Synthetic Biology and Biomimetic Systems
This division supports projects developing and demonstrating new approaches to control/program biology for biomedical intervention, without preference for any particular disease or application.
Emphasis in this program is on engineering biological and biomimetic systems to sense and actuate in response to human biology for biomedical intervention. Projects should be directed toward overcoming a technological challenge that limits biomedical adoption. This program encourages projects that use a design-build-test approach.
Examples of synthetic biological and biomimetic systems include but are not limited to:
- synthetic genetic circuits for cellular control and decision-making
- bacteria to regulate the microbiome
- T-cells to target and eliminate infectious disease
- platelets to deliver therapeutic agents
- organoid-based devices to replace tissue function
- microphysiological niches to control tissue behavior
Additional emphasis in this program is on the development of screening and processing tools and the discovery of design principles to design, build, and test engineered synthetic biological and biomimetic systems.
|Grant Number||Project Title||Principal Investigator||Institution|
|1-R21-EB026617-01A1||Model Driven Construction of Dual-switch Selection Gene Drives to Combat Drug Resistance||Justin Pritchard||Pennsylvania State University-Univ Park|
|1-R01-EB028320-01||Programmable Synthetic Organelles Built from Disordered Proteins for Cellular Engineering||Matthew Good||University of Pennsylvania|
|1-R01-EB028532-01||Integration of systems and synthetic biology to advance development of human tissues ex vivo||Mo Ebrahimkhani||University of Pittsburgh at Pittsburgh|
|1-R56-EB027729-01A1||Engineering a smart CAR platform for human regulatory T cells||Wilson Wong||Boston University (Charles River Campus)|
Harvard's Base Editor uses modified CRISPR technology to selectively modify single base pair in DNA.