lipomi University of California, San Diego