Bioanalytical Sensors

Bioanalytical Sensors program supports the development of sensor technologies for the detection and quantitation of clinically relevant analytes in complex matrices for use in biomedical applications.


Emphasis is on engineering the components and functionality of bioanalytical sensors. Detection could be based on optical, chemical, electrochemical, and/or physical (such as mechanical, gravimetric, thermal) perturbation of a sample, for example. Examples of technologies of interest include, but are not limited to:

  • nano-textured substrates for analyte detection
  • DNA sensors for liquid biopsy
  • small molecule detectors for diagnosing infectious diseases.


The development of biomedical devices that use bioanalytical sensors is supported by the NIBIB Point of Care Technologies program. The development of imaging probes is supported by the NIBIB Molecular Probes and Imaging Agents program. 

Grant Number Project Title Principal Investigator Institution
5-R01-EB022025-04 Sensor arrays based on molecularly imprinted polymers for diagnosis of Sjogren's syndrome Nicholas Peppas University of Texas at Austin
5-R44-EB023750-03 Tools for the site-specific labeling and immobilization of antibodies for immunoassays Feifan Yu Alphathera, Inc.
5-R01-EB022592-04 Synthetic biology-based detection of micronutrients with minimal equipment Mark Styczynski Georgia Institute of Technology
5-K99-EB025254-02 High-throughput micro-RNA profiling of single cells and its application in leukemia Suman Bose Massachusetts Institute of Technology
5-R03-EB028869-02 Metal-organic Framework Encapsulation of Biomolecules for Ultra-stable Diagnostic Assays and Sensors in Resource-limited Settings Congzhou Wang South Dakota School of Mines And Techn'Y
5-R21-EB028958-02 Single-molecule counting of circular RNAs using phage nanoparticles as surrogates Binrui Cao University of Oklahoma Norman
5-R01-EB024186-04 Circulating Red Blood Cell Based Nanosensors for Continuous, Real-Time Drug Monitoring Heather Clark Northeastern University
5-R01-EB026291-04 Develop CTC capture technology for both mesenchymal and non-mesenchymal tumors Shulin Li University of Tx Md Anderson Can Ctr
5-R21-EB028583-03 Parallel Selective Capture of Single Circulating Melanoma Cells and Integrated On-Chip Determination of Mutational Status Robbyn Anand Iowa State University
5-R21-EB025393-03 Multiplex single-cell analysis of intracellular protein signaling dynamics Min Xue University of California Riverside